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Decoupling the role of chemistry and microstructure in hMSCs response to an osteoinductive calcium phosphate ceramic

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Bioactive Materials 2023年第1期19卷 127-138页

作者： V.P.Galván-Chacon D.de Melo Pereira S.Vermeulen H.Yuan J.Li P.Habibovic MERLN Institute for Technology Inspired Regenerative Medicine Maastricht Universitythe Netherlands Kuros Biosciences BV 3723 MBBilthoventhe Netherlands

calcium phosphates(CaP)are widely used synthetic bone graft substitutes,having bioactivity that is regulated by a set of intertwined physico-chemical and structural properties.While some CaPs have shown to be as effective in regenerating large bone defects as autologous bone,there is still the need to understand the role of individual material properties in CaP performance.Here,we aimed to decouple the effects of chemical composition and surface-microstructure of a beta-tricalcium phosphate(TCP)ceramic,with proven osteoinductive potential,on human mesenchymal stromal cells(hMSCs)differentiation.To this end,we replicated the surface structure of the TCP ceramic into polylactic acid without inorganic additives,or containing the chemical constituents of the ceramic,i.e.,a calcium salt,a phosphate salt,or TCP powder.The microstructure of the different materials was characterized by confocal laser profilometry.hMSCs were cultured on the materials,and the expression of a set of osteogenic genes was determined.The cell culture medium was collected and the levels of calcium and phosphate ions were quantified by inductively-coupled plasma mass spectrometry.The results revealed that none of the tested combinations of properties in polymer/composite replicas was as potent in supporting the osteogenic differentiation of hMSCs as the original ceramic.Nevertheless,we observed some effects of the surface structure in the absence of inorganics,as well as combined effects of surface structure and the added salts,in particular calcium,on osteogenic differentiation.The approach presented here can be used to study the role of independent properties in other CaP-based biomaterials.

关键词： calcium phosphate Microstructure Chemical composition Mesenchymal stromal cells Osteogenic differentiation

Application of osteoinductive calcium phosphate ceramics in giant cell tumor of the sacrum:report of six cases

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Regenerative Biomaterials 2022年第1期9卷 156-162页

作者： Yitian Wang Xiangfeng Li Yi Luo Li Zhang Hezhong Chen Li Min Qing Chang Yong Zhou Chongqi Tu Xiangdong Zhu Xingdong Zhang Department of Orthopedics Orthopedics Research InstituteWest China HospitalSichuan UniversityChengdu 610041China Bone and Joint 3D-Printing&Biomechanical Laboratory Department of OrthopedicsWest China HospitalSichuan UniversityNo.37 GuoxuexiangChengdu 610041SichuanChina National Engineering Research Center for Biomaterials Sichuan UniversityChengdu 610064China Sichuan Baiameng Bioactive Materials Limited Liability Company No.37 GuoxuexiangChengdu 610041SichuanChina

This study aimed at evaluating the possibility and effectiveness of osteoinductive bioceramics to fill the tumor cavity following the curettage of sacral giant cell tumor(GCT).Six patients(four females and two males,25–45 years old)underwent nervesparing surgery,in which the tumor was treated by denosumab,preoperative arterial embolization and extensive curettage.The remaining cavity was filled with commercial osteoinductive calcium phosphate(CaP)bioceramics,whose excellent osteoinductivity was confirmed by intramuscular implantation in beagle canine.All patients were followed by computed tomography(CT)scans postoperatively.According to the modified Neer criterion,five cases obtained Type I healing status,and one case had Type II.At the latest follow-up,no graft-related complications and local recurrence were found.The CT scan indicated a median time of healing initiation of 3months postoperatively,and the median time for relatively complete healing was 12months.The excellent bone regenerative ability of the ceramics was also confirmed by increased CT attenuation value,blurred boundary and cortical rim rebuilding.In conclusion,osteoinductive CaP bioceramics could be an ideal biomaterial to treat the large remaining cavity following extensive curettage of sacral GCT.However,further investigation with more cases and longer follow-up was required to confirm the final clinical effect.

