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Imaging diagnosis of bronchogenic carcinoma(the forgotten disease)during times of COVID-19 pandemic:Current and future perspectives

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World Journal of Clinical Oncology 2021年第6期12卷 437-457页

作者： Ravikanth Reddy Department of Radiology St.John's HospitalBengaluru 560034KarnatakaIndia

Patients with bronchogenic carcinoma comprise a high-risk group for coronavirus disease 2019(COVID-19),pneumonia and related *** of COVID-19 related pulmonary syndrome may be similar to deteriorating symptoms encountered during bronchogenic carcinoma *** resemblances add further complexity for imaging assessment of bronchogenic *** between clinical and imaging findings can pose a major challenge to clinicians in distinguishing COVID-19 super-infection from evolving bronchogenic carcinoma,as the above-mentioned entities require very different therapeutic ***,the goal of bronchogenic carcinoma management during the pandemic is to minimize the risk of exposing patients to COVID-19,whilst still managing all life-threatening events related to bronchogenic *** current pandemic has forced all healthcare stakeholders to prioritize per value resources and reorganize therapeutic strategies for timely management of patients with COVID-19 related pulmonary *** of radiographic and computed tomography images by means of artificial intelligence techniques can facilitate triage of *** and newer therapeutic strategies for patients with bronchogenic carcinoma have been adopted by oncologists around the world for providing uncompromised care within the accepted standards and new guidelines.

关键词： COVID-19 bronchogenic carcinoma Immune checkpoint inhibitor-related pneumonitis Prioritizing imaging Surveillance of lung nodules Artificial intelligence

Study of serum level of sex hormones and expression of their receptors in patients with bronchogenic carcinoma

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Journal of Medical Colleges of PLA(China) 2004年第2期19卷 131-134页

作者：陈明伟张玉健李忠民 Respiratory Department First Hospital of Xi'an JiaoTong University Xi'an 710061 China Jiaotong Hospital of Shaanxi Xi'an 710068 China

Objective: To study the serum level of estradiol, progesterone and testosterone (SEL, SPL and STL) and the expression of the receptors of estradiol and progesterone (ER and PR) in 53 cases of bronchogenic carcinoma. Methods: ER and PR in the tissue of the carcinoma were determined with enzyme-linked affinity histochemical method. SEL, SPL and STL were measured with double antibody radioimmunoassay. Results: Most of ER and PR were present in the cytoplasm of the malignant cells (58.2%) and the positive rates of ER and PR were 49.1% and 54.7% respectively. SEL and SPL were significantly higher in the patients with lung cancer than in the subjects of the control groups (Pbronchogenic carcinoma indicates that the pathogenesis of bronchogenic carcinoma is sex hormone dependent to some extent. ER and SEL are negatively correlated with a correlative coefficient of -1.

关键词： bronchogenic carcinoma sex hormone receptor

Assessing no-surgical treatment response in bronchogenic carcinoma with contrast material-enhanced computed tomography

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The Chinese-German Journal of Clinical Oncology 2010年第5期9卷 262-265页

作者： Shenjiang Li Feng Zhu Yan Zhu Debin Liu Wenjie Liang Xuefeng Cui Wenjie Bi Department of Imageology The Eighty-eighth Military Hospital Tai＇an 271000 China

Objective:The aim of the study was to evaluate the efficacy of contrast material-enhanced computed tomography(CT) in assessing no-surgical treatment response in bronchogenic ***:The 67 patients with bronchogenic carcinoma after no-surgical treatment underwent two-phase contrast material-enhanced computed *** spiral CT scans were obtained at 25 and 90 s respectively after nonionic contrast material was administrated via the antecubital vein at a rate of 4 mL/s by using an *** and postcontrast attenuation values on every scan were recorded and peak height was *** pattern was evaluated on the image obtained at 25 and 90 s after injection of contrast ***:Precontrast attenuation value,postcontrast attenuation values at 25 and 90 s were(41.26 ± 7.77) Hu,(56.45 ± 10.48) Hu,(70.82 ± 11.99) Hu,*** statistically significant difference in precontrast attenuation was found between our results in this study and the results in our old study(mean precontrast attenuation 40.70 Hu) which was obtained in cases without any therapy(t = 0.593,P = 0.555﹥0.05).Peak height of bronchogenic carcinoma after no-surgical treatment [(29.40 ± 10.73) Hu] were significantly lower than that of bronchogenic carcinoma without any therapy obtained in our old study(mean peak height 35.79 Hu)(t =-4.874,P = 0.001 bronchogenic carcinoma and might be an index for evaluation of no-surgical treatment response in bronchogenic carcinoma.

