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clinical value-oriented research paradigm about inheritance and innovation development of TCM dominant diseases

Chinese Herbal Medicines 2023年第4期15卷 476-484页

作者： Dongna Li Hong Guo Lin Niu Qingsheng Yin Yanjun Zhang Pengwei Zhuang State Key Laboratory of Component-based Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Haihe Laboratory of Modern Chinese Medicine Tianjin 301617China First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Tianjin 300193China National clinical Research Center for Chinese Medicine Acupuncture and Moxibustion Tianjin 300193China

Modern medicine has made remarkable achievements in safeguarding people’s life and health,however,it is increasingly found that in the face of complex diseases,selective targeting of single target is often difficult to produce a comprehensive rehabilitation effect,and is prone to induce drug resistance,toxic side *** Chinese medicine(TCM)has a long history of clinical application,and its clinical value in the treatment of complex diseases such as cardiovascular and cerebrovascular diseases,digestive diseases,skin diseases,rheumatism and immunity diseases,and adjuvant treatment of tumors has been proven to have obvious ***,its modern research is relatively lagging behind,and in the face of the aging society and the characteristics of the modern disease spectrum,the traditional knowledge-driven research paradigm seems to be stuck in a bottleneck and difficult to make greater *** on the key issues of TCM development in the new era,the clinical value-oriented strategy becomes to be a new research paradigm of TCM inheritance and innovation development,and dominant diseases would be the focus of the TCM inheritance and innovation development,which has been highly valued in recent years by the TCM academia and the relevant national management *** on the clinical value,a series of policies are formulated for the selection and evaluation of the TCM dominant diseases(TCMDD),and exploratory researches about the clinical efficacy characteristics,the modern scientific connotation interpretation were carried *** clinical value-oriented research paradigm of TCMDD inheritance and innovation development has been initially formed,which is characterized by strong policy support as the guarantee,systematic and standardized selection and evaluation methods as the driving force,scientific and effective research on internal mechanisms as the expansion,and effective clinical guidelines and principles as the transformation,

关键词： clinical value inheritanceand innovation researchparadigm traditional Chinese medicine dominant diseases

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A pan-cancer analysis of the biological function and clinical value of BTLA in tumors

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BIOCELL 2023年第2期47卷 351-366页

作者： XIANGLAI JIANG JIN HE YONGFENG WANG JIAHUI LIU XIANGYANG LI XIANGUI HE HUI CAI Graduate School Ningxia Medical UniversityYinchuan750004China General Surgery clinical Medical Center Gansu Provincial HospitalLanzhou730000China Key Laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology in Gansu Province Gansu Provincial HospitalLanzhou730000China NHC Key Laboratory of Diagnosis and Therapy of Gastrointestinal Tumor Gansu Provincial HospitalLanzhou730000China The First clinical Medical College of Lanzhou University Lanzhou730000China

B and T-lymphocyte attenuator(BTLA)plays an immunosuppressive role by inhibiting T-and B-cell *** is associated with a variety of diseases,especially cancer ***,the function of BTLA in various cancers and its clinical prognostic value have still not been comprehensively *** study aimed to identify the relationship between BTLA and cancer from the perspectives of differences in BTLA expression,its clinical value,immune infiltration,and the correlation with immune-related genes in various *** regarding mRNA expression,miRNA expression,lncRNA expression,and clinical data of patients of 33 existing cancers were collected from the TCGA *** miRNA of BTLA and the lncRNA that interacts with the target miRNA were obtained from the StarBase *** on bioinformatics analysis methods,the relationship between various types of cancers and BTLA was thoroughly investigated,and a competing endogenous RNA network of BTLA,target miRNA,and interacting lncRNA was *** Kaplan-Meier(KM)prognostic analysis of BTLA and target miRNA(has-miR-137)in various types of cancers was completed using the KM *** expression varied in different cancers,with statistical significance in nine cancer *** plotter to analyze the overall survival(OS)and regression-free survival prognosis of cancer patients revealed that the BTLA expression was statistically different in the OS of 11 types of cancers out of 21 types of cancers;the OS of 8 type of cancers was also statistically *** analysis of tumor immune genes revealed a positive correlation of BTLA expression with immunosuppressive gene(CTLA4 and PDCD1)*** Set Enrichment Analysis showed that BTLA and its co-expressed genes mainly act through biological processes and pathways,including immune response regulation,cell surface receptor signaling pathway,antigen binding,antigen receptor-mediated signaling pathway,and leukocyte *** has t

