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Histopathological classification and follow-up analysis of chronic atrophic gastritis

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World Journal of Clinical Cases 2021年第16期9卷 3838-3847页

作者： Yang-Kun Wang Lan Shen Tian Yun Bin-Feng Yang Chao-Ya Zhu Su-Nan Wang Department of Pathology Shenzhen Hospital of Southern Medical UniversityShenzhen 518100Guangdong ProvinceChina Department of Pathology Shenzhen Hospital of Southern Medical UniversityShenzhen 518055Guangdong ProvinceChina Department of Pathology 989^(th)Hospital of PLALuoyang 471000Henan ProvinceChina Department of Pathology Xinxiang Central HospitalXinxiang 453000Henan ProvinceChina Department of Pathology The Third Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Shenzhen Vocational and Technical College Shenzhen 518055Guangdong ProvinceChina

BACKGROUND The pathological diagnosis and follow-up analysis of gastric mucosal biopsy have been paid much attention,and some scholars have proposed the pathological diagnosis of 12 kinds of lesions and accompanying pathological diagnosis,which is of great significance for the treatment of precision gastric diseases,the improvement of the early diagnosis rate of gastric cancer,and the reduction of missed diagnosis rate and misdiagnosis *** To perform a histopathological classification and follow-up analysis of chronic atrophic gastritis(CAG).METHODS A total of 2248 CAG tissue samples were collected,and data of their clinical characteristics were also *** on these samples,the expression levels of Mucin 1(MUC1),MUC2,MUC5AC,and MUC6 in CAG tissue were tested by immunohistochemical ***,we followed these patients for up to four *** difference between different stages of gastroscopic biopsy was *** Through observation,it is believed that CAG should be divided into four types,simple type,hyperplasia type,intestinal metaplasia(IM)type,and intraepithelial neoplasia(IEN)*** CAG accounted for 9.1%(205/2248),which was more common in elderly people over 60 years *** main change was that the lamina propria glands were reduced in size and *** CAG accounted for 29.1%(654/2248),mostly occurring between 40 and 60 years *** main change was that the lamina propria glands were atrophy accompanied by glandular hyperplasia and slight expansion of the *** CAG accounted for 50.4%(1132/2248),most of which increased with age,and were more common in those over 50 *** atrophy of the lamina propria glands was accompanied by significant IM,and the mucus containing sialic acid or sulfate was distinguished according to the nature of the *** IEN type CAG accounted for 11.4%(257/2248),which developed from the previous types,with severe gland atrophy and reduced mucus secretion,and is an important precancer

关键词： Gastric mucosal biopsy chronic atrophic gastritis Histological typing Immunohistochemistry Follow-up review

Effects of Granule Dendrobii on chronic atrophic gastritis induced by N-methyl-N'-nitro-N-nitrosoguanidine in rats

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World Journal of Gastroenterology 2022年第32期28卷 4668-4679页

作者： Yue Wu Yu Li Xiao-Ming Jin Guan-Hai Dai Xuan Chen Ye-Ling Tong Ze-Ming Ren Yu Chen Xiao-MinXue Ren-Zhao Wu First College of Clinical Medicine Zhejiang Chinese Medical UniversityHangzhou 310052Zhejiang ProvinceChina Institute of Basic Medicine Zhejiang Academy of Traditional Chinese MedicineHangzhou 310007Zhejiang ProvinceChina College of Basic Medicine Zhejiang Chinese Medical UniversityHangzhou 310052Zhejiang ProvinceChina Stark Neuroscience Research Institute&Department of Anatomy Cell Biology and PhysiologyIndiana University School of MedicineIndianapolisIN 46202United States Department of Experimental Animals Zhejiang Academy of Traditional Chinese MedicineHangzhou 310007Zhejiang ProvinceChina

