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Knockout of cryptochrome 1 disturbs the locomotor circadian rhythm and development of Plutella xylostella

Insect Science 2023年第4期30卷 1035-1045页

作者： Shao-Ping Chen Dan-Feng Wang Wei-Feng Ma Xiao-Lu Lin Guang Yang State Key Laboratory of Ecological Pest ControlforFujan and Taiwan Crops Institute of Applied EcologyFujian Agriculture and Forestry UniversityFuzhouChina Joint International Research Laboratory of Ecological Pest Control Ministry of EducationFuzhouChina Ministerial and Provincial Joint Innovation Center for Safety Production of Cross-Strait Crops Fujian Agriculture and Forestry UniversityFuzhouChina Key Laboratory of Integrated Pest Management for Fujian-Taiwan Crops Ministry of AgricultureFuzhouChina Key Laboratory of Green Pest Control(Fujian Agriculture and Forestry University) Fujian Province UniversityFuzhouChina

cryptochrome 1(CRY1)functions as a light-responsive photoreceptor,which is crucial for circadian *** identity and function of CRY1 in Plutella xylostella remain *** this study,cryl was cloned and identified in P ***,a cry1-knockout strain(Cry1-KO)of P xylostella with a 2-bp deletion was established from the strain Geneva 88(G88)using the CRISPR/Cas9 *** daily temporal os-cillation of cryl was observed in G88 and Cry1-KO,and cryl mean daily transcription of Cry1-KO was lower than that of *** G88 and Cry1-KO demonstrated rhythmic locomotion under the light/dark condition with Cryl-KO being more active than G88 in the daytime,whereas Cry1-KO completely lost rhythmicity under constant *** developmental period of pre-adult of Cry1-KO was longer than that of G88;the lifespan of the Cry1-KO male adult was shorter than that of G88;the fecundity of Cry1-KO was lower than that of G88;and Cry1-KO showed lower intrinsic rate of increase(r),net repro-duction rate(Ro),finite increase rate(a),and longer mean generation time(T)than *** results indicate that cryl is involved in the regulation of locomotor circadian rhythm and development in P xylostella,providing a potential target gene for controlling the pest and a basis for further investigation on circadian rhythms in lepidopterans.

关键词： circadian rhythm cryptochrome 1 lifespan locomotor activity Plutella xylostella reproduction

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The blue light receptor CRY1 interacts with GID1 and DELLA proteins to repress GA signaling during photomorphogenesis in Arabidopsis

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Molecular Plant 2021年第8期14卷 1328-1342页

作者： Ming Zhong Bingjie Zeng Dongying Tang Jiaxin Yang Lina Qu Jindong Yan Xiaochuan Wang Xin Li Xuanming Liu Xiaoying Zhao College of Biology Hunan Province Key Laboratory of Plant Functional Genomics and Developmental RegulationHunan Hybrid Rape Engineering and Technology Research CenterHunan UniversityChangsha 410082China Shenzhen Institute Hunan UniversityShenzhen 518057China

Light is a critical environmental cue that regulates a variety of diverse plant developmental *** 1(CRY1)is the major photoreceptor that mediates blue light-dependent photomorphogenic responses such as the inhibition of hypocotyl ***(GA)participates in the repression of photomorphogenesis and promotes hypocotyl ***,the antagonistic interaction between blue light and GA is not well ***,we report that blue light represses GA-induced degradation of the DELLA proteins(DELLAs),which are key negative regulators in the GA signaling pathway,via CRY1,thereby inhibiting the GA response during hypocotyl *** in vitro and in vivo biochemical analyses demonstrated that CRY1 physically interacts with GA receptors-GA-INSENSITIVE DWARF 1 proteins(GID1s)-and DELLAs in a blue light-dependent ***,we showed that CRY1 inhibits the association between GID1s and ***,CRY1 antagonizes the function of GID1s to repress the expression of cell elongation-related genes and thus hypocotyl *** together,our findings demonstrate that CRY1 coordinates blue light and GA signali ng for plant photomorphogenesis by stabilizing DELLAs through the binding and in activation of GID1s,providing new in sights into the mechanism by which blue light antagonizes the function of GA in photomorphogenesis.

关键词： cryptochrome 1 blue light gibberellic acid GID1 DELLA proteins

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Therapeutic regulation of autophagy in hepatic metabolism

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Acta Pharmaceutica Sinica B 2022年第1期12卷 33-49页

作者： Katherine Byrnes Sophia Blessinger Niani Tiaye Bailey Russell Scaife Gang Liu Bilon Khambu Department of Pathology and Laboratory Medicine Tulane University School of MedicineNew OrleansLA 70112USA

Metabolic homeostasis requires dynamic catabolic and anabolic processes. Autophagy, an intracellular lysosomal degradative pathway, can rewire cellular metabolism linking catabolic to anabolic processes and thus sustain homeostasis. This is especially relevant in the liver, a key metabolic organ thatgoverns body energy metabolism. Autophagy’s role in hepatic energy regulation has just begun to emerge and autophagy seems to have a much broader impact than what has been appreciated in the field. Though classically known for selective or bulk degradation of cellular components or energy-dense macromolecules, emerging evidence indicates autophagy selectively regulates various signaling proteins to directly impact the expression levels of metabolic enzymes or their upstream regulators. Hence, we review three specific mechanisms by which autophagy can regulate metabolism: A) nutrient regeneration, B) quality control of organelles, and C) signaling protein regulation. The plasticity of the autophagic function is unraveling a new therapeutic approach. Thus, we will also discuss the potential translation of promising preclinical data on autophagy modulation into therapeutic strategies that can be used in the clinic to treat common metabolic disorders.

关键词： Autophagy Liver metabolism Signaling proteins Lysosome Nutrient regeneration Quality control Farnesoid X receptor cryptochrome 1

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The blue light receptor CRY1 interacts with GID1 and DELLA proteins to repress gibberellin signaling and plant growth

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Plant Communications 2021年第6期2卷 82-95页

作者： Baiqiang Yan Zongju Yang Guanhua He Yexing Jing Huixue Dong Lan Ju Yunwei Zhang Yingfang Zhu Yun Zhou Jiaqiang Sun National Key Facility for Crop Gene Resources and Genetic Improvement Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China State Key Laboratory of Crop Stress Adaptation and Improvement Key Laboratory of Plant Stress BiologySchool of Life SciencesHenan UniversityKaifeng 475004China

Improvements in plant architecture,such as reduced plant height under high-density planting,are important for agricultural *** and gibberellin(GA)are essential external and internal cues that affect plant *** this study,we characterize the direct interaction of distinct receptors that link light and GA signaling in Arabidopsis(Arabidopsis thaliana)and wheat(Triticum aestivum L.).We show that the light receptor CRY1 represses GA signaling through interaction with all five DELLA proteins and promotion of RGA protein accumulation in *** analysis shows that CRY1-mediated growth repression is achieved by means of the DELLA ***,we find that CRY1 also directly interacts with the GA receptor GID1 to competitively inhibit the GID1-GAI *** also show that overexpression of TaCRY1a reduces plant height and coleoptile growth in wheat and that TaCRY1a interacts with both TaGID1 and Rht1 to competitively attenuate the TaGID1-Rht1 *** on these findings,we propose that the photoreceptor CRY1 competitively inhibits the GID1-DELLA interaction,thereby stabilizing DELLA proteins and enhancing their repression of plant growth.

关键词： wheat plant height gibberellin cryptochrome 1 GID1 DELLA

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