Chinese herbal medicines for prostate cancer therapy: From experimental research to clinical practice

作     者：Fanming Kong Chaoran Wang Jing Zhang Xiaoqun Wang Binxu Sun Xian Xiao Haojian Zhang Yanqi Song Yingjie Jia Fanming Kong;Chaoran Wang;Jing Zhang;Xiaoqun Wang;Binxu Sun;Xian Xiao;Haojian Zhang;Yanqi Song;Yingjie Jia

作者机构：Department of OncologyFirst Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300381China National Clinical Research Center for Chinese Medicine Acupuncture and MoxibustionTianjin 300381China Graduate SchoolTianjin University of Traditional Chinese MedicineTianjin 301617China Department of Traditional Chinese MedicineTianjin Medical University General HospitalTianjin 300052China 

出 版 物：《Chinese Herbal Medicines》 (中草药（英文版）)

年 卷 期：2023年第15卷第4期

页      面：485-495页

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by the National Administration of Traditional Chinese Medicine: 2019 Project of Building Evidencebased Practice Capacity for TCM (No. 2019XZZX-ZL007) National Administration of Traditional Chinese Medicine: Jia Yingjie National Famous Traditional Chinese Medicine Experts Academic Experience Inheritance Project (No. 974022) 

主　　题：Chinese herbal medicines clinical practice experimental research prostate cancer review 

摘      要：Prostate cancer remains the second most common malignancy in men worldwide, is a global health issue,and poses a huge health burden. Precision medicine provides more treatment options for prostate cancer patients, but its popularity, drug resistance, and adverse reactions still need to be focused on. Chinese herbal medicines(CHMs) have been widely accepted as an alternative therapy for cancer, with the advantages of multiple targets, multiple pathways, and low toxicity. We searched the experimental research and clinical practice of CHMs for prostate cancer treatment published in Pub Med, Embase, and Web of Science in the last five years. We found five CHM formulas and six single CHM extracts as well as 12 CHM-derived compounds, which showed induction of apoptosis, autophagy, and cell cycle arrest, suppression of angiogenesis, proliferation, and migration of prostate cancer cells, reversal of drug resistance,and enhancement of anti-tumor immunity. The mechanisms of action include the PI3K/Akt/mTOR, AR,EGFR and Wnt/β-catenin signaling pathways, which are commonly implicated in the development of prostate cancer. We also summarized the advantages of CHMs in patients with hormone-sensitive and castration-resistant prostate cancer and provided ideas for their further experimental design and application.