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CCS Chemistry 2022年第12期4卷 3715-3723页

作者： Rongchen Wang Kai Yin Muye Ma Tianli Zhu Jinzhu Gao Jie Sun Xuemei Dong Chengjun Dong Xianfeng Gu He Tian Chunchang Zhao Key Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center Institute of Fine ChemicalsSchool of Chemistry and Molecular EngineeringFrontiers Science Center for Materiobiology and Dynamic ChemistryEast China University of Science and TechnologyShanghai 200237 Department of Medicinal Chemistry School of PharmacyFudan UniversityShanghai 201203

Optical imaging with molecular probes is becoming an essential tool for advancing biological research and clinical ***,most currently available molecular probes show limited sensitivity,specificity,and accuracy due to their typical responsiveness to a single stimulation for biomarker-based *** this study,we develop a novel molecular probe that shows alkaline phosphatase(ALP)-instructed sensitive responsiveness to hydrogen sulfide for accurate cancer imaging and *** designed probe in an aggregated state under physiological conditions bears negatively charged surfaces,giving poor optical response to H_(2)*** ALP-mediated dephosphorylation reaction yields an assembled product with a positively charged surface,affording significantly aggregation-enhanced responsiveness to H_(2)S with light-up NIR fluorescence at 755 *** charge reversal of assembled probe from negative to positive plays a vital role in allowing precise visualization and differentiation of cancers based on differences in ALP upregulation and H_(2)S *** envisage that our charge-reversal strategy for multiple-parameter-activated molecule probes will facilitate boosting the specificity and precision of cancer imaging.

关键词： near-infrared fluorescence activatable probe alkaline phosphatase H_(2)S cancer imaging

Current trends of artificial intelligence in cancer imaging

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Artificial Intelligence in Medical imaging 2020年第3期1卷 87-93页

作者： Francesco Verde Valeria Romeo Arnaldo Stanzione Simone Maurea Department of Advanced Biomedical Sciences University of Naples"Federico II"Napoli 80131Italy

In this editorial,we discussed the current research status of artificial intelligence(AI)in Oncology,reviewing the basics of machine learning(ML)and deep learning(DL)techniques and their emerging applications on clinical and imaging cancer *** growing amounts of available“big data”coupled to the increasing computational power have enabled the development of computerbased systems capable to perform advanced tasks in many areas of clinical care,especially in medical *** is a branch of data science that allows the creation of computer algorithms that can learn and make predictions without prior *** is a subgroup of artificial neural network algorithms configurated to automatically extract features and perform high-level tasks;convolutional neural networks are the most common DL models used in medical image *** methods have been proposed in many areas of oncology granting promising results in radiology-based clinical *** detail,we explored the emerging applications of AI in oncological risk assessment,lesion detection,characterization,staging,and therapy *** issues such as the lack of reproducibility and generalizability need to be addressed to fully implement AI systems in clinical ***,AI impact on cancer imaging has been driving the shift of oncology towards a precision diagnostics and personalized cancer treatment.

关键词： Artificial intelligence Machine learning Deep learning Oncology Medical imaging cancer imaging

Tumor microenvironment-responsive contrast agents for specific cancer imaging:a narrative review

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Journal of Bio-X Research 2020年第4期3卷 144-156页

作者： Xianwen Wang Xiaoyan Zhong Huali Lei Nailin Yang Xiang Gao Liang Cheng Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices Department of Toxicology School of Public HealthJiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric DiseasesMedical College The Second Affiliated Hospital of Soochow University SuzhouJiangsu ProvinceChina

Molecular imaging is of great significance for early diagnosis and timely treatment of cancer and disease,as well as basic medical and biological *** personalized cancer treatment has become increasingly popular,the demand for more advanced imaging technologies has also significantly *** advantage of differences between the tumor microenvironment and normal tissue cells,tumor microenvironment-responsive or"turn-on"contrast agents have a higher signal-to-noise ratio and lower background interference compared with"turn-off"probes,which can remarkably improve the performance of tumor ***,tumor microenvironment-responsive contrast agents can not only detect changes in the tumor microenvironment,but also have important significance for tumor diagnosis,prediction of invasion potential,evaluation of treatment effectiveness,planning of therapeutic regimens,and tumor ***,this review focuses on recent research progress of tumor microenvironment-responsive intelligent probes,and highlights future research directions of tumor microenvironment-responsive contrast agents for precision diagnostics.