关键词： Pan-cancer BTLA Tumor immunity clinical value

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clinical value of Musculoskeletal Ultrasound in Rehabilitation After Flexor Tendon Rupture Repair of the Hand

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Proceedings of Anticancer Research 2022年第1期6卷 38-42页

作者： Rui Wang Yancheng Third People’s Hospital Yancheng 224000Jiangsu ProvinceChina

Objective:To explore the application effect and clinical value of musculoskeletal ultrasound in the rehabilitation of hand function after flexor tendon rupture ***:In this study,72 patients were selected from among patients who underwent flexor tendon rupture repair of the hand in Yancheng Third People’s Hospital from May 2018 to May 2020;the patients were randomly divided into the control group(routine hand rehabilitation training)and the experimental group(musculoskeletal ultrasound and targeted hand rehabilitation training based on examination results)by die roll,with 34 cases in each group;the hand rehabilitation of the two groups were ***:The excellent and good rate of the total active motion(TAM)of the experimental group(94.44%)was significantly higher than that of the control group(69.44%)(P0.05);after treatment,the degree of stenosis and the diameter of the artery of the experimental group were significantly better than those of the control group(Pclinical rehabilitation.

关键词： Musculoskeletal ultrasound Hand Flexor tendon rupture Repair Hand rehabilitation clinical value

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clinical value of Predictive Nursing Intervention on Deep Venous Thrombosis of Lower Extremities after Cesarean Section

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Medicinal Plant 2024年第4期15卷 73-76页

作者： Xiaole LI Pingquan Hospital Pingquan 067500China

[Objectives]To explore the clinical nursing value of predictive nursing intervention in patients with deep venous thrombosis of lower extremities after cesarean section.[Methods]From December 2022 to April 2023,105 pregnant and lying-in women who were hospitalized in the Gynecology Department of Pingquan Hospital and underwent cesarean section and met the inclusion criteria were included as the study *** to the medical records,they were divided into observation group(n=52 cases)and control group(n=53 cases).The clinical experimental subjects were divided into two *** group was the control group with routine nursing,and the other group was the observation group with predictive nursing *** number of cases of deep venous thrombosis of lower extremities in the two groups was recorded to evaluate the clinical value.[Results]The incidence of deep venous thrombosis of lower extremities in the two groups after cesarean section was compared,and it was suggested that the incidence of the observation group was lower than that of the control group(Pclinical efficacy,which is worthy of recommendation.

关键词： Predictive nursing intervention Cesarean section Deep venous thrombosis of lower extremities clinical value

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clinical value of Endodontic Patients Treated with Calcium Hydroxide Preparations

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Journal of clinical and Nursing Research 2024年第4期8卷 370-374页

作者： Rongfa He Shawan People’s Hospital Panyu DistrictGuangzhou 511483Guangdong ProvinceChina

Objective: To investigate the clinical value of endodontics patients treated with calcium hydroxide preparation. Methods: The study cases were selected from the endodontics patients who visited our hospital during the period from January 2022 to December 2023, and 97 cases were randomly selected according to the numerical table method and divided into two groups. There were 49 cases in the control group and 48 cases in the experimental group. The control group received conventional therapy, while the experimental group received treatment with calcium hydroxide preparation, and the clinical value of the two different treatment modalities was observed and analyzed. Results: In the experimental group, 45 out of 48 patients (93.75%) showed effectiveness, compared to 39 out of 49 patients (79.59%) in the control group. The effectiveness rate was significantly higher in the experimental group (P 0.05), but after 1 and 3 months of treatment, the scores decreased in both groups. However, the experimental group had a greater decrease, indicating lower pain levels (P < 0.05). The experimental group had fewer complications (8.33%) compared to the control group (24.49%), with a significant difference (P < 0.05). Satisfaction with treatment was higher in the experimental group (95.83%) compared to the control group (95.83%), resulting in an overall higher satisfaction rate in the experimental group (83.67%;P < 0.05). Conclusion: The treatment effect of endodontics with calcium hydroxide preparation is remarkable, which not only can effectively help patients to relieve their pain and reduce the incidence of complications but also plays an important role in improving patients’ satisfaction with treatment, which is worthwhile to be vigorously promoted in the clinic and learn from it.

