A flexible electrode array for determining regions of motor function activated by epidural spinal cord stimulation in rats with spinal cord injury

作     者：Guang-Wei Mao Jian-Jun Zhang Hao Su Zhi-Jun Zhou Lin-Sen Zhu Xiao-Ying Lü Zhi-Gong Wang Guang-Wei Mao;Jian-Jun Zhang;Hao Su;Zhi-Jun Zhou;Lin-Sen Zhu;Xiao-Ying Lü;Zhi-Gong Wang

作者机构：State Key Laboratory of BioelectronicsSoutheast UniversityNanjingJiangsu ProvinceChina Institute of RF-&OE-ICsSoutheast UniversityNanjingJiangsu ProvinceChina Co-innovation Center of NeuroregenerationNantong UniversityNantongJiangsu ProvinceChina 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2022年第17卷第3期

页      面：601-607页

核心收录：

学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 1010[医学-医学技术（可授医学、理学学位）] 100104[医学-病理学与病理生理学] 100215[医学-康复医学与理疗学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China Nos.61534003 (to ZGW) and 61874024 (to ZGW) 

主　　题：electrode array epidural spinal cord stimulation evoked potentials motor function rehabilitation spinal cord injury spinal segment 

摘      要：Epidural stimulation of the spinal cord is a promising technique for the recovery of motor function after spinal cord *** key challenges within the reconstruction of motor function for paralyzed limbs are the precise control of sites and parameters of *** activate lower-limb muscles precisely by epidural spinal cord stimulation,we proposed a high-density,flexible electrode *** determined the regions of motor function that were activated upon epidural stimulation of the spinal cord in a rat model with complete spinal cord,which was established by a transection *** evaluating the effect of stimulation,the evoked potentials were recorded from bilateral lowerlimb muscles,including the vastus lateralis,semitendinosus,tibialis anterior,and medial *** determine the appropriate stimulation sites and parameters of the lower muscles,the stimulation characteristics were studied within the regions in which motor function was activated upon spinal cord *** the vastus lateralis and medial gastrocnemius,these regions were symmetrically located at the lateral site of L1 and the medial site of L2 vertebrae segment,*** tibialis anterior and semitendinosus only responded to stimulation simultaneously with other *** minimum and maximum stimulation threshold currents of the vastus lateralis were higher than those of the medial *** results demonstrate the ability to identify specific stimulation sites of lower muscles using a high-density and flexible *** also provide a reference for selecting the appropriate conditions for implantable stimulation for animal models of spinal cord *** study was approved by the Animal Research Committee of Southeast University,China(approval No.20190720001) on July 20,2019.