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In vivo neuronal and astrocytic activation in somatosensory cortex by acupuncture stimuli

Neural Regeneration Research 2022年第11期17卷 2526-2529页

作者： Xiao-Yue Chang Kai Chen Tong Cheng Pui To Lai Li Zhang Kwok-Fai So Edward S.Yang Key Laboratory of CNS Regeneration(Minstry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Electrical and Electronic Engineering The University of Hong KongHong Kong Special Administrative RegionChina Center for Brain Science and Brain-Inspired Intelligence Guangdong-Hong Kong-Macao Greater Bay AreaGuangzhouGuangdong ProvinceChina Guangzhou Regenerative Medicine and Health Guangdong Laboratory GuangzhouGuangdong ProvinceChina State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina

Acupuncture is a medical treatment that has been widely pra cticed in China for over 3000 years,yet the neural mechanisms of acupuncture are not fully understood.We hypothesized that neurons and astrocytes act independently and synergistically under acupuncture stimulation.To investigate this,we used two-photon in vivo calcium reco rding to observe the effects of acupuncture stimulation at ST36(Zusanli)in mice.Acupuncture stimulation in peripheral acupoints potentiated calcium signals of pyramidal neurons and astrocytes in the somatosensory cortex and resulted in late-onset calcium transients in astrocytes.chemogenetic inhibition of neurons augmented the astrocytic activity.These findings suggest that acupuncture activates neuronal and astrocytic activity in the somatosensory co rtex and provide evidence for the involvement of both neurons and astrocytes in acupuncture treatment.

关键词： acupuncture astrocyte chemogenetic neuron N-methyl-D-aspartate receptor somatosensory cortex transient receptor potential A1 two-photon in vivo imaging

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chemogenetic stimulation of nigrostriatal and mesolimbic projections affects sleep-wake behavior in rat

Chemogenetic stimulation of nigrostriatal and mesolimbic pro...

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中国神经科学学会第十二届全国学术会议

作者： Mei-Hong Qiu Michael C.Chen Jun Lu Department of Neurobiology School of Basic Medical Science Fudan University Department of Neurology Beth Israel Deaconess Medical Center and Harvard Medical School Department of Pharmacology School of Basic Medical Science Fudan University

Dopamine plays a complex role in sleep-wake systems. The exact effect of dopamine on these behaviors may depend on the downstream target of dopamine pathways. Using selective chemogenetic stimulation in rats, we dissected midbrain dopaminergic nigrostriatal and mesolimbic pathways and their effects on sleep. chemogenetic stimulation of nigrostriatal pathways increased sleep and cortical EEG delta power, while chemogenetic stimulation of mesolimbic pathways decreased sleep and cortical EEG power. These results indicate that midbrain dopamine（DA） in the basal ganglia has distinct roles in sleep-wake regulation.

关键词： dopamine sleep-wake mesolimbic pathway nigrostriatal pathway chemogenetic

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The dynamics of memory retrieval and consolidation is regulated by brain states

The dynamics of memory retrieval and consolidation is regula...

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中国神经科学学会第十二届全国学术会议

作者： Jun Jiang Guang-Yu Wang Wenhan Luo Yang Lin Yi Hu Hong Xie Ji-Song Guan MOE Key Laboratory of Protein Sciences Center for Brain inspired Computing IDG/McGovern institute for Brain Research at Tsinghua School of Life Sciences Tsinghua University Center for Life Science Academy for Advanced Interdisciplinary Studies. Peking University

State-dependent learning（SDL） is a well-known phenomenon in psychology, where the memory retrieval is facilitated only when the brain state matches the state of encoding. SDL associated amnesia is widely observed in "fugue" states induced by drug, mood, somnambulism and in the multiple personality syndrome. However, the neuronal basis of SDL remains unknown. Here we showed that MK-801, a NMDA receptor antagonist, induced SDL of contextual fear memory in mice. Such MK-801 induced SDL was associated with inhibition of mammillary body（MB） and hippocampus. chemogenetic silencing of MB shifted the brain state similar to the MK-801 induced one to encode and recall the state-dependent memory by repressing activities in retrospenial cortex and inducing delta oscillations. Reconstitution of cortical delta waves facilitated memory retrieval in SDL. In addition, the neural activity in MB is repressed during slow wave sleep, creating the brain state for memory consolidation in neocortex. Thereby, we posit the MB-regulated activity level of hippocampus and neocortex is one of the major neural mechanisms underlying the state-dependent memory retrieval.

关键词： Mammillary body state-dependent learning neocortex two-photon microscopy immediate early gene hippocampus chemogenetic consolidation sleep

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Mammillary body regulates state-dependent learning

Mammillary body regulates state-dependent learning

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中国神经科学学会第十二届全国学术会议

作者： Jun Jiang Guang-Yu Wang Wenhan Luo Yang Lin Yi Hu Hong Xie Ji-Song Guan MOE Key Laboratory of Protein Sciences Center for Brain inspired Computing IDG/McGovern institute for Brain Research at Tsinghua School of Life Sciences Tsinghua University School of Life Sciences Shanghai Tech University Center for Life Science Academy for Advanced Interdisciplinary Studies. Peking University

State-dependent learning（SDL） describes a phenomenon, where the memory retrieval is facilitated only when the brain state matches the state of encoding. SDL associated amnesia is widely observed in "fugue" states induced by drug, mood, somnambulism and in hippocampus damaged patient. However, the neuronal basis of SDL remains unknown. Here we showed that SDL was associated with inhibition of mammillary body（MB） and hippocampus. chemogenetic silencing of MB shifted the brain state from hippocampus "on state" to "off state" in awake mice, regulating the successful retrieval of drug-induced state-dependent memory. MB is inactive during sleep, promoting memory consolidation. While artificially activating of MB impaired system consolidation, inhibiting of MB induced delta oscillations in neocortex and facilitated system consolidation of fear memory. Thereby, we posit the MB-regulated activity level of hippocampus-neocortex system underlying the neural mechanisms of state-dependent memory. This novel neural pathway regulates system consolidation of memory during sleep.

关键词： Mammillary body state-dependent learning neocortex two-photon microscopy immediate early gene hippocampus chemogenetic sleep system consolidation

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