关键词： Endodontics Calcium hydroxide preparations clinical value

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clinical value of assessing serum levels of inflammatory cytokines in the early diagnosis of patients with primary liver carcinoma:a retrospective observational study

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Journal of Bio-X Research 2021年第1期4卷 29-35页

作者： Chengwen He Qin Wei Jun Zhu Qin Qin Huaizhou Wang Shanrong Liu Department of Laboratory Diagnostic Changhai HospitalNaval Military Medical UniversityShanghaiChina

Objective:To identify potential early diagnostic markers for hepatitis B progression to primary liver carcinoma using routine immunological tests based on 6 cytokine ***:Eight hundred and ninety-nine patients with hepatitis B progressing to early primary liver carcinoma admitted to and treated at Changhai Hospital,Naval Military Medical University,Shanghai,China between March 2015 and June 2017 were included in this observational study,including 666 patients with HBsAg^(+),HBeAb^(+),HBcAb^(+)liver carcinoma and 233 patients with HBsAg+,HBeAg+,HBcAb+liver *** operating characteristic(ROC)curves were used to evaluate the efficiency of the different cytokine in the diagnosis of hepatocellular carcinoma in patients with hepatitis *** study was approved by the Institutional Review Board of Changhai Hospital,Naval Military Medical University,China(approval ***2020-080)on June 6,***:Changed levels of interleukin(IL)-1β,IL-2R,IL-8,and tumor necrosis factor(TNF)-a were statistically significant(Pvalue,negative predictive value,and Youden index for the diagnosis of primary liver carcinoma using the combination of IL-1β,IL-2R,IL-8,and TNF-α were 0.938,79.2%,96.7%,96%,82.0%,0.759,*** serum alpha-fetoprotein level in patients with primary liver carcinoma was positively correlated with IL-2R(r=0.3502,P<0.001),IL-8(r=0.1558,P=0.0273),and TNF-α(r=0.2544,P<0.001)*** equation fitted to the results was logit(P)=0.086+0.01IL-2R–0.001IL-8–0.033TNF-α–0.041IL-1β.Conclusion:Our study establishes a novel,potentially valuable diagnostic model based on four cytokines related to the early stages of liver carcinoma.

关键词： clinical value cytokine diagnostic model early diagnosis hepatitis B primary liver carcinoma

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clinical value of Hepatitis B Virus RNA Detection in Patients with Chronic Hepatitis B Infection

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Proceedings of Anticancer Research 2023年第4期7卷 29-32页

作者： Yu Li Yifei Lyu Feng-Yu Xi Department of Infectious Diseases Shaanxi Provincial People’s HospitalXi’an 710068Shaanxi ProvinceChina Department of Gastroenterology Shaanxi Provincial People’s HospitalXi’an 710068Shaanxi ProvinceChina Department of clinical Laboratory Shaanxi Provincial People’s HospitalXi’an 710068Shaanxi ProvinceChina

Objective:To study the clinical value of hepatitis B virus pregenomic RNA(HBV-pgRNA)detection in the treatment of hepatitis ***:60 patients with hepatitis B were included in the *** HBV-pgRNA and HBV DNA levels in different phases of infection and during treatment were detected,and serum hepatitis B surface antigen(HbsAg)titer was detected by chemiluminescent *** was extracted from liver biopsy tissue,and covalently closed circular DNA was detected to predict the therapeutic value in ***:At the initial stage of treatment,the level of HBV-pgRNA in phase I,II,III,and IV showed a gradual *** the levels of HBV-pgRNA before and after treatment,we found that the level of HBV-pgRNA was significantly lower after treatment(Pclinical value of HBV-pgRNA detection in the treatment of hepatitis B is high.