BACKGROUND Dendrobium officinale is an herb of Traditional Chinese Medicine(TCM)commonly used for treating stomach *** formula of Granule Dendrobii(GD)consists of Dendrobium officinale and American Ginseng(Radix Panacis quinquefolii),and is a potent TCM product in *** treatment with GD can promote gastric acid secretion and alleviate gastric gland atrophy in chronic atrophic gastritis(CAG)requires *** To determine the effect of GD treatment on CAG and its potential cellular *** A CAG model was induced by feeding rats N-methyl-N'-nitro-N-nitrosoguanidine(MNNG)for 12 *** oral administration of low,moderate,and high doses of GD in CAG rats for 8 wk,its effects on body weight,gastric mucosa histology,mucosal atrophy,intestinal metaplasia,immunohistochemical staining of proliferating cell nuclear antigen(PCNA)and B-cell lymphoma-2,and hemoglobin and red blood cells were *** The body weights of MNNG-induced CAG model rats before treatment(143.5±14.26 g)were significantly lower than that of healthy rats(220.2±31.20 g,P<0.01).At the 8th week of treatment,the body weights of rats in the low-,moderate-,and high-dose groups of GD(220.1±36.62 g)were significantly higher than those in the untreated group(173.3±28.09 g,all P<0.01).The level of inflammation in gastric tissue of the high-dose group(1.68±0.54)was significantly reduced(P<0.01)compared with that of the untreated group(3.00±0.00,P<0.05).The number and thickness of gastric glands in the high-dose group(31.50±6.07/mm,306.4±49.32μm)were significantly higher than those in the untreated group(26.86±6.41/mm,244.3±51.82μm,respectively,P<0.01 and P<0.05),indicating improved atrophy of gastric *** areas of intestinal metaplasia were significantly lower in the high-dose group(1.74%±1.13%),medium-dose group(1.81%±0.66%)and low-dose group(2.36%±1.08%)than in the untreated group(3.91%±0.96%,all P<0.01).The expression of PCNA in high-dose group was significantly

关键词： chronic atrophic gastritis Granule Dendrobii N-methyl-N'-nitro-N-nitrosoguanidine Intestinal metaplasia

Yangyin Huowei mixture alleviates chronic atrophic gastritis by inhibiting the IL-10/JAK1/STAT3 pathway

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2296-2307页

作者： Shan-Shan Xie Yong Zhi Chang-Ming Shao Bin-Fang Zeng Department of Traditional Chinese Medicine Xinjiang Medical UniversityUrumqi 830017Xinjiang Uygur Autonomous RegionChina

BACKGROUND The Chinese medicine Yangyin Huowei mixture(YYHWM)exhibits good clinical efficacy in the treatment of chronic atrophic gastritis(CAG),but the mechanisms underlying its activity remain *** To investigate the therapeutic effects of YYHWM and its underlying mechanisms in a CAG rat *** Sprague-Dawley rats were allocated into control,model,vitacoenzyme,and low,medium,and high-dose YYHWM *** was induced in rats using Nmethyl-N′-nitro-N-nitrosoguanidine,ranitidine hydrochloride,hunger and satiety perturbation,and ethanol *** an 8-wk intervention period,stomach samples were taken,stained,and examined for histopathological *** was utilized to quantify serum levels of PG-I,PG-II,G-17,IL-1β,IL-6,and TNF-α.Western blot analysis was performed to evaluate protein expression of IL-10,JAK1,and *** The model group showed gastric mucosal layer disruption and inflammatory cell *** with the blank control group,serum levels of PGI,PGII,and G-17 in the model group were significantly reduced(82.41±3.53 vs 38.52±1.71,23.06±0.96 vs 11.06±0.70,and 493.09±12.17 vs 225.52±17.44,P<0.01 for all),whereas those of IL-1β,IL-6,and TNF-αwere significantly increased(30.15±3.07 vs 80.98±4.47,69.05±12.72 vs 110.85±6.68,and 209.24±11.62 vs 313.37±36.77,P<0.01 for all),and the protein levels of IL-10,JAK1,and STAT3 were higher in gastric mucosal tissues(0.47±0.10 vs 1.11±0.09,0.49±0.05 vs 0.99±0.07,and 0.24±0.05 vs 1.04±0.14,P<0.01 for all).Compared with the model group,high-dose YYHWM treatment significantly improved the gastric mucosal tissue damage,increased the levels of PGI,PGII,and G-17(38.52±1.71 vs 50.41±3.53,11.06±0.70 vs 15.33±1.24,and 225.52±17.44 vs 329.22±29.11,P<0.01 for all),decreased the levels of IL-1β,IL-6,and TNF-α(80.98±4.47 vs 61.56±4.02,110.85±6.68 vs 89.20±8.48,and 313.37±36.77 vs 267.30±9.31,P<0.01 for all),and evidently decreased the protein levels of IL-10 and STAT3 in gastric mucosal tissues(1

关键词： Yangyin Huowei mixture IL-10/JAK1/STAT3 pathway chronic atrophic gastritis Inflammatory factor Gastric secretory function