关键词： cancer imaging cancer treatment contrast agents diagnosis tumor microenvironment

Biomimetic manganese-based theranostic nanoplatform for cancer multimodal imaging and twofold immunotherapy

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Bioactive Materials 2023年第1期19卷 237-250页

作者： Yuyue Zhao Yuanwei Pan Kelong Zou Zhou Lan Guowang Cheng Qiuying Mai Hao Cui Qianfang Meng Tongkai Chen Lang Rao Limin Ma Guangtao Yu Stomatological Hospital Southern Medical UniversityGuangzhou510280China Institute of Biomedical Health Technology and Engineering Shenzhen Bay LaboratoryShenzhen518132China Departments of Diagnostic Radiology SurgeryChemical and Biomolecular Engineeringand Biomedical EngineeringYong Loo Lin School of Medicine and Faculty of EngineeringNational University of SingaporeSingapore119074Singapore Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhou510405China Medical Research Center Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou510080China

The limited clinical response and serious side effect have been challenging in cancer immunotherapy resulting from immunosuppressive tumor microenvironment(TME)and inferior drug ***,an active targeting TME nanoplatform capable of revising the immunosuppressive TME microenvironment is ***,gold nanorods(GNRs)are covered with silica dioxide(SiO_(2))and then coated manganese dioxide(MnO_(2))to obtain GNRs@SiO_(2)@MnO_(2)(GSM).Myeloid-derived suppressor cells(MDSCs)membrane is further camouflaged on the surface of GSM to obtain GNRs@SiO_(2)@MnO_(2)@MDSCs(GSMM).In this system,GSMM inherits active targeting TME capacity of *** localized surface plasmon resonance of GNRs is developed in near-infraredⅡwindow by MnO_(2)layer coating,realizing NIR-Ⅱwindow photothermal imaging and photoacoustic imaging of *** on the release of Mn^(2+)in acidic TME,GSMM can be also used for magnetic resonance *** cancer cells,Mn^(2+)catalyzes H_(2)O_(2)into·OH for(chemodynamic therapy)CDT leading to activate cGAS-STING,but also directly acts on STING inducing secretion of typeⅠinterferons,pro-inflammatory cytokines and ***,photothermal therapy and CDT-mediated immunogenic cell death of tumor cells can further enhance anti-tumor immunity via exposure of CRT,HMGB1 and *** summary,our nanoplatform realizes multimodal cancer imaging and dual immunotherapy.

关键词： Biomimetic Manganese ions The second near-infrared window cancer imaging Immunotherapy

imaging in translational cancer research

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cancer Biology & Medicine 2022年第11期19卷 1565-1585页

作者： Felix T.Kurz Heinz-Peter Schlemmer Department of Radiology German Cancer Research CenterHeidelberg 69120Germany

This review is aimed at presenting some of the recent developments in translational cancer imaging research,with a focus on novel,recently established,or soon to be established cross-sectional imaging techniques for computed tomography(CT),magnetic resonance imaging(MRI),and positron-emission tomography(PET)imaging,including computational investigations based on machine-learning techniques.

关键词： cancer imaging computed tomography(CT) magnetic resonance imaging(MRI) positron emission tomography(PET) cross-sectional imaging

Aptamer-Anchored Rubrene-Loaded Organic Nanoprobes for cancer Cell Targeting and imaging

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CCS Chemistry 2019年第3期1卷 251-260页

作者： Yuanyuan Li Chuansheng Li Tao Jiang Lihua Zhou Pengfei Zhang Ryan T.K.Kwok Jacky Wing Yip Lam Ping Gong Lintao Cai Ben Zhong Tang Department of Chemistry The Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and ReconstructionInstitute for Advanced StudyDepartment of Chemical and Biological EngineeringThe Hong Kong University of Science and TechnologyClear Water BayKowloonChina HKUST Shenzhen Research Institute Shenzhen 518057China Guangdong Key Laboratory of Nanomedicine CAS Key Laboratory of Health InformaticsShenzhen Bioactive Materials Engineering Lab for MedicineInstitute of Biomedicine and Biotechnology.Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Department of Pharmaceutical Sciences Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China Dongguan Key Laboratory of Drug Design and Formulation Technology Key Laboratory for NanomedicineGuangdong Medical UniversityDongguan 523808China Center for Aggregation-Induced Emission NSFC Center for Luminescence from Molecular AggregatesSCUT-HKUST Joint Research LaboratoryState Key Laboratory of Luminescent Materials and DevicesSouth China University of TechnologyGuangzhou 510640China

