检索结果-南通市图书馆

Chinese Journal of Integrative Medicine 2024年第4期30卷 379-384页

作者： XIN Li TAN Guo-yao ZHANG Qiang ZHANG Qun Good Clinical Practice Development Guangdong Provincial Key Laboratory of Bone and Joint Degeneration DiseasesThe Third Affiliated Hospital of Southern Medical UniversityGuangzhou(510630)China Department of Pharmacy Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou(510120)China

Phellodendron(PN)species,traditionally used in Chinese medicine for centuries,hold promise as a potential treatment for osteoporosis(OP)and osteoarthritis(OA)due to their bioactive *** bioactive compounds,including berberine and palmatine,exhibit anti-inflammatory,antioxidant,and bone-protective properties,contributing to their potential therapeutic benefits in promoting bone health and preventing bone ***,challenges such as the need for standardized preparation and dosing,limited clinical studies,and potential interactions with other medications hinder their clinical ***,the rich history of PN species in Chinese medicine provides a promising foundation for future investigation into their potential as alternative treatments for OP and *** research is needed to fully understand the underlying mechanisms of action and explore the clinical implications of PN for bone health.

关键词： Phellodendron species bone health osteoporosis osteoarthritis review

Clinical practice guidelines for full-cycle standardized management of bone health in breast cancer patients

在线全文

学校读者我要写书评

暂无评论

Cancer Innovation 2024年第1期3卷 1-28页

作者： Committee of Full-cycle Standardized Management of bone health in Breast Cancer Patients Fei Ma 不详 Department of Medical Oncology National Cancer CenterNational Clinical Research Center for CancerCancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

bone health management for breast cancer spans the entire cycle of patient care,including the prevention and treatment of bone loss caused by early breast cancer treatment,the adjuvant application of bone-modifying agents to improve prognosis,and the diagnosis and treatment of advanced bone *** good bone health management means formulating appropriate treatment strategies and dealing with adverse drug reactions,and will help to improve patients'quality of life and survival *** Breast Cancer Expert Committee of the National Cancer Center for Quality Control organized relevant experts to conduct an in-depth discussion on the full-cycle management of breast cancer bone health based on evidence-based medicine,and put forward reasonable suggestions to guide clinicians to better deal with health issues in bone health clinics.

关键词： bone health bone-modifying drugs breast cancer guidelines

bone health in Pediatric Fracture Patients: A DEXA Study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Orthopedics 2022年第2期12卷 57-65页

作者： Barbara Minkowitz Jennifer Ristic Leah Nadel Meghan McDermott Violet Wallerstein Eileen Poletick Department of Orthopedics Morristown Medical Center Goryeb Children’s Hospital Atlantic Health Systems Morristown NJ USA

Vitamin D deficiency is widespread in children and is associated with increased fracture severity. Previous studies have shown mixed results on the impact of vitamin D supplementation on bone health parameters measured on dual-energy x-ray absorptiometry (DEXA) scan. This is the first longitudinal DEXA study in a pediatric fracture population. Pediatric fracture patients with vitamin D levels below 20 ng/mL were counseled to take vitamin D and calcium per a serum-based protocol. Patients underwent baseline DEXA within the initial 12 weeks post fracture and had follow-up scans at 6 and 12 months. 48 patients were enrolled, 32 patients completed two DEXA scans, and 19 completed three DEXA scans. There was a significant increase in lumbar spine BMC, TBLH BMD, and TBLH BMC between DEXA 1 and 2 (p 0.001). A positive trend in DEXA parameters is suggested between DEXA 1 and DEXA 3. Height adjusted z-scores (HAZ) were calculated which showed no statistical significance, p-values > 0.05. In this group, there are no significant changes in TBLH, BMC or BMD z-scores one year after fracturing despite vitamin D and calcium supplementation. This suggests that children returning to collision sports may be at continued risk for refracture and future studies are needed.

