The importance of epithelial-mesenchymal transition and autophagy in cancer drug resistance
作者机构:School of Biological SciencesFaculty of Environmental and Life SciencesUniversity of SouthamptonSouthampton SO171BJUK Institute for Life SciencesUniversity of SouthamptonSouthampton SO171BJUK
出 版 物:《Cancer Drug Resistance》 (癌症耐药(英文))
年 卷 期:2020年第3卷第1期
页 面:38-47页
学科分类:1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金:This project was supported by an Academy of Medical Sciences/the Wellcome Trust Springboard Award[SBF002\1038] Medical Research Council[MR/S025480/1] CH was supported by Gerald Kerkut Charitable Trust and University of Southampton Central VC Scholarship Scheme
主 题:Epithelial-mesenchymal transition autophagy cancer drug resistance metastasis therapy
摘 要:Epithelial-mesenchymal transition(EMT)and autophagy are both known to play important roles in the development of ***,these processes are now being utilised as targets for *** is globally one of the leading causes of death,and,despite many advances in treatment options,patients still face many *** resistance in cancer-therapy is a large problem,and both EMT and autophagy have been shown to ***,given the context-dependent role of these processes and the complexity of the interactions between them,elucidating how they both act alone and interact is *** this review,we provide insight into the current landscape of the interactions of autophagy and EMT in the context of malignancy,and how this ultimately may affect drug resistance in cancer therapy.