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Impact of pain on health-related quality of life in patients with inflammatory bowel disease

World Journal of Gastroenterology 2010年第25期16卷 3168-3177页

作者： Anja Schirbel Anne Reichert Stephanie Roll Daniel C Baumgart Carsten Büning Bianca Wittig Bertram Wiedenmann Axel Dignass Andreas Sturm Division of Gastroenterology and Hepatology Department of Medicine Charité-Campus Virchow Clinic Universittsmedizin Berlin 13353 Berlin Germany Institute for Social Medicine Epidemiology and Health Economics Campus Mitte Charité-Universittsmedizin Berlin 10117 Berlin Germany Division of Gastroenterology Hepatology and Endocrinology Campus Mitte Charité-Universittsmedizin Berlin 10117 Berlin Germany Division of Gastroenterology Infectiology and Rheumatology Department of Medicine Charité-Campus Benjamin Franklin Universittsmedizin Berlin 12203 Berlin Germany Department of Medicine I Markus-Hospital Wilhelm-Epstein-Str. 4. 60431 Frankfurt/Main Germany

AIM: To evaluate intensity, localization and cofactors of pain in Crohn’s disease and ulcerative colitis patients in connection with health-related quality of life (HRQOL) and disease activity. METHODS: We reviewed and analyzed the responses of 334 patients to a specifically designed questionnairebased on the short inflammatory bowel disease questionnaire (SIBDQ) and the German pain questionnaire. Pain intensity, HRQOL, Crohn’s disease activity index (CDAI) and colitis activity index (CAI) were correlated and verified on a visual analog scale (VAS). RESULTS: 87.9% of patients reported pain. Females and males reported comparable pain intensities and HRQOL. Surgery reduced pain in both genders (P = 0.023), whereas HRQOL only improved in females. Interestingly, patients on analgesics reported more pain (P = 0.003) and lower HRQOL (P = 0.039) than patients not on analgesics. A significant correlation was found in UC patients between pain intensity and HRQOL (P = 0.023) and CAI (P = 0.027), and in CD patients between HRQOL and CDAI (P = 0.0001), but not between pain intensity and CDAI (P = 0.35). No correlation was found between patients with low CDAI scores and pain intensity. CONCLUSION: Most IBD patients suffer from pain and have decreased HRQOL. Our study reinforces the need for effective individualized pain therapy in IBD patients.

关键词： disease activity index Health-related quality of life Inflammatory bowel disease Pain

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Vitamin D therapy in pediatric patients with inflammatory bowel disease:a systematic review and meta-analysis

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World Journal of Pediatrics 2023年第1期19卷 48-57页

作者： Mohammad Hassan Sohouli Fatemeh Farahmand Hosein Alimadadi Parisa Rahmani Farzaneh Motamed Elma Izze da Silva Magalhaes Pejman Rohani Pediatric Gastroenterology and Hepatology Research Center Pediatrics Centre of ExcellenceChildren's Medical CenterTehran University of Medical SciencesTehranIran Department of Clinical Nutrition and Dietetics Faculty of Nutrition and Food TechnologyShahid Beheshti University of Medical SciencesTehranIran Postgraduate Programme in Collective Health Federal University of MaranhaoRua Barao de Itapary155CentroSao LuísMABrazil Pediatrics Gastroenterology Department of PediatricsSchool of MedicineChildren's Medical CenterTehran University of Medical SciencesTehranIran

Background There is some evidence for the role of vitamin D deficiency in the pathogenesis of inflammatory bowel disease(IBD)in the pediatric ***,the results are ***,we have conducted a systematic review and meta-analysis to evaluated the effect of vitamin D on pediatric patients with *** We carried out a systematic search in databases from inception until 20 January *** included all relevant articles that evaluate the efficacy and safety of vitamin D on disease activity,inflammatory factors,and vitamin D and calcium levels in pediatric patients with *** effects models were used to combine the *** main outcomes were then analyzed using weight mean difference(WMD)and respective 95%confidence interval(CI).Results Fifteen treatment arms met the eligibility criteria and were *** estimates indicated that intervention with vitamin D has a significantly beneficial effect on 25-hydroxy vitamin D3[25(OH)D3](pooled WMD of 17.662 ng/mL;CI 9.77-25.46;P<0.001),calcium(pooled WMD of 0.17 mg/dL;CI 0.04-0.30;P=0.009),and inflammatory factors including C-reactive protein(CRP)(pooled WMD of-6.57 mg/L;CI-11.47 to-1.67;P=0.009)and erythrocyte sedimentation rate(ESR)(pooled WMD of-7.94 mm/h;CI-12.65 to-3.22;P=0.001)*** addition,this effect was greater for vitamin D levels at doses greater than 2000 IU,and when follow-up duration was more than 12 *** This study showed that vitamin D therapy can have a significant and beneficial effect on 25(OH)D3,calcium,and inflammatory factors in children and adolescents with IBD.

