Exploring near-infrared absorbing nanocarriers to overcome cancer drug resistance
作者机构：Department of PhysiologyFaculty of MedicineMcGill UniversityMontreal H3G1Y6QuebecCanada.
出 版 物：《Cancer Drug Resistance》 (癌症耐药（英文）)
年 卷 期：2020年第3卷第3期
页 面：302-333页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Natural Sciences and Engineering Research Council of Canada, NSERC Mitacs
主 题：Cancer drug resistance chemotherapy nanomedicine near-infrared light combination therapy photothermal therapy photodynamic therapy controlled drug release
摘 要：One of the major obstacles of successful cancer therapy is cancer drug *** unique tools and applications developed by nanomedicine provide new approaches to surmount this common limitation of current treatment *** that absorb light in the near-infrared spectrum are particularly suitable for this *** nanocarriers can produce heat,release drugs or stimulate the production of physiologically relevant compounds when illuminated with near-infrared *** current review summarizes the causes contributing to cancer multidrug *** major types of nanocarriers that have been developed in recent years to overcome these hurdles are *** focus on nanoparticles that are responsive to near-infrared light and suitable to surmount cancer multidrug *** review concludes with the bottlenecks that currently restrict the use of nanocarriers in the clinic and an outlook on future directions.
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