Biological roles and potential clinical values of circular RNAs in gastrointestinal malignancies

作     者：Xueping Tao Yongfu Shao Jianing Yan Liyang Yang Qihua Ye Qingling Wang Rongdan Lu Junming Guo Xueping Tao;Yongfu Shao;Jianing Yan;Liyang Yang;Qihua Ye;Qingling Wang;Rongdan Lu;Junming Guo

作者机构：Department of Biochemistry and Molecular Biology and Zhejiang Key Laboratory of PathophysiologyNingbo University School of MedicineNingbo 315211China Department of Gastroenterologythe Affiliated Hospital of Medical School of Ningbo UniversityNingbo 315020China 

出 版 物：《Cancer Biology & Medicine》 (癌症生物学与医学（英文版）)

年 卷 期：2021年第18卷第2期

页      面：437-457页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(Grant Nos.81702367 and 81772279) the Medical and Health Research Project of Zhejiang Province(Grant No.2018KY159) the Affiliated Hospital of Medical School of Ningbo University Youth Talent Cultivation Program(Grant No.FYQMKY202001) the Scientific Innovation Team Project of Ningbo(Grant No.2017C110019) 

主　　题：Circular RNA gastrointestinal malignancies biological function clinical value digestive system 

摘      要：Circular RNAs(circ RNAs),a class of endogenous RNA molecules,are produced by alternative splicing of precursor RNA and are covalently linked at the 5′and 3′*** studies have revealed that dysregulated circ RNAs are closely related to the occurrence and progression of gastrointestinal *** evidence indicates that circ RNAs,including circ PVT1,circ LARP4,circ-SFMBT2,cir-ITCH,circ RNA_100782,circ_100395,circ-DONSON,hsa_circ_0001368,circ NRIP1,circ FAT1(e2),circ CCDC66,circ SMARCA5,circ-ZNF652,and circ_0030235 play important roles in the proliferation,differentiation,invasion,and metastasis of cancer cells through a variety of mechanisms,such as acting as micro RNA sponges,interacting with RNA-binding proteins,regulating gene transcription and alternative splicing,and being translated into *** the characteristics of high abundance,high stability,extensive functions,and certain tissue-,time-and diseasespecific expressions,circ RNAs are expected to provide novel perspectives for the diagnoses and treatments of gastrointestinal malignancies.