Fluorescence imaging has become an indispensable technique in cancer research because it can reveal informative molecular,cellular,anatomical,and func-tional *** of advanced fluores-cent probes with superior sensitivity and biological selectivity for fluorescence imaging is thus *** move forward in this direction,we developed an easy self-assembly method for fabricating apta-mer-anchored rubrene-loaded organic fluorescent *** aptamer-modified organic nanop-robes integrated the best features of the organic light-emitting materials and the aptamers,thus endowing them with excellent cell-targeting capabil-ity,high stability,and good *** using this general method,a variety of biocompatible and highly bright organic fluorescent nanoprobes based on novel organic light-emitting materials with specific recognition could be easily constructed for real-time biosensing and long-term biomedical imaging.

关键词： aptamer organic nanoprobes fluores-cence cancer imaging biomedicine

Microwave-responsive gadolinium metal-organic frameworks nanosystem for MRI-guided cancer thermotherapy and synergistic immunotherapy

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Bioactive Materials 2024年第3期33卷 532-544页

作者： Hao Cui Yu-Yue Zhao Qiong Wu Yan You Zhou Lan Ke-Long Zou Guo-Wang Cheng Hao Chen Yan-Hua Han Yan Chen Xiang-Dong Qi Xian-Wei Meng Li-Min Ma Guang-Tao Yu Stomatological Hospital School of StomatologySouthern Medical UniversityGuangzhou510280China Medical Research Center Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou510080China Laboratory of Controllable Preparation and Application of Nanomaterials Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing100190China Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhou510405China Department of Plastic Surgery Zhujiang HospitalSouthern Medical UniversityGuangzhou510280China Department of Endodontics Southern Medical University-Shenzhen Stomatology Hospital(Pingshan)Shenzhen518118China

The clinical application of cancer immunotherapy is unsatisfied due to low response rates and systemic immune-related adverse *** hyperthermia can be used as a synergistic immunotherapy to amplify the antitumor ***,we designed a Gd-based metal-organic framework(Gd-MOF)nanosystem for MRI-guided thermotherapy and synergistic immunotherapy,which featured high performance in drug loading and tumor tissue *** PD-1 inhibitor(aPD-1)was initially loaded in the porous Gd-MOF(Gd/M)***,the phase change material(PCM)and the cancer cell membrane were further sequentially modified on the surface of Gd/MP to obtain Gd-MOF@aPD-1@CM(Gd/MPC).When entering the tumor microenvironment(TME),Gd/MPC induces immunogenic death of tumor cells through microwave thermal responsiveness,improves tumor suppressive immune microenvironment and further enhances anti-tumor ability of T cells by releasing ***,Gd/MPC can be used for contrast-enhanced *** data revealed that the downregulation of MSK2 in cancer cells leads to the downregulation of c-fos and c-jun,and ultimately leads to the apoptosis of cancer cells after *** general,Gd/MPC nanosystem not only solves the problem of system side effect,but also achieves the controlled drug release via PCM,providing a promising theranostic nanoplatform for development of cancer combination immunotherapy.

关键词： Immunotherapy Microwave Metal-organic framework Thermotherapy cancer imaging

A metabolic acidity-activatable calcium phosphate probe with fluorescence signal amplification capabilities for non-invasive imaging of tumor malignancy

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Science Bulletin 2022年第3期67卷 288-298页

作者： Qian Jia Ruili Zhang Yongdong Wang Haohao Yan Zheng Li Yanbin Feng Yu Ji Zuo Yang Yang Yang Kanyi Pu Zhongliang Wang Laboratory of Molecular imaging and Translational Medicine(MITM) Engineering Research Center of Molecular&NeuroimagingMinistry of EducationSchool of Life Science and TechnologyXidian UniversityXi’an 710126China Academy of Advanced Interdisciplinary Research Xidian UniversityXi’an 710071China Department of Thoracic Surgery Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghai 200433China School of Materials Science and Engineering Tongji UniversityShanghai 201804China School of Chemical and Biomedical Engineering Nanyang Technological UniversitySingapore 637457Singapore