Efficacy and safety of Huangqi Jianzhong decoction in the treatment of chronic atrophic gastritis:A meta-analysis

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World Journal of Clinical Cases 2023年第24期11卷 5710-5720页

作者： Xin-Peng Yan Wen Si Ming-Sheng Ding Yuan-Fen Tian Zhuang Guo Department of Traditional Chinese Medicine Shengli Oilfield Central HospitalDongying 257034Shandong ProvinceChina Department of Endocrinology Shengli Oilfield Central HospitalDongying 257034Shandong ProvinceChina Children’s Rehabilitation and Health Care Department Shengli Oilfield Central HospitalDongying 257034Shandong ProvinceChina Department of Gastroenterology Shengli Oilfield Central HospitalDongying 257034Shandong ProvinceChina

BACKGROUND chronic atrophic gastritis is a persistent disorder of the digestive system where the gastric mucosa epithelium and glands undergo atrophy,leading to a decrease in their number and thinning of the gastric *** is worth noting that the prevalence of chronic atrophic gastritis is higher in China compared to the global average,and it is also considered a precancerous condition for gastric *** To evaluate the efficacy of Huangqi Jianzhong decoction in treating chronic atrophic *** atrophic gastritis is a persistent illness characterized by the progressive disappearance of healthy gastric glands due to repeated *** Jianzhong decoctions are widely used in China to treat chronic atrophic ***,there is limited scientific evidence regarding their efficacy in treating this *** The present meta-analysis adhered to the PRISMA guidelines and used the Cochrane Collaboration *** performed a comprehensive search for clinical trials investigating the use of Huangqi Jianzhong decoction in treating chronic atrophic gastritis published until January *** risk of bias and the quality of the included studies were evaluated using the Cochrane Handbook ***,a meta-analysis was conducted using the RevMan 5.4 softRESULTS This study included a total of 13 articles,comprising 1269 *** meta-analysis was conducted on these 13 articles,yielding the following results:I2=0%,P=0.60,[RR=1.24,95%CI:1.18 to 1.30,P<0.00001].The forest plot analysis of the Helicobacter pylori clearance rate revealed I2=0%,P=0.36,[RR=1.20,95%CI:1.05 to 1.38,P=0.009].The forest plot of PG-I level showed I2=99%,P<0.00001,[MD=4.99,95%CI:-1.59 to 11.58,P=0.14].The forest plot of stomach pain demonstrated I2=54%,P=0.04,[MD=-0.63,95%CI:-0.68 to-0.58,P<0.00001].The forest plot of reflux indicated I2=82%,P=0.0009,[MD=-0.48,95%CI:-0.63 to-0.33,P<0.00001].The forest plot of recurrence rate exhibited I2=0%,P=0.92,[RR=0.15,95

关键词： Meta-analysis chronic atrophic gastritis Huangqi Jianzhong decoction Safety

Yiwei Xiaoyu granules for treatment of chronic atrophic gastritis with deficiency syndrome of the spleen and stomach

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World Journal of Clinical Cases 2024年第13期12卷 2201-2209页

作者： Wan-Qun Chen Qing-Feng Fan Yuan-Jun He Fei Li Xin Wu Yan-Ping Li Xiao-Jun Yang Department of Gastroenterology Chongqing Hospital of Traditional Chinese MedicineChongqing 400000China

BACKGROUND The Correa sequence,initiated by Helicobacter pylori(***),commonly progresses to gastric cancer through the stage of chronic atrophic gastritis(CAG).Although eradication of *** only reduces the risk of gastric cancer,it does not eliminate the risk for neoplastic *** Xiaoyu granules(YWXY)are a commonly used composite preparation in Chinese ***,the pursuit of excellence in clinical trials and the establishment of standardized animal experiments are still needed to contribute to full understanding and application of traditional Chinese medicine in the treatment of *** To demonstrate the effectiveness of YWXY in patients with CAG and spleenstomach deficiency syndrome(DSSS),by alleviating histological scores,improving response rates for pathological lesions,and achieving clinical efficacy in relieving DSSS *** We designed a double-blind,randomized,controlled *** study enrolled seventy-two ***-negative patients(mean age,52.3 years;38 men)who were randomly allocated to either the treatment group or control group in a 1:1 ratio,and treated with 15 g YWXY or 0.36 g Weifuchun(WFC)tablet combined with the respective dummy for 24 *** pre-randomization phase resulted in the exclusion of 72 patients:50 participants did not meet the inclusion criteria,12 participants declined to participate,and 10 participants were excluded for various other *** visits were conducted during the study,and histopathological examination with target endoscopic biopsy of narrow-band imaging was requested before the first and seventh *** also evaluated endoscopic performance scores,total symptom scores,serum pepsinogen and *** Six patients did not complete the trial *** with YWXY improved the Operative Link on Gastric Intestinal Metaplasia Assessment(OLGIM)stage,compared with WFC(P<0.05).YWXY provided better relief from symptoms of DSSS and better improvement in serum gastric fun