关键词： Hepatitis B virus pregenomic RNA HBV-pgRNA Detection Hepatitis B Treatment clinical value

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Changes and clinical value of Serum Cortisol Levels in Patients with Hypertensive Disorder in Pregnancy

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Journal of clinical and Nursing Research 2020年第3期4卷 74-77页

作者： Gaoxiang Huo Yeqiang Qin Xiucui Bao Xiaoling Yao Zhangwei Pu Jia Sun Yihe Obstetrics and Gynecology Hospital Cangzhou People's HospitalCangzhou 061000Hebei ProvinceChina

Objective:To investigate the changes and the corresponding clinical value of serum cortisol levels in patients with hypertensive disorders during ***:In this study,90 patients with different degrees of hypertensive disorders during pregnancy who were admitted from August 2018 to August 2019 in our hospital were set as the research objects.90 cases were grouped according to the diagnostic criteria in Obstetrics and Gynecology,including 30 cases in each of the hypertension group,the preeclampsia group,and the eclampsia *** 30 healthy pregnant women were selected as the control *** serum cortisol levels of pregnant women in the above four groups were ***:Compared with the control group,the serum cortisol levels in the other three groups were significantly *** perinatal outcome,compared with the control group,the three groups of patients had an increase in Apgar score,preterm birth,stillbirth rate,growth restriction rate and neonatal asphyxia *** were significant differences between groups(P<0.05),and showed as gestational hypertension

关键词： Hypertensive disorders in pregnancy Serum cortisol levels clinical value

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The clinical value of Implementing Early Rehabilitation in the Nursing of Patients with Cerebral Infarction

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Journal of clinical and Nursing Research 2021年第4期5卷 234-237页

作者： Weihua Xu Hubei No.3 People's Hospital of Jianghan University Wuhan CityHubei ProvinceChina

Objective:This research studied the clinical value of implementing early rehabilitation in the nursing of patients with cerebral ***:Eighty-four patients with cerebral infarction in Hubei Third People's Hospital from January 2019 to January 2021 were selected and divided into a control group and a study group using the digital table method in which routine care and early rehabilitation care were given respectively and the effects were ***:Prior to the nursing intervention,there was no significant difference in the National Institutes of Health Stroke Scale(NIHSS)and Barthel index between the two groups of patients,P>*** the nursing intervention,the NIHSS of the study group was lower than that of the control group whereas the Barthel index,Quality of Life Scale,and patient satisfaction in the study group were higher than the control group,P<***:The implementation of early rehabilitation in the nursing of patients with cerebral infarction can effectively improve their neurological function and quality of life in addition to a higher satisfaction among them.

关键词： Cerebral infarction Early rehabilitation care clinical value

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Biological roles and potential clinical values of circular RNAs in gastrointestinal malignancies

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Cancer Biology & Medicine 2021年第2期18卷 437-457页

作者： Xueping Tao Yongfu Shao Jianing Yan Liyang Yang Qihua Ye Qingling Wang Rongdan Lu Junming Guo Department of Biochemistry and Molecular Biology and Zhejiang Key Laboratory of Pathophysiology Ningbo University School of MedicineNingbo 315211China Department of Gastroenterology the Affiliated Hospital of Medical School of Ningbo UniversityNingbo 315020China

Circular RNAs(circ RNAs),a class of endogenous RNA molecules,are produced by alternative splicing of precursor RNA and are covalently linked at the 5′and 3′*** studies have revealed that dysregulated circ RNAs are closely related to the occurrence and progression of gastrointestinal *** evidence indicates that circ RNAs,including circ PVT1,circ LARP4,circ-SFMBT2,cir-ITCH,circ RNA_100782,circ_100395,circ-DONSON,hsa_circ_0001368,circ NRIP1,circ FAT1(e2),circ CCDC66,circ SMARCA5,circ-ZNF652,and circ_0030235 play important roles in the proliferation,differentiation,invasion,and metastasis of cancer cells through a variety of mechanisms,such as acting as micro RNA sponges,interacting with RNA-binding proteins,regulating gene transcription and alternative splicing,and being translated into *** the characteristics of high abundance,high stability,extensive functions,and certain tissue-,time-and diseasespecific expressions,circ RNAs are expected to provide novel perspectives for the diagnoses and treatments of gastrointestinal malignancies.

关键词： Circular RNA gastrointestinal malignancies biological function clinical value digestive system

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