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Supramolecular host-guest nanosystems for overcoming cancer drug resistance

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cancer drug resistance 2023年第4期6卷 805-827页

作者： Sha Wu Miaomiao Yan Minghao Liang Wenzhi Yang Jingyu Chen Jiong Zhou Department of Chemistry College of SciencesNortheastern UniversityShenyang 110819LiaoningChina Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and Applications Jinan UniversityGuangzhou 510632GuangdongChina

cancer drug resistance has become one of the main challenges for the failure of chemotherapy,greatly limiting the selection and use of anticancer drugs and dashing the hopes of cancer *** emergence of supramolecular host-guest nanosystems has brought the field of supramolecular chemistry into the nanoworld,providing a potential solution to this *** with conventional chemotherapeutic platforms,supramolecular host-guest nanosystems can reverse cancer drug resistance by increasing drug uptake,reducing drug efflux,activating drugs,and inhibiting DNA ***,we summarize the research progress of supramolecular host-guest nanosystems for overcoming cancer drug resistance and discuss the future research direction in this *** is hoped that this review will provide more positive references for overcoming cancer drug resistance and promoting the development of supramolecular host-guest nanosystems.

关键词： Supramolecular nanosystems host-guest interaction cancer drug resistance

New mechanisms of multidrug resistance: an introduction to the cancer drug resistance special collection

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cancer drug resistance 2023年第3期6卷 590-595页

作者： Michael M.Gottesman Robert W.Robey Suresh V.Ambudkar Laboratory of Cell Biology Center for Cancer ResearchNational Cancer InstituteNational Institutes of HealthBethesdaMD 20892USA

cancer drug resistance publishes contributions to understanding the biology and consequences of mechanisms that interfere with successful treatment of cancer. Since virtually all patients who die of metastatic cancer have multidrug-resistant tumors, improved treatment will require an understanding of the mechanisms of resistance to design therapies that circumvent these mechanisms, exploit these mechanisms, or inactivate these multidrug resistance mechanisms. One example of a resistance mechanism is the expression of ATP-binding cassette efflux pumps, but unfortunately, inhibition of these transporters has not proved to be the solution to overcome multidrug resistance in cancer. Other mechanisms that confer multidrug resistance, and the confluence of multiple different mechanisms (multifactorial multidrug resistance) have been identified, and it is the goal of this Special Collection to expand this catalog of potential multidrug resistance mechanisms, to explore novel ways to overcome resistance, and to present thoughtful reviews on the problem of multidrug resistance in cancer.

关键词： cancer drug resistance multidrug resistance ABC transporters novel mechanisms of drug resistance

The importance of epithelial-mesenchymal transition and autophagy in cancer drug resistance

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cancer drug resistance 2020年第1期3卷 38-47页

作者： Charlotte Hill Yihua Wang School of Biological Sciences Faculty of Environmental and Life SciencesUniversity of SouthamptonSouthampton SO171BJUK Institute for Life Sciences University of SouthamptonSouthampton SO171BJUK

Epithelial-mesenchymal transition(EMT)and autophagy are both known to play important roles in the development of ***,these processes are now being utilised as targets for *** is globally one of the leading causes of death,and,despite many advances in treatment options,patients still face many *** resistance in cancer-therapy is a large problem,and both EMT and autophagy have been shown to ***,given the context-dependent role of these processes and the complexity of the interactions between them,elucidating how they both act alone and interact is *** this review,we provide insight into the current landscape of the interactions of autophagy and EMT in the context of malignancy,and how this ultimately may affect drug resistance in cancer therapy.

关键词： Epithelial-mesenchymal transition autophagy cancer drug resistance metastasis therapy

MicroRNAs and cancer drug resistance: over two thousand characters in search of a role

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cancer drug resistance 2019年第3期2卷 618-633页

作者： Bruno Costa Gomes Jose Rueff António Sebastião Rodrigues Centre for Toxicogenomics and Human Health GeneticsOncology and Human ToxicologyNOVA Medical SchoolUniversidade Nova de LisboaLisboa 1150-008Portugal

MicroRNAs(miRNAs),a group of small regulatory noncoding RNAs,transformed our thinking on gene *** than two thousand human miRNAs have been identified thus *** bind imperfectly to the 3’-untranslated region of target mRNA and have been involved in several pathological conditions including *** fact,major hallmarks of cancer,such as the cell cycle,cell proliferation,survival and invasion are modulated by *** drug resistance(CDR)has also been described as being modulated by *** remains a burden for cancer therapy and patients’outcome,often resulting in more aggressive tumours that tend to metastasize to distant *** this review we discuss the role of miRNAs influencing drug metabolism and drug influx/efflux,two important mechanisms of CDR.

