In vivo neuronal and astrocytic activation in somatosensory cortex by acupuncture stimuli

作     者：Xiao-Yue Chang Kai Chen Tong Cheng Pui To Lai Li Zhang Kwok-Fai So Edward S.Yang Xiao-Yue Chang;Kai Chen;Tong Cheng;Pui To Lai;Li Zhang;Kwok-Fai So;Edward S.Yang

作者机构：Key Laboratory of CNS Regeneration(Minstry of Education)Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Electrical and Electronic EngineeringThe University of Hong KongHong Kong Special Administrative RegionChina Center for Brain Science and Brain-Inspired IntelligenceGuangdong-Hong Kong-Macao Greater Bay AreaGuangzhouGuangdong ProvinceChina Guangzhou Regenerative Medicine and Health Guangdong LaboratoryGuangzhouGuangdong ProvinceChina State Key Laboratory of Brain and Cognitive ScienceLi Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2022年第17卷第11期

页      面：2526-2529页

核心收录：

学科分类：1005[医学-中医学] 100512[医学-针灸推拿学] 10[医学] 

基　　金：National Key Research and Development Program of China,No.2016YFC1306702(to KFS and LZ) the National Natural Science Foundation of China,No.81771455(to KFS) Science and Technology Program of Guangdong Province of China,No.2018B030334001(to KFS) the Natural Science Foundation of Guangdong of China,No.2019A1515011772(to LZ) 

主　　题：acupuncture astrocyte chemogenetic neuron N-methyl-D-aspartate receptor somatosensory cortex transient receptor potential A1 two-photon in vivo imaging 

摘      要：Acupuncture is a medical treatment that has been widely pra cticed in China for over 3000 years,yet the neural mechanisms of acupuncture are not fully *** hypothesized that neurons and astrocytes act independently and synergistically under acupuncture *** investigate this,we used two-photon in vivo calcium reco rding to observe the effects of acupuncture stimulation at ST36(Zusanli)in *** stimulation in peripheral acupoints potentiated calcium signals of pyramidal neurons and astrocytes in the somatosensory cortex and resulted in late-onset calcium transients in *** inhibition of neurons augmented the astrocytic *** findings suggest that acupuncture activates neuronal and astrocytic activity in the somatosensory co rtex and provide evidence for the involvement of both neurons and astrocytes in acupuncture treatment.