关键词： chronic atrophic gastritis Yiwei Xiaoyu granules Randomized clinical trial Weifuchun tablet Traditional Chinese medicine Helicobacter pylori

Research on the Orientated Effective Components of Huangqi in Huangqi Jianzhong Tang Against chronic atrophic gastritis Based on Multi-Spectrum–Effect Correlation

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World Journal of Traditional Chinese Medicine 2024年第2期10卷 244-253页

作者： Guo-Hong Wang Long-Fei Yang Shi-Wei Wang Yue-Tao Liu Department of Pharmacy Shanxi Traditional Chinese Medicine HospitalTaiyuanShanxi ProvinceChina Department of Pharmacy Shijazhuang Hospital of Traditional Chinese MedicineShijiazhuangHebeiChina Modern Research Center for Traditional Chinese Medicine Key Laboratory of Chemical Biology and Molecular Engineering of the Ministry of EducationTaiyuanShanxi ProvinceChina Key Laboratory of Effective Substances Research and Utilization in TCM of Shanxi Province Shanxi UniversityTaiyuanShanxi ProvinceChina

Objective: This study aimed to investigate the orientated effective components of Astragali Radix Huangqi(HQ) in HQ Jianzhong Tang(HQJZ), a classical formula of traditional Chinese medicine(TCM) used for treating chronic atrophic gastritis(CAG), using HQ as a monarch medicine. Materials and Methods: The spectra of HQJZ containing different polar parts of HQ were obtained using ultra-high-performance liquid chromatography-Q-Exactive mass spectrometry. Furthermore, the efficacy of HQJZ, which contains different polar parts of HQ, in treating rats with CAG was evaluated using traditional pharmacodynamic and nuclear magnetic resonance-based metabonomics. Grey relation analysis and partial least squares analysis were applied to analyze the spectrum–effect relationship and to screen out the orientated effective components related to HQ in the treatment of CAG. Results: Spectrum–effect relationship analysis showed that 24 compounds identified from the fingerprint spectrum were strongly correlated with efficacy. Compounds 8(calycosin-7-O-glc-6”-O-acetate), 9(3-hydroxy-9, 10-dimethoxyptercarpan), and 22(astragaloside II) were ranked among the top three. Conclusions: This study showed that integrating metabolomics and spectrum–effect relationship analysis is a powerful tool for obtaining orientated effective components of Chinese medicine in a given TCM formula.

关键词： Astragali radix chronic atrophic gastritis Huangqi Jianzhong Tang metabonomics spectrum–effect relationship

Efficacy of Shugan Hewei Therapy for chronic atrophic gastritis:A Systematic Review and Meta-Analysis

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Chinese Medicine and Culture 2022年第2期5卷 97-109页

作者： Jing-Bin Niu Xiao Gai De-Cai Yang Yi-Xin Zheng Yang Cao Chun-Mei Zhu Peng Qian Hai-Xia Yan Hua-Ling Song Guo-Ping Liu School of Basic Medical Sciences Shanghai University of Traditional Chinese MedicineShanghai 201203China School of Public Health Shanghai University of Traditional Chinese MedicineShanghai 201203China

Objective:Shugan Hewei therapy(SHT)acts to soothe the liver and harmonize the *** is a classical traditional Chinese medicine method widely used in China to treat chronic atrophic gastritis(CAG)due to liver qi invading the ***,the clinical effects of SHT remain *** aimed to evaluate the overall clinical effective rate and safety of SHT in treating ***:We used the Jadad scale and Cochrane Collaboration risk of bias tool to evaluate the methodological quality of studies investigating *** medical databases were searched to identify relevant *** data extraction and quality evaluation,27 randomized controlled trials,including 2,441 patients,were considered eligible for *** serious heterogeneity or publication bias was observed across the included *** used Revman 5.3 statistical software to evaluate the general clinical effective rate and safety of ***:The results showed that SHT was more effective(RR=1.25;95%CI[1.20,1.29];P<0.01)and safer(MD=0.24,95%CI[0.08,0.75];P<0.01)than control interventions comprising western medicine,Chinese patent medicine,and/or western medicine+Chinese patent *** with the control interventions,SHT resulted in greater improvements in the symptom scores for stomach distension and stomachache,serum gastrin level,histopathologic changes,Helicobacter pylori(HP)inhibition rate,and gastric mucosal ***:SHT was more effective and safer than control interventions for CAG.