关键词： calcium phosphate bioceramics giant cell tumor sacrum osteoinductivity

Biological calcium phosphate nanorods for piezocatalytical extraction of U(VI)from water

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Nano Research 2023年第11期16卷 12772-12780页

作者： Feixue Gao Zhe Wang Ming Fang Xiaoli Tan Shao Hui Xu Mao Liu Guang Tao Fei Li De Zhang MOE Key Laboratory of Resources and Environmental System Optimization College of Environmental Science and EngineeringNorth China Electric Power UniversityBeijing 102206China Key Laboratory of Materials Physics and Anhui Key Laboratory of Nanomaterials and Nanotechnology Institute of Solid State PhysicsHefei Institutes of Physical ScienceChinese Academy of SciencesP.O.Box 1129Hefei 230031China Key Laboratory of Salt Lake Resources and Chemistry Qinghai Institute of Salt LakesChinese Academy of SciencesXining 810008China

The application of nanomaterials in energy and environmental fields has recently made great progress.As a key element in the nuclear industry,the discharge of uranium(U(VI))contained wastewater usually induces environmental issues and waste of resources.Although the catalytically generated H_(2)O_(2)by nanomaterials has recently shown application potential in extracting U(VI)from water,low-cost and highly efficient nanocatalysts are still urgently needed.In this work,a cheap and readily available piezocatalyst of calcium phosphate nanorods was successfully fabricated by calcining chicken bones.Under ultrasonication,H_(2)O_(2)was produced and used to extract U(VI)from water.It is worth noting that the yield of H_(2)O_(2)reached 179.7μmol·g^(−1)·h^(−1),and the extraction efficiency of U(VI)in water reached 97.16%(100 ppm)within 330 min.Through the capture and quantitative analysis of the active species,it is found that the generation of H_(2)O_(2)depends on the combination of soluble oxygen and piezoelectrons,which thus dominates the extraction of U(VI).This simple and powerful piezocatalytic strategy greatly reduces the cost of H_(2)O_(2)production for U(VI)extraction in water,and is of great significance for the treatment of U(VI)-containing wastewater.

关键词： nanorods uranium piezocatalysis calcium phosphate H2O2

calcium phosphate Scaffolds Combined with Bone Morphogenetic Proteins or Mesenchymal Stem Cells in Bone Tissue Engineering

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Chinese Medical Journal 2015年第8期128卷 1121-1127页

作者： Han Sun Hui-Lin Yang Department of Orthopedics First Affiliated Hospital of Soochow University Jiangsu 215006 China

Objective： The purpose of this study was to review the current status of calcium phosphate （CAP） scaffolds combined with bone morphogenetic proteins （BMPs） or mesenchymal stem cells （MSCs） in the field of bone tissue engineering （BTE）. Date Sources： Data cited in this review were obtained primarily from PubMed and Medline in publications from 1979 to 2014, with highly regarded older publications also included. The terms BTE, CaE BMPs, and MSC were used for the literature search. Study Selection： Reviews focused on relevant aspects and original articles reporting in vitro and/or in vivo results concerning the efficiency of CaP/BMPs or CaP/MSCs composites were retrieved, reviewed, analyzed, and summarized. Results： An ideal BTE product contains three elements： Scaffold, growth factors, and stem cells. CaP-based scaffolds are popular because of their outstanding biocompatibility, bioactivity, and osteoconductivity. However, they lack stiffness and osteoinductivity. To solve this problem, composite scaffolds of CaP with BMPs have been developed. New bone formation by CaP/BMP composites can reach levels similar to those of autografts. CaP scaffolds are compatible with MSCs and CaP/MSC composites exhibit excellent osteogenesis and stiffness. In addition, a CaP/MSC/BMP scaffold can repair bone defects more effectively than an autograft. Conclusions： Novel BTE products possess remarkable osteoconduction and osteoinduction capacities, and exhibit balanced degradation with osteogenesis. Further work should yield safe, viable, and efficient materials for the repair of bone lesions.

关键词： Bone Morphogenetic Proteins calcium phosphate Mesenchymal Stem Cells Tissue Engineering

calcium phosphate coatings enhance biocompatibility and degradation resistance of magnesium alloy:Correlating in vitro and in vivo studies

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Bioactive Materials 2021年第5期6卷 1223-1229页

作者： Julia Gao Yingchao Su Yi-Xian Qin Department of Biomedical Engineering Stony Brook UniversityStony BrookNY11794United States