关键词： bronchogenic carcinoma tomography X-ray computed image enhancement evaluation of curative effect

Preliminary assessing no-surgical treatment response in bronchogenic carcinoma with three-phase contrast material-enhanced MRI

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The Chinese-German Journal of Clinical Oncology 2010年第8期9卷 444-447页

作者： Shenjiang Li Xuefeng Cui Debin Liu Wenjie Liang Yan Zhu Wenjie Bi Department of Imageology The Eighty-eighth Military Hospital Tai＇an 271000 China

Objective:The aim of this study was to evaluate the efficacy of three-phase contrast material-enhanced MRI in assessing no-surgical treatment response in peripheral bronchogenic carcinoma ***:Twenty-two patients with bronchogenic carcinoma after no-surgical treatment underwent three-phase contrast material-enhanced *** scans were obtained at 25 s,120 s and 180 s respectively after nonionic contrast material was administrated via the antecubital vein at a rate of 2 mL/s by using an *** and postcontrast signal intensity on every scan was *** Height(PH) and Maximum Enhancement(Emax) were *** pattern was evaluated on the images obtained at 120 s and 180 s after injection of contrast ***:Precontrast signal intensity,postcontrast signal intensity at 120 s and 180 s were 478 ± 108,926 ± 209 and 1050 ± ***(571 ± 225) and Emax(119 ± 49) of bronchogenic carcinoma after no-surgical treatment were significantly lower than those of bronchogenic carcinoma without any therapy(mean PH 655,mean Emax 150)(t = 2.178,P = 0.005 bronchogenic carcinoma after no-surgical treatment shows a gradual increase to the PH after administration of contrast ***-phase contrast material-enhanced MRI can reflect the blood supply of bronchogenic carcinoma and might be effective approach for evaluation of no-surgical treatment response in bronchogenic carcinoma.

关键词： bronchogenic carcinoma MRI image enhancement evaluation of curative effect

Preliminary assessing no-surgical treatment response in bronchogenic carcinoma with double-phase contrast material-enhanced computed tomography

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The Chinese-German Journal of Clinical Oncology 2009年第7期8卷 152-155页

作者： Shenjiang Li Yong Zhao Yan Zhu Feng Zhu Debin Liu Wenjie Liang Xuefeng Cui Wenjie Bi Department of Imageology The Eighty-eighth Military Hospital Tai＇an 271000 China

Objective： To evaluate the efficacy of double-phase contrast material-enhanced computed tomography （CT） in assessing no-surgical treatment response in bronchogenic carcinoma preliminarily. Methods： 52 patients with bronchogenic carcinoma after no-surgical treatment underwent double-phase contrast material-enhanced computed tomography. Two spiral CT scans were obtained at 25 and 90 seconds respectively after nonionic contrast material was administrated via the antecubital vein at a rate of 4 mUs by using an autoinjector. Precontrast and postcontrast attenuation on every scan was recorded and peak height was calculated. Enhancement pattern was evaluated on the images obtained at 25 and 90 seconds after injection of contrast medium. Results： Precontrast attenuation, postcontrast attenuation at 25 and 90 seconds were 42.20 ± 7.43 Hu, 57.35 ± 10.09 Hu and 71.85 ±12.45 Hu, respectively. No statistically significant difference in precontrast attenuation was found between our results in the study and the results in our old study （mean precontrast attenuation 40.70 Hu） which was obtained in cases before therapy （t = 1.455, P = 0.152 〉 0.05）. Peak height of bronchogenic carcinoma after no-surgical treatment （29.46 ±10.85 Hu） were significantly lower than that of bronchogenic carcinoma before therapy obtained in our old study （mean peak height 35.79 Hu; t = 4.206, P = 0.001 〈 0.05）. 32 of 52 cases showed homogeneous enhancement at 90 seconds. Of the 32 cases, there were 21 with inhomogeneous enhancement, 7 with inhomogeneous enhancement, 2 with central enhancement and 2 with peripheral enhancement at 25 seconds. Conclusion： bronchogenic carcinoma after no-surgical treatment shows a gradual increase to the peak height after administration of contrast material. Peak heights can reflect the blood supply of bronchogenic carcinoma and might be index for evaluation of no-surgical treatment response in bronchogenic carcinoma.

关键词： bronchogenic carcinoma tomography, X-ray computed evaluation of therapeutic effect

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