Vitamin D therapy in pediatric patients with inflammatory bowel disease:a systematic review and meta-analysis

作     者：Mohammad Hassan Sohouli Fatemeh Farahmand Hosein Alimadadi Parisa Rahmani Farzaneh Motamed Elma Izze da Silva Magalhaes Pejman Rohani Mohammad Hassan Sohouli;Fatemeh Farahmand;Hosein Alimadadi;Parisa Rahmani;Farzaneh Motamed;Elma Izze da Silva Magalh?es;Pejman Rohani

作者机构：Pediatric Gastroenterology and Hepatology Research CenterPediatrics Centre of ExcellenceChildren's Medical CenterTehran University of Medical SciencesTehranIran Department of Clinical Nutrition and DieteticsFaculty of Nutrition and Food TechnologyShahid Beheshti University of Medical SciencesTehranIran Postgraduate Programme in Collective HealthFederal University of MaranhaoRua Barao de Itapary155CentroSao LuísMABrazil Pediatrics GastroenterologyDepartment of PediatricsSchool of MedicineChildren's Medical CenterTehran University of Medical SciencesTehranIran 

出 版 物：《World Journal of Pediatrics》 (世界儿科杂志（英文版）)

年 卷 期：2023年第19卷第1期

页      面：48-57页

核心收录：

学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学] 

基　　金：This research was supported by grant No.1401-1-249-57731 from the Tehran University of Medical Sciences 

主　　题：Disease activity index Inflammation Meta-analysis IBD Pediatric Vitamin D 

摘      要：Background There is some evidence for the role of vitamin D deficiency in the pathogenesis of inflammatory bowel disease(IBD)in the pediatric ***,the results are ***,we have conducted a systematic review and meta-analysis to evaluated the effect of vitamin D on pediatric patients with *** We carried out a systematic search in databases from inception until 20 January *** included all relevant articles that evaluate the efficacy and safety of vitamin D on disease activity,inflammatory factors,and vitamin D and calcium levels in pediatric patients with *** effects models were used to combine the *** main outcomes were then analyzed using weight mean difference(WMD)and respective 95%confidence interval(CI).Results Fifteen treatment arms met the eligibility criteria and were *** estimates indicated that intervention with vitamin D has a significantly beneficial effect on 25-hydroxy vitamin D3[25(OH)D3](pooled WMD of 17.662 ng/mL;CI 9.77-25.46;P0.001),calcium(pooled WMD of 0.17 mg/dL;CI 0.04-0.30;P=0.009),and inflammatory factors including C-reactive protein(CRP)(pooled WMD of-6.57 mg/L;CI-11.47 to-1.67;P=0.009)and erythrocyte sedimentation rate(ESR)(pooled WMD of-7.94 mm/h;CI-12.65 to-3.22;P=0.001)*** addition,this effect was greater for vitamin D levels at doses greater than 2000 IU,and when follow-up duration was more than 12 *** This study showed that vitamin D therapy can have a significant and beneficial effect on 25(OH)D3,calcium,and inflammatory factors in children and adolescents with IBD.