Magnesium(Mg)and its alloys are promising biodegradable materials for orthopedic applications.However,one of the major problems is their rapid degradation rate with quick evolution of hydrogen gas.To overcome this problem,calcium phosphate(CaP)coatings have been used to improve the degradation resistance and the biocompatibility of Mg materials.This study focuses on the comparison and correlation of the in vitro and in vivo degradation and biocompatibility behaviors of these materials.A CaP coating consisting of dicalcium phosphate dihydrate(DCPD)was deposited on an AZ60 Mg alloy by the chemical conversion method.Then,the in vitro degradation testing including electrochemical and immersion tests,and in vivo implantation of the CaP coated Mg alloy were conducted to compare the degradation behaviors.Next,the in vitro cell behavior and in vivo bone tissue response were also compared on both uncoated and CaP-coated Mg samples.Data showed that the CaP coating provided the Mg alloy with significantly better biodegradation behavior and biocompatibility.The in vitro and in vivo biocompatibility tests exhibited good consistency while not the case for biodegradation.Results showed that the in vitro electrochemical test could be a quick screening tool for the biodegradation rate,while the in vitro immersion degradation rate was often 2-4 folds faster than the in vivo degradation rate.

关键词： Magnesium implants calcium phosphate Biodegradation Cytocompatibility Bone regeneration

Effect of minor amounts of β-calcium pyrophosphate and hydroxyapatite on the physico-chemical properties and osteoclastic resorption of β-tricalcium phosphate cylinders

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Bioactive Materials 2022年第4期7卷 222-235页

作者： B.Le Gars Santoni L.Niggli S.Dolder O.Loeffel G.A.Sblendorio R.Heuberger RMS Foundation Bioceramics and Biocompatibility GroupBischmattstrasse 12CH-2544BettlachSwitzerland University of Bern Graduate School for Cellular and Biomedical SciencesMittelstrasse 43CH-3012BernSwitzerland University of Bern Department for BioMedical Research(DBMR)Murtenstrasse 35CH-3008BernSwitzerland RMS Foundation Materials GroupBischmattstrasse 12CH-2544BettlachSwitzerland EPFL Ecole Polytechnique Federale de LausanneConstruction Materials LaboratoryStation 12CH-1015LausanneSwitzerland

β-Tricalcium phosphate(β-TCP),one of the most used bone graft substitutes,may contain up to 5 wt%foreign phase according to standards.Typical foreign phases includeβ-calcium pyrophosphate(β-CPP)and hydroxyapatite(HA).Currently,the effect of small amounts of impurities on β-TCP resorption is unknown.This is surprising since pyrophosphate is a very potent osteoclast inhibitor.The main aim of this study was to assess the effect of small β-CPP fractions(<1 wt%)on the in vitro osteoclastic resorption of β-TCP.A minor aim was to examine the effect of β-CPP and HA impurities on the physico-chemical properties of β-TCP powders and sintered cylinders.Twenty-six batches of β-TCP powder were produced with a Ca/P molar ratio varying between 1.440 and 1.550.Fifteen were further processed to obtain dense and polished β-TCP cylinders.Finally,six of them,with a Ca/P molar ratio varying between 1.496(1 wt% β-CPP)and 1.502(1 wt% HA),were incubated in the presence of osteoclasts.Resorption was quantified by white-light interferometry.Osteoclastic resorption was significantly inhibited by β-CPP fraction in a linear manner.The presence of 1% β-CPP reduced β-TCP resorption by 40%,which underlines the importance of controllingβ-CPP content when assessing β-TCP biological performance.

关键词： Bioceramics calcium phosphate β-Tricalcium phosphate β-calcium pyrophosphate Hydroxyapatite Osteoclastic resorption

Effect of humic substances on the precipitation of calcium phosphate

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Journal of Environmental Sciences 2006年第5期18卷 852-857页

作者： SONG Yong-hui Hermann H. HAHN Erhard HOFFMANN Peter G. WEIDLER Chinese Research Academy of Environmental Sciences Beijing 100012 China Institute for Aquatic Environmental Engineering University of Karlsruhe Karlsruhe D-76128 Germaay Institute for Technical Chemistry Research Centre of Karlsruhe Eggenstein-Leopoldshafen D-76344 Germany

For phosphorus （P） recovery from wastewater, the effect of humic substances （HS） on the precipitation of calcium phosphate was studied. Batch experiments of calcium phosphate precipitation were undertaken with synthetic water that contained 20 mg/L phosphate （as P） and 20 mg/L HS （as dissolved organic carbon, DOC） at a constant pH value in the range of 8.0-10.0. The concentration variations of phosphate, calcium （Ca） and HS were measured in the precipitation process; the crystalline state and compositions of the precipitates were analysed by powder X-ray diffraction （XRD） and chemical methods, respectively. It showed that at solution pH 8.0, the precipitation rate and removal efficiency of phosphate were greatly reduced by HS, but at solution pH ≥9.0, the effect of HS was very small. The Ca consumption for the precipitation of phosphate increased when HS was added; HS was also removed from solution with the precipitation of calcium phosphate. At solution pH 8.0 and HS concentrations ≤3.5 mg/L, and at pH ≥ 9.0 and HS concentrations ≤ 10 mg/L, the final precipitates were proved to be hydroxyapatite （HAP） by XRD. The increases of solution pH value and initial Ca/P ratio helped reduce the influence of HS on the precipitation of phosphate.

