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Patterns of treatment with PDE5 inhibitors in the clinical practice in Italy： longitudinal data from the Erectile Dysfunction Observational Study

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Asian Journal of Andrology 2009年第5期11卷 629-637,I0005页

作者： Ferdinando Fusco[意大利] Riccardo Sicuteri[意大利] Andrea Rossi[意大利] Stathis Kontodimas[意大利] Jose Maria Haro[意大利] Ciro Imbimbo[意大利] 无

The Erectile Dysfunction Observational Study （EDOS） is a 6-months observational prospective multicentric study enrolling men with erectile dysfunction （ED） who asked, to be started on a treatment or to change a previous treatment. Aims of the study were to analyse the pattern of treatment and compare the efficacy of treatments used. Patients were enrolled during a normal hospital visit and were prescribed a treatment for ED. They were asked at baseline and after 3 and 6 months, to answer a set of questions from the International Index of Erectile Function, Erectile Dysfunction Inventory of Treatment Satisfaction （EDITS） and Short Form of the Psychological and Interpersonal Relationships Scale questionnaires （SF-PAIRS）. Clinicians were free to prescribe any therapy for ED available in the market, and to change therapy at any time during the study. Out of 1 338 patients, available for analysis at 6 months, 624 （47%） changed their treatment during the study and 714 （53%） continued with the drug prescribed at baseline. Patients assuming tadalafil had a significantly higher probability of maintaining the same treatment compared to sildenafil or vardenafil. There was no clinically significant difference in terms of efficacy, patient satisfaction, self-confidence and spontaneity between the different inhibitors of PDE5. The ‘time concerns＇ domain score of SF-PAIRS, was statistically better in patients assuming tadalafil. In conclusion sildenafil, vardenafil and tadalafil show similar efficacy in the clinical practice. However, patients receiving tadalafil display a lower risk to discontinue or change the treatment.

关键词： clinical practice Italy phosphodiesterase type 5 inhibitors sildenafil tadalafil vardenafil

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Formulation of international standards of Chinese medicine technology:clinical practice guide of Chinese medicine for cough

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Journal of Traditional Chinese Medicine 2024年第2期44卷 396-402页

作者： FANG Hanyu HONG Zheng LI Deming ZHANG Hongchun SHI Yihang LI Xiaojuan SUN Zengtao CHEN Wei ZHANG Chuchu ZU Yaqi Beijing University of Chinese medicine Beijing 100029China Department of Traditional Chinese Medicine for Pulmonary Diseases Center of Respiratory MedicineChina-Japan Friendship HospitalBeijing 100029 National Center for Respiratory Medicine Beijing 100029China Department of Traditional Chinese Medicine for Pulmonary Diseases Center of Respiratory MedicineChina-Japan Friendship HospitalBeijing 100029China Tianjin University of Traditional Chinese Medicine Tianjin 301617China Second Teaching Hospital of Tianjin University of Traditional Chinese Medicine Tianjin 300250China Center for Evidence-based Medicine Beijing University of Chinese MedicineBeijing 100029China Institute of Information on Traditional Chinese Medicine China Academy of Chinese Medical SciencesBeijing 100700China

OBJECTIVE:To formulate the first clinical practice guideline for the treatment of cough using Chinese medicine based on the grading of recommendations assessment,development,and evaluation(GRADE)systematic approach,including clinical evidence,evaluation of ancient literature,and expert ***:In the process of development,the regulation of"evidence-based,consensus-assisted,and empirical"was followed,and a comprehensive systematic approach of recommendation assessment,GRADE,evidence-based evaluation,expert consensus,and the Delphi method was *** the process of guideline development,evidence-based evaluation of ancient literature was included for the first time,and clinical evidence was fully integrated with clinical expert ***:The clinical practice guidelines for the treatment of cough with Chinese herbal medicine were developed after a comprehensive consideration of evidence-based evaluation and expert *** guideline recommendations focused on recommending herbal compound decoctions and Chinese patent medicines for cough in different *** on the GRADE systematic approach,we conducted an evidence-based evaluation of the recommended Chinese patent medicines one by one;meanwhile,the expert consensus method was used to unify the recommendations of ***:Based on clinical evidence,ancient literature evaluation,and expert consensus,a clinical practice guideline for Traditional Chinese Medicine(TCM)in the treatment of cough was developed,providing the first current clinical practice guideline for domestic and foreign TCM and Western medicine practitioners,especially respiratory professionals at home and abroad.

