Calcium phosphate coatings enhance biocompatibility and degradation resistance of magnesium alloy:Correlating in vitro and in vivo studies
作者机构：Department of Biomedical EngineeringStony Brook UniversityStony BrookNY11794United States
出 版 物：《Bioactive Materials》 (生物活性材料（英文）)
年 卷 期：2021年第6卷第5期
页 面：1223-1229页
核心收录：
学科分类：08[工学] 080502[工学-材料学] 0805[工学-材料科学与工程（可授工学、理学学位）]
主 题：Magnesium implants Calcium phosphate Biodegradation Cytocompatibility Bone regeneration
摘 要：Magnesium(Mg)and its alloys are promising biodegradable materials for orthopedic ***,one of the major problems is their rapid degradation rate with quick evolution of hydrogen *** overcome this problem,calcium phosphate(CaP)coatings have been used to improve the degradation resistance and the biocompatibility of Mg *** study focuses on the comparison and correlation of the in vitro and in vivo degradation and biocompatibility behaviors of these materials.A CaP coating consisting of dicalcium phosphate dihydrate(DCPD)was deposited on an AZ60 Mg alloy by the chemical conversion ***,the in vitro degradation testing including electrochemical and immersion tests,and in vivo implantation of the CaP coated Mg alloy were conducted to compare the degradation ***,the in vitro cell behavior and in vivo bone tissue response were also compared on both uncoated and CaP-coated Mg *** showed that the CaP coating provided the Mg alloy with significantly better biodegradation behavior and *** in vitro and in vivo biocompatibility tests exhibited good consistency while not the case for *** showed that the in vitro electrochemical test could be a quick screening tool for the biodegradation rate,while the in vitro immersion degradation rate was often 2-4 folds faster than the in vivo degradation rate.
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