关键词： Chinese herbal medicine chronic atrophic gastritis Efficacy Meta-analysis Shugan Hewei therapy

Regulatory effect of traditional Chinese medicines on signaling pathways of process from chronic atrophic gastritis to gastric cancer

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Chinese Herbal Medicines 2022年第1期14卷 5-19页

作者： Xinnan Liu Shuping Wang Jingyang Li Jingze Zhang Dailin Liu Tianjin Modern Innovation Chinese Medicine Technology Co. Ltd.Tianjin 300380China Tianjin University of Traditional Chinese Medicine Tianjin 301617China Department of Pharmacy Tianjin Provincial Corps HospitalChinese People’s Armed Police ForcesTianjin 300162China Logistics College of Chinese People’s Armed Police Forces Tianjin 300309China

chronic atrophic gastritis(CAG),a common disease of digestive system,is an extremely important cause of gastric cancer(GC).The occurrence and development of CAG involves the abnormality of multiple signaling *** Chinese medicines(TCMs)has the advantages of mild action,multi-target and small adverse reaction,etc.,which broadens the way for the treatment of the disease,and TCMs can play a therapeutic role by regulating multiple signaling *** this review,based on the related experiments of TCMs and Chinese herbal compounds in recent years,the related literatures were searched and 10 kinds of signaling pathways involved were summarized,in order to provide a reference for further research on reversing or delaying the progress of CAG and preventing gastric cancer.

关键词： chronic atrophic gastritis gastric cancer signaling pathway traditional Chinese medicines

Risk assessment models of integrative medicine indicators for malignant transformation of chronic atrophic gastritis:A registry study protocol

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Journal of Traditional Chinese Medical Sciences 2019年第3期6卷 218-225页

作者： Yue Liu Wanjuan Wang Yuan Li Fusheng Liu Li Zhang Tao Tang Mingxuan Zang Yin Zhang Xia Ding School of Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China Department of Gastroenterology Dongzhimen Hospital Affiliated to Beijing University of Chinese MedicineBeijing 100700China Department of Emergency Medicine Dongfang Hospital Affiliated to Beijing University of Chinese MedicineBeijing 100078China Department of Neurosurgery China-Japan Friendship HospitalBeijing 100029China Department of General Surgery China-Japan Friendship HospitalBeijing 100029China Department of Oncology Xiyuan Hospital Affiliated to China Academy of Chinese Medical SciencesBeijing 100091China Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing 100700China

Objective:Traditional Chinese medicine(TCM)and modern medicine have both been used in arresting malignant transformation of chronic atrophic gastritis(CAG)in China with good therapeutic ***,no studies have been undertaken to assess the risk of malignant transformation in CAG patients using both modern medicine and TCM *** study aimed to develop risk assessment models for malignant transformation of CAG combining indicators of both TCM and modern *** models will facilitate early warning and control of malignant transformation of CAG from the perspective of evidence-based integrative ***:In the proposed registry study,a total of 1000 eligible CAG patients will be recruited from four hospitals in China.A 10-year follow-up study will be conducted both on-site and off-site to track the events of malignant *** analysis and chi-squared tests will be used to perform the comparative analysis on the prevalence of malignant transformation events and indicators in TCM or modern medicine in different groups.A multivariate Cox proportional hazard model will be used to perform correlation analyses of malignant transformation events and factors of TCM or modern ***:The proposed study has been designed with a large sample size and long follow-up period,in which wide-ranging modern medicine and TCM indicators can be gathered over the whole process of malignant transformation of *** on this study,risk assessment models for malignant transformation ofCAGmaybe constructed fromthe perspective of integrative *** may provide clinicians and patients with an optimized early warning system as well as prevention strategies for malignant transformation of CAG.

关键词： chronic atrophic gastritis Malignant transformation Risk assessment Traditional Chinese medicine Protocol