关键词： MicroRNAs gene regulation cancer drug resistance drug transporters drug metabolism

Exploring near-infrared absorbing nanocarriers to overcome cancer drug resistance

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cancer drug resistance 2020年第3期3卷 302-333页

作者： Siwei Chu Ursula Stochaj Department of Physiology Faculty of MedicineMcGill UniversityMontreal H3G1Y6QuebecCanada.

One of the major obstacles of successful cancer therapy is cancer drug *** unique tools and applications developed by nanomedicine provide new approaches to surmount this common limitation of current treatment *** that absorb light in the near-infrared spectrum are particularly suitable for this *** nanocarriers can produce heat,release drugs or stimulate the production of physiologically relevant compounds when illuminated with near-infrared *** current review summarizes the causes contributing to cancer multidrug *** major types of nanocarriers that have been developed in recent years to overcome these hurdles are *** focus on nanoparticles that are responsive to near-infrared light and suitable to surmount cancer multidrug *** review concludes with the bottlenecks that currently restrict the use of nanocarriers in the clinic and an outlook on future directions.

关键词： cancer drug resistance chemotherapy nanomedicine near-infrared light combination therapy photothermal therapy photodynamic therapy controlled drug release

Bulbine frutescens phytochemicals as novel ABC-transporter inhibitor:a molecular docking and molecular dynamics simulation study

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Journal of cancer Metastasis and Treatment 2021年第1期7卷 20-32页

作者： Prem Prakash Kushwaha Santosh Kumar Maurya Amit Singh Kumari Sunita Prajapati Atul Kumar Singh Mohd Shuaib Shashank Kumar Molecular Signaling&drug Discovery Laboratory Department of BiochemistryCentral University of PunjabBathinda 151401India Department of Computational Sciences Central University of PunjabBathinda 151401India.

Aim:The present in silico study aimed to evaluate the ATP-binding cassette(ABC)transporter inhibition potential of Bulbine frutescens(***)***:Several previous studies and databases were used to retrieve the ligands and target protein *** molecular docking study was performed using the Auto Dock Tools,and the GROMACS package was applied to accomplish molecular dynamics ***:Utilizing the molecular docking and simulation approach,~25 phytochemicals were screened against the ABC transporter *** score analysis revealed that *** phytochemical 4’-Demethylknipholone 2’-β-D-glucopyranoside exhibited strong binding on the ABC transporter protein with a minimum binding score-9.8 kcal/mol in comparison to the standard ABC transporter inhibitor diltiazem(-6.86 kcal/mol).Furthermore,molecular dynamics simulation for 4’-Demethylknipholone 2’-β-D-glucopyranoside showed an acceptable root mean square deviation,radius of gyration,root mean square fluctuation,and hydrogen bond,in addition to other lead ***:The in-silico study demonstrated that *** phytochemical 4’-Demethylknipholone 2’-β-D-glucopyranoside possesses anti-drug resistance properties and requires further testing in preclinical settings.

关键词： cancer drug resistance ABC-transporter natural inhibitors Bulbine frutescens MM-GBSA

Clinical significance of the loss of CD20 antigen on tumor cells in patients with relapsed or refractory follicular lymphoma

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cancer drug resistance 2021年第3期4卷 710-718页

作者： Jean-Marie Michot Alice Buet-Elfassy Maxime Annereau Julien Lazarovici Alina Danu Clémentine Sarkozy Claude Chahine Camille Bigenwald Jacques Bosq Julien Rossignol Patricia Romano-Martin Capucine Baldini David Ghez Peggy Dartigues Christophe Massard Vincent Ribrag Gustave Roussy UniversitéParis-SaclayDépartement des Innovations Thérapeutiques et Essais PrécocesVillejuif 94800France Gustave Roussy UniversitéParis-SaclayPharmacy DepartementVillejuif 94800France Gustave Roussy UniversitéParis-SaclayDepartement of HematologyVillejuif 94800France Gustave Roussy UniversitéParis-SaclayDepartement of PathologyVillejuif 94800France

Aim:Anti-CD20 monoclonal antibody is a cornerstone therapy for follicular *** anti-CD20 therapy,a potential decrease in CD20 antigen,and therefore a loss of the tumor target might be ***,the incidence and clinical significance of CD20 loss on tumor cells in patients with relapsed or refractory follicular lymphoma are *** study aims to investigate the incidence and outcome of patients with relapsed or refractory follicular lymphoma patients harboring the loss of the tumor target,***:All consecutive adult patients with relapsed or refractory follicular lymphoma referred to the Early drug Department at Gustave Roussy were *** main objectives were to assess the incidence and prognosis of the loss in expression of CD20 antigen on the surface of tumor cells on patient ***:Over the study period 2013-2018,131 patients were screened for clinical trials with B-cell malignancies in the early drug department of Gustave Roussy in ***-four patients presented with relapsed or refractory follicular lymphoma and 32 had tumor biopsies at the time of relapse that were retained for *** median(range)age was 67.5 years(55.3-75.3)and the median number of prior anti-cancer systemic therapies was 3(2-4).At the time of relapse,CD20 expression was positive in 84%of tumors(n=27)and negative in 16%of tumors(n=5).At a median follow-up of 18.3(0.6-83.3)months,CD20 negativity was associated with a poorer prognosis with a median overall survival of 8.9 months(95%CI:2.4-19.1)in comparison to CD20 positive patients(28.3 months,95%CI:25.1-75.3 months,P=0.019).Conclusion:The loss of the tumor target antigen,CD20,occurred in 16%of patients with relapse or refractory follicular *** to confounding factors in patients who received anti-CD20 immunotherapy,it was not possible to formally establish the prognostic significance of CD20 ***,we suggest that a check for CD20 antigen positivity nevertheless

