Chemogenetic stimulation of nigrostriatal and mesolimbic projections affects sleep-wake behavior in rat
作者单位：Department of Neurobiology School of Basic Medical Science Fudan University Department of Neurology Beth Israel Deaconess Medical Center and Harvard Medical School Department of Pharmacology School of Basic Medical Science Fudan University
会议名称：《中国神经科学学会第十二届全国学术会议》
会议日期：2017年
学科分类：0710[理学-生物学] 07[理学] 071006[理学-神经生物学]
关 键 词：dopamine sleep-wake mesolimbic pathway nigrostriatal pathway chemogenetic
摘 要：Dopamine plays a complex role in sleep-wake systems. The exact effect of dopamine on these behaviors may depend on the downstream target of dopamine pathways. Using selective chemogenetic stimulation in rats, we dissected midbrain dopaminergic nigrostriatal and mesolimbic pathways and their effects on sleep. Chemogenetic stimulation of nigrostriatal pathways increased sleep and cortical EEG delta power, while chemogenetic stimulation of mesolimbic pathways decreased sleep and cortical EEG power. These results indicate that midbrain dopamine（DA） in the basal ganglia has distinct roles in sleep-wake regulation.