关键词： disease activity index Inflammation Meta-analysis IBD Pediatric Vitamin D

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Inhibitory Effect of Recombinant IL-25 on the Development of Dextran Sulfate Sodium-Induced Experimental Colitis in Mice

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Cellular & Molecular Immunology 2008年第6期5卷 425-431页

作者： S.S. Salum Mchenga Department of Immunology College of Basic Medical Science China Medical University

The role of interleukin 25 （IL-25） in a number of human diseases still has not been extensively studied, here we attempt to evaluate the role of recombinant IL-25 （rIL-25） in the development of dextran sulfate sodium （DSS）- induced experimental colitis. Acute colitis was induced in female C57BL/6 mice by oral administration of 2.5% DSS in drinking water ad libitum. At the same time as the start of DSS exposure, mice were injected intraperitoneally with 0.4 ＋tg of rIL-25 or PBS. Then disease activity index （DAI）, histological changes and survival rate were observed. The levels of IL-17, IL-23, and TGF-β1 in colon tissues were determined by ELISA, and the production of IL-17 by CD4＋/CD8＋ T cells was detected by intracellular flow cytometry. In contrast to the DSS treated mice, DSS ＋ rIL-25 treated mice displayed a lower DAI, limited histological changes and prolonged survival. The levels of IL-23 and TGF-β1 were significantly elevated in the DSS ＋ rIL-25 treated mice compared to the DSS treated mice. There was no significant difference in the production of IL-17 in colon tissues and CD4＋/CD8＋ T cells between the DSS ＋ rIL-25 treated mice and DSS treated mice. Our findings suggest the role of IL-25 in inhibiting development and progression of acute colitis in DSS-induced mouse colitis model. Cellular ＆ Molecular Immunology. 2008;5（6）：425-431.

关键词： IL-25 dextran sulfate sodium disease activity index colitis

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Role of moxibustion in inflammatory responses during treatment of rat ulcerative colitis

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World Journal of Gastroenterology 2014年第32期20卷 11297-11304页

作者： Yang Han Tie-Ming Ma Mao-Lin Lu Lu Ren Xian-De Ma Zeng-Hua Bai Department of Acupuncture and Massage Liaoning University of Traditional Chinese Medicine Center for Photochemical Sciences Department of Chemistry Bowling Green State University Bowling Green OH 43403 United States

AIM: To investigate the efficacy of moxibustion in ulcerative colitis (UC) rats from morphological, immunological and molecular biological perspectives. METHODS: Thirty-two Sprague-Dawley rats were randomly assigned to a blank control group (normal rats, n = 6) and a model replication (MR) group (UC rats, n = 26). A UC model was established by 2,4,6-trinitrobenzenesulfonic acid/dextran sulfate sodium enema. Rats in the MR group were further randomly assigned to a 9-min moxibustion (9M) group (9 moxa-cone, n = 6), 6-min moxibustion (6M) group (6 moxa-cone, n = 6), 3-min moxibustion (3M) group (3 moxa-cone, n = 6), and a waiting list control (WLC) group (no moxibustion treatment, n = 6). Rats in the moxibustion treatment group were treated in 14 sessions over 28 d. disease activity, local tissue morphology, serum level of interleukin (IL)-8 and IL-10, and expression of Toll-like receptor (TLR)9 as well as nuclear factor (NF)-kappa B p65 in colonic tissue were determined by disease activity index (DAI), hematoxylin and eosin staining, electron microscopy, enzyme-linked immunosorbent assay and Western blotting, respectively. RESULTS: DAI was lowest in the 9M group and highest in the WLC group. The differences in DAI between the moxibustion treatment (3M, 6M, 9M) and no treatment groups were significant for all one-to-one comparisons (0.60 +/- 0.54 vs 1.20 +/- 0.44, 0.60 +/- 0.54 vs 1.80 +/- 0.45, 0.60 +/- 0.54 vs 3.0 +/- 0.45, respectively, P < 0.05). Light and electron microscopy showed that the neatness of the glandular arrangement in colonic mucosal epithelia gradually increased in the WLC, 3M, 6M to 9M groups. IL-8 level successively decreased while IL-10 level increased from the WLC to 3M, 6M and 9M groups. The differences among these groups were significant for all comparisons (105.46 +/- 8.75 vs 76.61 +/- 3.58, 105.46 +/- 8.75 vs 69.78 +/- 1.87, 105.46 +/- 8.75 vs 67.41 +/- 1.84, respectively, P < 0.01 for IL-8; and 30.83 +/- 1.29 vs 75.64 +/- 1.90, 30.83 +/- 1.2

