Impact of pain on health-related quality of life in patients with inflammatory bowel disease

作     者：Anja Schirbel Anne Reichert Stephanie Roll Daniel C Baumgart Carsten Büning Bianca Wittig Bertram Wiedenmann Axel Dignass Andreas Sturm 

作者机构：Division of Gastroenterology and Hepatology Department of Medicine Charité-Campus Virchow Clinic Universittsmedizin Berlin 13353 Berlin Germany Institute for Social Medicine Epidemiology and Health Economics Campus Mitte Charité-Universittsmedizin Berlin 10117 Berlin Germany Division of Gastroenterology Hepatology and Endocrinology Campus Mitte Charité-Universittsmedizin Berlin 10117 Berlin Germany Division of Gastroenterology Infectiology and Rheumatology Department of Medicine Charité-Campus Benjamin Franklin Universittsmedizin Berlin 12203 Berlin Germany Department of Medicine I Markus-Hospital Wilhelm-Epstein-Str. 4. 60431 Frankfurt/Main Germany 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2010年第16卷第25期

页      面：3168-3177页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Disease activity index Health-related quality of life Inflammatory bowel disease Pain 

摘      要：AIM: To evaluate intensity, localization and cofactors of pain in Crohn’s disease and ulcerative colitis patients in connection with health-related quality of life (HRQOL) and disease activity. METHODS: We reviewed and analyzed the responses of 334 patients to a specifically designed questionnairebased on the short inflammatory bowel disease questionnaire (SIBDQ) and the German pain questionnaire. Pain intensity, HRQOL, Crohn’s disease activity index (CDAI) and colitis activity index (CAI) were correlated and verified on a visual analog scale (VAS). RESULTS: 87.9% of patients reported pain. Females and males reported comparable pain intensities and HRQOL. Surgery reduced pain in both genders (P = 0.023), whereas HRQOL only improved in females. Interestingly, patients on analgesics reported more pain (P = 0.003) and lower HRQOL (P = 0.039) than patients not on analgesics. A significant correlation was found in UC patients between pain intensity and HRQOL (P = 0.023) and CAI (P = 0.027), and in CD patients between HRQOL and CDAI (P = 0.0001), but not between pain intensity and CDAI (P = 0.35). No correlation was found between patients with low CDAI scores and pain intensity. CONCLUSION: Most IBD patients suffer from pain and have decreased HRQOL. Our study reinforces the need for effective individualized pain therapy in IBD patients.