Tumor microenvironment-responsive contrast agents for specific cancer imaging:a narrative review

作     者：Xianwen Wang Xiaoyan Zhong Huali Lei Nailin Yang Xiang Gao Liang Cheng Wang Xianwen;Zhong Xiaoyan;Lei Huali;Yang Nailin;Gao Xiang;Cheng Liang

作者机构：Institute of Functional Nano&Soft Materials(FUNSOM)Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices Department of ToxicologySchool of Public HealthJiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric DiseasesMedical College The Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina 

出 版 物：《Journal of Bio-X Research》 (生物组学研究杂志（英文）)

年 卷 期：2020年第3卷第4期

页      面：144-156页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(No.52072253) Collaborative Innovation Center of Suzhou Nano Science and Technology,and the State Key Laboratory of Radiation Medicine and Protection(No.GZK1201810) XW was supported a Project Funded for Postgraduate Research&Practice Innovation Program of Jiangsu Province(No.2019 SJKY19_1923) 

主　　题：cancer imaging cancer treatment contrast agents diagnosis tumor microenvironment 

摘      要：Molecular imaging is of great significance for early diagnosis and timely treatment of cancer and disease,as well as basic medical and biological *** personalized cancer treatment has become increasingly popular,the demand for more advanced imaging technologies has also significantly *** advantage of differences between the tumor microenvironment and normal tissue cells,tumor microenvironment-responsive orturn-oncontrast agents have a higher signal-to-noise ratio and lower background interference compared withturn-offprobes,which can remarkably improve the performance of tumor ***,tumor microenvironment-responsive contrast agents can not only detect changes in the tumor microenvironment,but also have important significance for tumor diagnosis,prediction of invasion potential,evaluation of treatment effectiveness,planning of therapeutic regimens,and tumor ***,this review focuses on recent research progress of tumor microenvironment-responsive intelligent probes,and highlights future research directions of tumor microenvironment-responsive contrast agents for precision diagnostics.