Dysregulated energy metabolism has recently been recognized as an emerging hallmark of *** cells,which are characterized by abnormal glycolysis,exhibit a lower extracellular pH(6.5–7.0)than nor-mal tissues(7.2–7.4),providing a promising target for tumor-specific imaging and ***,most pH-sensitive materials are unable to distinguish such a subtle pH difference owing to their wide and continuous pH-responsive *** this study,we developed an efficient strategy for the fabrication of a tumor metabolic acidity-activatable calcium phosphate(CaP)fluorescent probe(termed MACaP9).Unlike traditional CaP-based biomedical nanomaterials,which only work within more acidic organelles,such as endosomes and lysosomes(pH 4.0–6.0),MACaP9 could not only specifically respond to the tumor extra-cellular pH but also rapidly convert pH variations into a distinct fluorescence signal to visually dis-tinguish tumor from normal *** superior sensitivity and specificity of MACaP9 enabled high-contrast visualization of a broad range of tumors,as well as small tumor lesions.

关键词： Calcium phosphate Activatable probe cancer imaging Tumor microenvironment Tumor metabolism

Surface-enhanced Raman nanoparticles for tumor theranostics applications

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Acta Pharmaceutica Sinica B 2018年第3期8卷 349-359页

作者： Yangyang Li Qiaolin Wei Fei Ma Xin Li Fengyong Liu Min Zhou Department of Nuclear Medicine & Key Laboratory of cancer Prevention and Intervention National Ministry of Education The Second Affiliated Hospital School of Medicine Zhejiang University Institute of Translational Medicine Zhejiang University Department of Interventional Radiology Chinese PLA General Hospital State Key Laboratory of Modern Optical Instrumentations Zhejiang University

Raman spectroscopy, amplified by surface-enhanced Raman scattering(SERS) nanoparticles,can provide an in vivo imaging modality due to its high molecular specificity, high sensitivity, and negligible autofluorescence. The basis, composition, and methodologies developed for SERS nanoparticles are herein described. The research hotspots that are the focus in this paper are tumor imaging-guided theranostics and biosensing. The next breakthrough may be the development of biocompatible SERS nanoparticles and spectroscopic devices for clinical applications.

关键词： Raman spectroscopy SERS cancer imaging Nanoparticles Theranostics

Optical tweezer and TIRF microscopy for single molecule manipulation of RNA/DNA nanostructures including their rubbery property and single molecule counting

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Biophysics Reports 2021年第6期7卷 449-474页

作者： Chiran Ghimire Peixuan Guo Center for RNA Nanobiotechnology and Nanomedicine College of Pharmacy 3. Dorothy M. Davis Heart and Lung Research Institute 4. College of Medicine 5. James Compréhensive cancer Center The Ohio State University

Life science is often focused on the microscopic level. Single-molecule technology has been used to observe components at the micro-or nanoscale. Single-molecule imaging provides unprecedented information about the behavior of individual molecules in contrast to the information from ensemble methods that average the information of many molecules in various states. A typical feature of living systems is motion. The lack of synchronicity of motion biomachines in living systems makes it challenging to image the motion process with high resolution. Thus, single-molecule technology is especially useful for real-time study on motion mechanism of biomachines, such as viral DNA packaging motor, or other ATPases. The most common optical instrumentations in single-molecule studies are optical tweezers and single molecule total internal refection fluorescence microscopy(sm TIRF). Optical tweezers are the force-based technique. The analysis of RNA using optical tweezer has led to the discovery of the rubbery or amoeba property of RNA nanoparticles for compelling vessel extravasation to enhance tumor targeting and fast renal excretion. The rubbery property of RNA lends mechanistic evidence for RNAs use as an ideal reagent in cancer treatment with undetectable toxicity. Single molecule photobleaching allows for the direct counting of biomolecules. This technique was invented for single molecule counting of RNA in the phi29 DNA packaging motor to resolve the debate between five and six copies of RNA in the motor. The technology has subsequently extended to counting components in biological machines composed of protein, DNA, and other macromolecules. In combination with statistical analysis, it reveals biomolecular mechanisms in detail and leads to the development of ultra-sensitive sensors in diagnosis and forensics. This review focuses on the applications of optical tweezers and fluorescence-based techniques as single-molecule technologies to resolve mechanistic questions related

关键词： Stoichiometry Passive targeting Photobleaching Renal excretion cancer imaging pRNA Bacteriophage Phi29 DNA packaging motor Portal vertex Organ accumulation Single layer patterned arrays