关键词： calcium phosphate phosphorus recovery precipitation humic substances initial CaJP ratio solution pH value

Facile Approach to Synthesize Gold Nanorod@Polyacrylic Acid/calcium phosphate Yolk–Shell Nanoparticles for Dual-Mode Imaging and pH/NIR-Responsive Drug Delivery

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Nano-Micro Letters 2018年第1期10卷 63-73页

作者： Guilan Li Yidan Chen Lingyu Zhang Manjie Zhang Shengnan Li Lu Li Tingting Wang Chungang Wang Faculty of Chemistry Northeast Normal University School of Chemistry and Environmental Engineering Changchun University of Science and Technology

A facile strategy to fabricate gold nanorod@polyacrylic acid/calcium phosphate(Au NR@-PAA/Ca P) yolk–shell nanoparticles(NPs) composed with a PAA/Ca P shell and an Au NR yolk is reported. The asobtained Au NR@PAA/Ca P yolk–shell NPs possess ultrahigh doxorubicin(DOX) loading capability(1 mg DOX/mg NPs), superior photothermal conversion property(26%)and p H/near-infrared(NIR) dual-responsive drug delivery performance. The released DOX continuously increased due to the damage of the Ca P shell at low p H values. When the DOX-loaded Au NR@PAA/Ca P yolk–shell NPs wereexposed to NIR irradiation, a burst-like drug release occurs owing to the heat produced by the Au NRs. Furthermore,Au NR@PAA/Ca P yolk–shell NPs are successfully employed for synergic dual-mode X-ray computed tomography/photoacoustic imaging and chemo-photothermal cancer therapy. Therefore, this work brings new insights for the synthesis of multifunctional nanomaterials and extends theranostic applications.

关键词： Yolk–shell structure calcium phosphate Dual-mode imaging Photothermal therapy Drug delivery

Comparative investigations of structure and properties of micro-arc wollastonite-calcium phosphate coatings on titanium and zirconiumniobium alloy

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Bioactive Materials 2017年第3期2卷 177-184页

作者： M.B.Sedelnikova E.G.Komarova Yu.P.Sharkeev T.V.Tolkacheva I.A.Khlusov L.S.Litvinova K.A.Yurova V.V.Shupletsova Institute of Strength Physics and Materials Science of SB RAS Academicheskii pr.2/4634055TomskRussia National Research Tomsk Polytechnic University Lenina pr.30634050TomskRussia Siberian State Medical University 2 Moskovsky tr.634050TomskRussia Immanuel Kant Baltic Federal University 14 A.Nevskogo st.236041KaliningradRussia

Investigation results of micro-arc wollastoniteecalcium phosphate(W-CaP)biocoatings on the pure titanium(Ti)and Zr-1wt.%Nb(Zr-1Nb)alloy were presented.The voltages of 150-300 V generate the micro-arc oxidation(MAO)process with the initial amplitude current of 150-550 A and 100-350 A for Ti and Zr-1Nb substrates,respectively.The identical dependencies of changes of the coating thickness,surface roughness and adhesion strength on the process voltage were revealed for the both substrates.The W-CaP coatings with the thickness of 10-11μm were formed on Ti and Zr-1Nb under the low process voltage of 130-150 V.Elongated wollastonite particles with the size in the range of 40-100μm were observed in such coatings.The structure of the coatings on Ti was presented by the X-ray amorphous and crystalline phases.The X-ray reflexes relating to the crystalline phases of Ti and wollastonite were observed only in XRD patterns of the coatings deposited under 130-200 V on Ti.While,the crystalline structure with phases of CaZr4(PO4)6,β-ZrP2O7,ZrO2,and Zr was detected in the coatings on Zr-1Nb.FT-IRS,XRD,SEM,and TEM data confirmed that the increase of the process voltage to 300 V leads to the dissociation of the wollastonite.No toxic effect of specimens on a viability,morphology and motility of human adipose-derived multipotent mesenchymal stem cells was revealed in vitro.

关键词： Micro-arc oxidation Biocoatings calcium phosphate Wollastonite