关键词： Follicular lymphoma CD20 tumor antigen anti-CD20 monoclonal antibody cancer drug resistance

Cell-mediated and cell membrane-coated nanoparticles for drug delivery and cancer therapy

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cancer drug resistance 2020年第4期3卷 879-911页

作者： Serkan Yaman Uday Chintapula Edgar Rodriguez Harish Ramachandramoorthy Kytai T.Nguyen Department of Bioengineering University of Texas at ArlingtonArlingtonTX 76010USA Joint Bioengineering Program University of Texas Southwestern Medical CenterDallasTX 75235USA

Nanotechnology-based drug delivery platforms have been developed over the last two decades because of their favorable features in terms of improved drug bioavailability and *** recent advancement in nanotechnology platforms,this approach still falls short to meet the complexity of biological systems and diseases,such as avoiding systemic side effects,manipulating biological interactions and overcoming drug resistance,which hinders the therapeutic outcomes of the NP-based drug delivery *** address these issues,various strategies have been developed including the use of engineered cells and/or cell membrane-coated *** membrane receptor profiles and characteristics are vital in performing therapeutic functions,targeting,and homing of either engineered cells or cell membrane-coated nanocarriers to the sites of *** this context,we comprehensively discuss various cell-and cell membrane-based drug delivery approaches towards cancer therapy,the therapeutic potential of these strategies,and the limitations associated with engineered cells as drug carriers and cell membrane-associated drug ***,we review various cell types and cell membrane receptors for their potential in targeting,immunomodulation and overcoming drug resistance in cancer.

关键词： Cell membrane-based drug delivery cell-mediated drug delivery membrane receptors drug carriers cancer drug resistance nanoparticles

Wnt/b-catenin signaling plays an ever-expanding role in stem cell self-renewal,tumorigenesis and cancer chemoresistance

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Genes & Diseases 2016年第1期3卷 11-40页

作者： Maryam K.Mohammed Connie Shao Jing Wang Qiang Wei Xin Wang Zachary Collier Shengli Tang Hao Liu Fugui Zhang Jiayi Huang Dan Guo Minpeng Lu Feng Liu Jianxiang Liu Chao Ma Lewis L.Shi Aravind Athiviraham Tong-Chuan He Michael J.Lee The University of Chicago Pritzker School of Medicine ChicagoIL 60637USA Molecular Oncology Laboratory Department of Orthopaedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Ministry of Education Key Laboratory of Diagnostic Medicine and the Affiliated Hospitals of Chongqing Medical UniversityChongqing 400016China Department of Surgery West China Hospital of Sichuan UniversityChengdu 610041China Departments of General Surgery and Neurosurgerythe Affiliated Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Orthopaedic Surgery Union Hospital of Tongji Medical CollegeHuazhong University of Science&TechnologyWuhan 430022China

Wnt signaling transduces evolutionarily conserved pathways which play important roles in initiating and regulating a diverse range of cellular activities,including cell proliferation,calcium homeostasis,and cell *** role of Wnt signaling in controlling cell proliferation and stem cell self-renewal is primarily carried out through the canonical pathway,which is the best-characterized the multiple Wnt signaling *** past 10 years has seen a rapid expansion in our understanding of the complexity of this pathway,as many new components of Wnt signaling have been identified and linked to signaling regulation,stem cell functions,and adult tissue ***,a substantial body of evidence links Wnt signaling to tumorigenesis of cancer types and implicates it in the development of cancer drug ***,a better understanding of the mechanisms by which dysregulation of Wnt signaling precedes the development and progression of human cancer may hasten the development of pathway inhibitors to augment current *** review summarizes and synthesizes our current knowledge of the canonical Wnt pathway in development and *** begin with an overview of the components of the canonical Wnt signaling pathway and delve into the role this pathway has been shown to play in stemness,tumorigenesis,and cancer drug ***,we hope to present an organized collection of evidence implicating Wnt signaling in tumorigenesis and chemoresistance to facilitate the pursuit of Wnt pathway modulators that may improve outcomes of cancers in which Wnt signaling contributes to aggressive disease and/or treatment resistance.

关键词： cancer drug resistance cancer stem cells Canonical Wnt b-Catenin Wnt