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Structural Aberrations of Cellular Sialic Acids and Their Functions in cancer Metastases

Journal of Shanghai University(English Edition) 2001年第2期5卷 164-170页

作者： LU Da yong, CAO Jing yi School of Life Sciences, Shanghai University, Shanghai 200436 School of Life Sciences Shanghai University Shanghai

Sialic acids (neuraminic acids) are a special series of 9 carbon ring negatively charged carbohydrates, which has been found to be selectively changed in malignant cells from structures (both synthesis and structure modifications) to functions (up and down regulation in cells). Sialic acids, in single forms or conjugates, have been systematically studied both in lab and in clinics by GC, GC MS, NMR, HPTLC, HPLC and other modern analytical means. Sialic acids and related conjugates are predicted to be used in cancer diagnosis, cancer prognostic forecasting, designing of cancer chemotherapy regimens, uncovering carcinogenetic processes and neoplasm metastasis. Tumor cell regulative systems and pathways are correlated with sialic acids, which can be applied to prognostic evaluation of cancer patients, and antimetastatic chemotherapy by sialic acid derivatives and analogues. Searching for new biological characteristics of sialic acids in cells have also been extensively studied these days. In this paper, main stream discoveries and advancements are provided , also discussions of possible mechanisms and hypotheses are invoked.

关键词： sialic acid neoplasm metastasis cancer diagnosis cancer pathology cancer chemotherapy

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Enzyme Dynamic Study on Calmodulin Ca^(++)-Mg^(++)-ATPase System of Red Blood Cells Inhibited byα-anordrin and Probimane

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Advances in Manufacturing 1998年第1期 84-86页

作者： Lu Dayong Chen Enhong Cao Jingyi Xu Bin School of Life Sciences Shanghai University Shanghai Institute of Materia Medica Chinese Academy of Sciences

To clarify the possible mechanisms of α anordin and probimane on calmodulin Ca ++ Mg ++ APTase system, enzyme dynamic study was carried out by determining three dynamic parameters [the substrate concentration(ATP) response curve, dose(inhibitors) response curve and time response curve]. Our data have shown that the inhibitory rates of α anordrin and probimane are unrelated to substrate(APT) concentrations, but related to calmodulin concentrations. The inhibition of α anordrin and probimane is very quick that is completed within 1 to 5 min and can maintain more than 1 hr in the same inhibitory rates. So it is possible that α anordrin and probimane are calmodulin competitors with calmodulin like binding whose actions can occur by affecting the reaction balance of substrate and product on target enzymes of calmodulin( Ca ++ Mg ++ ATPase).

关键词： antineoplastic agents calmodulin enzyme dynamics α anordrin probimane cell signal cancer pathology

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