Microwave-responsive gadolinium metal-organic frameworks nanosystem for MRI-guided cancer thermotherapy and synergistic immunotherapy
作者机构：Stomatological HospitalSchool of StomatologySouthern Medical UniversityGuangzhou510280China Medical Research CenterGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou510080China Laboratory of Controllable Preparation and Application of NanomaterialsTechnical Institute of Physics and ChemistryChinese Academy of SciencesBeijing100190China Science and Technology Innovation CenterGuangzhou University of Chinese MedicineGuangzhou510405China Department of Plastic SurgeryZhujiang HospitalSouthern Medical UniversityGuangzhou510280China Department of EndodonticsSouthern Medical University-Shenzhen Stomatology Hospital(Pingshan)Shenzhen518118China
出 版 物：《Bioactive Materials》 (生物活性材料（英文）)
年 卷 期：2024年第33卷第3期
页 面：532-544页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：support from National Natural Science Foundation of China Southern Medical University Excellent Youth Scholars Training Program[2020YQPY008] Stomatological Hospital of Southern Medical University Startup Funds[No.PY2020001,PY2019026] Natural Science Foundation of Guang dong Province(2023A1515011604) The Fundamental Research Funds for the Central Universities(2022ZYGXZR042) the High-level Hospital Construction Project(KJ012019100)for financial support
主 题：Immunotherapy Microwave Metal-organic framework Thermotherapy Cancer imaging
摘 要：The clinical application of cancer immunotherapy is unsatisfied due to low response rates and systemic immune-related adverse *** hyperthermia can be used as a synergistic immunotherapy to amplify the antitumor ***,we designed a Gd-based metal-organic framework(Gd-MOF)nanosystem for MRI-guided thermotherapy and synergistic immunotherapy,which featured high performance in drug loading and tumor tissue *** PD-1 inhibitor(aPD-1)was initially loaded in the porous Gd-MOF(Gd/M)***,the phase change material(PCM)and the cancer cell membrane were further sequentially modified on the surface of Gd/MP to obtain Gd-MOF@aPD-1@CM(Gd/MPC).When entering the tumor microenvironment(TME),Gd/MPC induces immunogenic death of tumor cells through microwave thermal responsiveness,improves tumor suppressive immune microenvironment and further enhances anti-tumor ability of T cells by releasing ***,Gd/MPC can be used for contrast-enhanced *** data revealed that the downregulation of MSK2 in cancer cells leads to the downregulation of c-fos and c-jun,and ultimately leads to the apoptosis of cancer cells after *** general,Gd/MPC nanosystem not only solves the problem of system side effect,but also achieves the controlled drug release via PCM,providing a promising theranostic nanoplatform for development of cancer combination immunotherapy.
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