关键词： Medicine Chinese Traditional clinical practice cough practice guide international standard

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Treatment of chronic hepatitis B in clinical practice with entecavir or tenofovir

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World Journal of Gastroenterology 2014年第23期20卷 7169-7180页

作者： Ezequiel Ridruejo Hepatology Section Departament of MedicineCentro de Educación Médica e Investigaciones Clínicas Norberto Quirno "CEMIC"Ciudad Autónoma de Buenos AiresC1425ASG Buenos AiresArgentina

Results from phase III clinical trials clearly demonstrate the efficacy and safety of entecavir and tenofovir in the controlled environment of randomized clinical studies. There are several studies with both drugs performed in clinical practice (also called “real life studies”). Despite the pros and cons, studies performed in real life conditions represent everyday practice and add important information about long term treatment effectiveness and safety in this clinical setting. This review shows that patients treated with first line nucleos(t)ide analogs at referral centres, with good clinical follow-up and adherence to international guidelines, can achieve high treatment response rates with a very low rate of adverse events.

关键词： Hepatitis B clinical practice Entecavir Tenofovir Real life

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Inter-relationships between gastric emptying and glycaemia:Implications for clinical practice

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World Journal of Diabetes 2023年第5期14卷 447-459页

作者： Tejaswini Arunachala Murthy Marianne Chapman Karen L Jones Michael Horowitz Chinmay S Marathe Adelaide Medical School University of AdelaideAdelaide 5000SAAustralia Intensive Care Unit Royal Adelaide HospitalAdelaide 5000SAAustralia NHMRC Centre of clinical Research Excellence in Nutritional Physiology Interventions and OutcomesUniversity of AdelaideAdelaide 5000SAAustralia Endocrine and Metabolic Unit Royal Adelaide HospitalAdelaide 5000SAAustralia

Gastric emptying(GE)exhibits a wide inter-individual variation and is a major determinant of postprandial glycaemia in health and diabetes;the rise in blood glucose following oral carbohydrate is greater when GE is relatively more rapid and more sustained when glucose tolerance is ***,GE is influenced by the acute glycaemic environment acute hyperglycaemia slows,while acute hypoglycaemia accelerates *** GE(gastroparesis)occurs frequently in diabetes and critical *** diabetes,this poses challenges for management,particularly in hospitalised individuals and/or those using *** critical illness it compromises the delivery of nutrition and increases the risk of regurgitation and aspiration with consequent lung dysfunction and ventilator *** advances in knowledge relating to GE,which is now recognised as a major determinant of the magnitude of the rise in blood glucose after a meal in both health and diabetes and,the impact of acute glycaemic environment on the rate of GE have been made and the use of gut-based therapies such as glucagon-like peptide-1 receptor agonists,which may profoundly impact GE,in the management of type 2 diabetes,has become *** necessitates an increased understanding of the complex inter-relationships of GE with glycaemia,its implications in hospitalised patients and the relevance of dysglycaemia and its management,particularly in critical *** approaches to management of gastroparesis to achieve more personalised diabetes care,relevant to clinical practice,is *** studies focusing on the interactions of medications affecting GE and the glycaemic environment in hospitalised patients,are required.

关键词： Glycaemia Gastric emptying clinical practice Glucagon-like peptide-1

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China Association of Acupuncture–Moxibustion Evidence-based clinical practice guideline of acupuncture and moxibustion: Primary dysmenorrhea

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World Journal of Acupuncture-Moxibustion 2019年第4期29卷 294-300页

作者： Ji-ping Zhao Bi-ling Wen Jun Wang Xiao-dong Wu Ming-jie Zi Peng Wang Peng Bai Sheng-nan Guo Sheng Chen 机构不详

Dysmenorrhea refers to periodic abdominal pain,or radiating to lumbosacral *** the severe case,it is intolerable,combined with nausea and vomiting *** disease is commonly seen in unmarried young *** studies have shown that dysmenorrhea is the most common gynecological disease,especially in young women[1].Acupuncture and moxibustion have a long history in the treatm ent of primary dysmenorrhea(hereinafter referred to as PD),and compared with medication,the advantages are presented in the *** by the Standardization Working Committee of China Association for Acupuncture and Moxibustion(CAAM),Department of Acupuncture and Moxibustion,Dongzhimen Hospital,Beijing University of Traditional Chinese Medicine has undertaken the drafting of Evidence-Based clinical practice Guideline of Acupuncture and Moxibustion:Primary Dysmenorrhea(hereinafter referred to as the Guideline).The Guideline was issued in 2014 by *** summarizes the research achievements in acupuncture-moxibustion treatm ent for dysmenorrhea in recent decades and is intended to standardize the clinical regimen of treatm ent with acupuncture and moxibustion so as to improve the clinical effect.

关键词： Evidence based medicine clinical practice Guideline Acupuncture and moxibustion Primary dysmenorrhea

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Medical care and clinical practice for disabled elderly

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Frontiers of Nursing 2018年第1期5卷 7-16页

作者： Rui-Fang Zhu Shi-Fan Han School of Nursing Shanxi Medical UniversityTaiyuanShanxi 030001China First Hospital of Shanxi Medical University TaiyuanShanxi 030001China

At preasent,with the continuous development of the trend of population aging worldwide,more elderiy people are increasingly facing s-erious life disorders caused by physical and mental *** this study,the common symptoms and the nursing practice related to diseases of the disabled elderly are reviewed with reference to the basic concepts of disability care and the current situation of domestic and foreign research,which is expected to provide the basis for the construction of a new model of disability nursing.

