Inter-relationships between gastric emptying and glycaemia:Implications for clinical practice

作     者：Tejaswini Arunachala Murthy Marianne Chapman Karen L Jones Michael Horowitz Chinmay S Marathe 

作者机构：Adelaide Medical SchoolUniversity of AdelaideAdelaide 5000SAAustralia Intensive Care UnitRoyal Adelaide HospitalAdelaide 5000SAAustralia NHMRC Centre of Clinical Research Excellence in Nutritional PhysiologyInterventions and OutcomesUniversity of AdelaideAdelaide 5000SAAustralia Endocrine and Metabolic UnitRoyal Adelaide HospitalAdelaide 5000SAAustralia 

出 版 物：《World Journal of Diabetes》 (世界糖尿病杂志（英文版）（电子版）)

年 卷 期：2023年第14卷第5期

页      面：447-459页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Glycaemia Gastric emptying Clinical practice Glucagon-like peptide-1 

摘      要：Gastric emptying(GE)exhibits a wide inter-individual variation and is a major determinant of postprandial glycaemia in health and diabetes;the rise in blood glucose following oral carbohydrate is greater when GE is relatively more rapid and more sustained when glucose tolerance is ***,GE is influenced by the acute glycaemic environment acute hyperglycaemia slows,while acute hypoglycaemia accelerates *** GE(gastroparesis)occurs frequently in diabetes and critical *** diabetes,this poses challenges for management,particularly in hospitalised individuals and/or those using *** critical illness it compromises the delivery of nutrition and increases the risk of regurgitation and aspiration with consequent lung dysfunction and ventilator *** advances in knowledge relating to GE,which is now recognised as a major determinant of the magnitude of the rise in blood glucose after a meal in both health and diabetes and,the impact of acute glycaemic environment on the rate of GE have been made and the use of gut-based therapies such as glucagon-like peptide-1 receptor agonists,which may profoundly impact GE,in the management of type 2 diabetes,has become *** necessitates an increased understanding of the complex inter-relationships of GE with glycaemia,its implications in hospitalised patients and the relevance of dysglycaemia and its management,particularly in critical *** approaches to management of gastroparesis to achieve more personalised diabetes care,relevant to clinical practice,is *** studies focusing on the interactions of medications affecting GE and the glycaemic environment in hospitalised patients,are required.