关键词： Moxibustion Ulcerative colitis disease activity index Interleukin-8 Interleukin-10 Toll-like receptor 9 Nuclear factor-kappa B p65

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Fecal microbiota in pouchitis and ulcerative colitis

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World Journal of Gastroenterology 2016年第40期22卷 8929-8939页

作者： Kai-Yu Li Jian-Lin Wang Jiang-Peng Wei Sen-Yang Gao Ying-Ying Zhang Li-Tian Wang Gang Liu Department of General Surgery Tianjin Medical University General Hospital Department of General Surgery Tianjin NanKai Hospital

AIM To investigate the changes in microbiota in feces of patients with ulcerative colitis(UC) and pouchitis using genomic *** Fecal samples were obtained from UC patients with or without an ileal pouch-anal anastomosis(IPAA) procedure, as well as healthy controls. The touchdown polymerase chain reaction technique was used to amplify the whole V3 region of the 16 S r RNA gene, which was transcribed from DNA extracted from fecal samples. Denaturing gradient gel electrophoresis was used to separate the amplicons. The band profiles and similarity indices were analyzed digitally. The predominant microbiota in different groups was confirmed by sequencing the 16 S rR NA gene. RESULTS Microbial biodiversity in the healthy controls was significantly higher compared with the UC groups(P disease activity of UC(r =-6.591, P < 0.01),was decreased in pouchitis patients. The numbers of two types of bacteria, Faecalibacterium prausnitzii and Eubacterium rectale, were reduced in UC. Patients with pouchitis had an altered microbiota composition compared with UC patients. The microbiota from pouchitis patients was less diverse than that from severely active UC patients. Sequencing results showed that similar microbiota, such as Clostridium perfringens, were shared in both UC and *** Less diverse fecal microbiota was present in patients with UC and pouchitis. Increased C. perfringens in feces suggest its role in the exacerbation of UC and pouchitis.

关键词： Pouchitis Intestinal flora Ulcerative colitis disease activity index Ileal pouch-anal anastomosis

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Qingchi San(青赤散)treats ulcerative colitis in mice by inhibiting the nuclear factor-kappa B signaling pathway and Nucleotide-binding oligomerization domain,leucine-rich repeat and pyrin domain-containing 3 inflammasome formation

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Journal of Traditional Chinese Medicine 2023年第1期43卷 68-77页

作者： ZHOU Zhenghua JI Jianbin WANG Hongxia YAN Lin KANG Hongchang Department of Gastroenterology First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300381China National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion Tianjin 300381China

OBJECTIVE:To investigate the efficacy of Qingchi San(青赤散,QCS),a preparation of Traditional Chinese Medicine,on ulcerative colitis(UC)in mice by inhibiting the nuclearfactor-kappa B(NF-κB)signaling pathway and nucleotide-binding oligomerization domain,leucine-rich repeat and pyrin domain-containing 3(NLRP3)inflammasome ***:The UC model was established with male C57BL/6J as the animal ***,disease activity index(DAI),colon length and weight were ***,colonic histology was performed by hematoxylin-eosin(HE)***-1β(IL-1β),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),myeloperoxidase(MPO)and superoxide dismutase(SOD)were performed by enzyme-linked immunosorbent *** 2(COX2)and inducible nitric oxide synthase(iNOS)mRNA expression were conducted by real-time quantitative polymerase chain reaction(RT-qPCR).NF-κB,inhibitor of NF-κBα(iκBα),Phosphorylated inhibitor of NF-κBα(p-iκBα),caspase-1,NLRP3 and Apoptosis-associated speck-like protein containing a caspase recruitment domain(ASC)protein expression were conducted by Western ***:Compared with UC model group,Bodyweight was significantly increased in QCS *** the same time,DAI was significantly decreased in QCS *** length and weight and colonic histology were significantly improved in QCS ***,the expression of IL-1β,IL-6,TNF-α,MPO,SOD,COX2,and iN OS were significantly decreased in QCS ***,the expression of NF-κB signaling pathway-related proteins NF-κB,iκBα,p-iκBα,and the expression of NLRP3 inflammasome related proteins caspase-1,NLRP3 and ASC were significantly decreased in QCS ***:Traditional Chinese drug QCS could treat UC by inhibiting the NF-κB signaling pathway and NLRP3 inflammasome formation in mice.

关键词： colitis ulcerative NF-kappa B disease activity index NLR family pyrin domain-containing 3 protein inflammasomes Qingchi San

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