关键词： disability elderly disability care clinical practice symptoms disease

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Chinese herbal medicines for prostate cancer therapy: From experimental research to clinical practice

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Chinese Herbal Medicines 2023年第4期15卷 485-495页

作者： Fanming Kong Chaoran Wang Jing Zhang Xiaoqun Wang Binxu Sun Xian Xiao Haojian Zhang Yanqi Song Yingjie Jia Department of Oncology First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300381China National clinical Research Center for Chinese Medicine Acupuncture and Moxibustion Tianjin 300381China Graduate School Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Traditional Chinese Medicine Tianjin Medical University General HospitalTianjin 300052China

Prostate cancer remains the second most common malignancy in men worldwide, is a global health issue,and poses a huge health burden. Precision medicine provides more treatment options for prostate cancer patients, but its popularity, drug resistance, and adverse reactions still need to be focused on. Chinese herbal medicines(CHMs) have been widely accepted as an alternative therapy for cancer, with the advantages of multiple targets, multiple pathways, and low toxicity. We searched the experimental research and clinical practice of CHMs for prostate cancer treatment published in Pub Med, Embase, and Web of Science in the last five years. We found five CHM formulas and six single CHM extracts as well as 12 CHM-derived compounds, which showed induction of apoptosis, autophagy, and cell cycle arrest, suppression of angiogenesis, proliferation, and migration of prostate cancer cells, reversal of drug resistance,and enhancement of anti-tumor immunity. The mechanisms of action include the PI3K/Akt/mTOR, AR,EGFR and Wnt/β-catenin signaling pathways, which are commonly implicated in the development of prostate cancer. We also summarized the advantages of CHMs in patients with hormone-sensitive and castration-resistant prostate cancer and provided ideas for their further experimental design and application.

关键词： Chinese herbal medicines clinical practice experimental research prostate cancer review

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Demonstration of caring by males in clinical practice:A literature review

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International Journal of Nursing Sciences 2016年第3期3卷 323-327页

作者： Wen Zhang Yi-Lan Liu Department of Obstetrics and Gynecology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina The Union Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina

Gender stereotyping on the role of male nurses in the use of intimate care,especially the application of touch,was *** barriers for men to provide care were *** adopted by male nurses to overcome these barriers were *** review of literature showed that role stereotyping is still prevalent within *** media should recognize the diversity of caring and apply positive materials to shape a new image of *** nursing faculty should develop an atmosphere of acceptance and empower male nursing students in the nursing school and *** nurses themselves should deeply believe that nursing is a profession suitable for both genders.

关键词： Nurse Male Caring clinical practice Touch Review

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How to Connect the Gap between clinical Trials and clinical practice

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Chinese Journal of Integrative Medicine 2008年第4期14卷 309-311页

作者：商洪才徐宏娟陈静张伯礼李幼平 Mike J Clarke West Chin'a Hospital of Sichuan University Academy of TCM in Tianjin University of Traditional Chinese Medicine Evidence-Based Medicine Centre in Tianjin University of TCM Heart Department in Tianjin Chest Hospital West China Hospital of Sichuan University UK Cochrane Centre OxfordOX27LGUK

clinical research methods have been rapidly developing, and the design of clinical trials including traditional Chinese medicine is advancing. To a certain extent, all of these ensure that the results of clinical research are objective and scientific, but whether these results and the resulting guidelines or consensus have much practical significance on clinical practice is still controversial. The authors engage in both clinical practice and clinical research; they strongly feel that it is necessary to discuss the relationship between clinical trials and clinical practice. This essay discusses this relationship in four parts.

关键词： clinical trials clinical practice external validity

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Diagnosis and Management of Biliary Strictures after Deceased-Donor Liver Transplantation Based on clinical practice

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Surgical Science 2024年第3期15卷 99-110页

作者： Jianqiang Chen Chengyou Du Department of Hepatobiliary Surgery The First Affiliated Hospital of Chongqing Medical University Chongqing China

Biliary complications are still the main complications for liver transplantation recipients. Biliary strictures comprise the major part of all biliary complications after deceased-donor liver transplantation (LT). Biliary strictures following LT are divided into anastomotic strictures (AS) and non-anastomotic strictures (NAS). A Limitation of current published researches is that most studies aren’t based on clinical practice. The aim of this review is to summarize risk factors, clinical presentation, diagnosis and management in post-LT biliary strictures.

关键词： Biliary Strictures Liver Transplantation clinical practice Anastomotic Strictures Non-Anastomotic Strictures

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