关键词： bone health Pediatric Fracture Vitamin D DEXA Osteoporosis Osteopenia Vitamin D Deficiency

Combined effects of physical activity and calcium on bone health in children and adolescents:a systematic review of randomized controlled trials

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2020年第4期16卷 356-365页

作者： Xi Yang Yi Zhai Jian Zhang Jing-Yi Chen Dan Liu Wen-Hua Zhao National Institution for Nutrition and health Chinese Center for Disease Control and Prevention27 Nanwei RoadWest DistrictBeijingChina Department of Science and Technology Management Chinese Center for Disease Control and Prevention155 Changbai RoadChangping DistrictBeijingChina China National Clinical Research Center for Neurological Diseases Capital Medical UniversityNo.119 South Fourth Ring West RoadFengtai DistrictBeijingChina

Background A better understanding of the role of exercise and nutrition in bone health is significant for preventing *** aim of this review was to assess the combined effects of physical activity and calcium intake on improving bone mineral density in children and *** A search of electronic databases(MedLine,ISI Web of Science,Science Direct)and the literature references were *** controlled trials published between 1997 and 2017,evaluating the effect of both physical activity and calcium intake intervention on bone mineral density or bone mineral content among children aged 3–18 years were *** Improved Jadad Rating Scale was used to assess the methodological quality of the included *** characteristics were summarized in accordance with the review’s PICO *** in bone mineral content were detected at several different bone *** A total of nine studies involving 908 participants were included in this *** combined intervention of physical activity and calcium increased bone mineral in children and adolescents,especially when baseline calcium intake level was low and among participants on the stage of early *** Regular physical activity combined with high level of calcium intake is beneficial for bone health in young *** research is needed to evaluate the dose–response associations and long-term effects of the interaction between physical activity and calcium intake.

关键词： Adolescents bone health Calcium Children Physical activity

Calcium deficiency： where does the diagnostic criterion come from and by what is bone health influenced？

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2014年第24期127卷 4161-4163页

作者： Fang Aiping Li Keji Department of Nutrition and Food Hygiene Peking University Health Science Center Beijing 100191 China

Dietary surveys suggest that a considerable proportion of the population fail to consume recommended amounts of calcium m both developing and developed countries. Recommended allowance for dietary calcium has attracted many controversies and there are discrepant opinions on how to meet the recommendations in the global scientific community.

关键词： calcium deficiency diagnostic criterion calcium supplementation bone health recommended dietary allowances

Muscle strength deficits are associated with low bone mineral density in young pediatric cancer survivors:The iboneFIT project

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Sport and health Science 2024年第3期13卷 419-427页

作者： Andres Marmol-Perez Jose J.Gil-Cosano Esther Ubago-Guisado Francisco J.Llorente-Cantarero Juan Francisco Pascual-Gázquez Kirsten K.Ness Vicente Martinez-Vizcaino Jonatan R.Ruiz Luis Gracia-Marco Department of Physical Education and Sports Faculty of Sport SciencesSport and Health University Research Institute(iMUDS)University of GranadaGranada 18011Spain Department of Epidemiology and Cancer Control St.Jude Children's Research HospitalMemphisTN 38105USA Department of Communication and Education Loyola University AndalusiaSeville 41704Spain Biosanitary Research Institute ibs.GranadaGranada 18012Spain Maimonides Biomedical Research Institute of Cordoba(IMIBIC) Cordoba 14004Spain CIBEROBN Biomedical Research Networking Center for Physiopathology of Obesity and NutritionCarlos III Health InstituteMadrid 28029Spain Department of Specific Didactics Faculty of EducationUniversity of CordobaCordoba 14071Spain Pediatric and adolescent hematology and oncology service Pediatrics and Pediatric Surgery Clinical Management UnitVirgen de las Nieves University HospitalGranada 18014Spain health and Social Research Center Universidad de Castilla-La ManchaCuenca 13001Spain

Background Pediatric cancer survivors are at increased risk of muscle weakness and low areal bone mineral density(aBMD).However,the prevalence of muscle strength deficits is not well documented,and the associations of muscle strength with aBMD are unknown in this ***,this study aimed to investigate the prevalence of upper-and lower-body muscle strength deficits and to examine the associations of upper-and lower-body muscle strength with age-,sex,and race-specific aBMD Z-scores at the total body,total hip,femoral neck,and lumbar *** This cross-sectional study included 116 pediatric cancer survivors(12.1±3.3 years old,mean±SD;42.2%female).Upper-and lower-body muscle strength were assessed by handgrip and standing long jump test,***‑energy X‑ray absorptiometry was used to measure aBMD(g/cm2).Associations between muscle strength and aBMD were evaluated in multivariable linear regression *** regression was used to evaluate the contribution of muscle strength(1-decile lower)to the odds of having low aBMD(Z-score≤1.0).All analyses were adjusted for time from treatment completion,radiotherapy exposure,and body mass *** More than one-half of survivors were within the 2 lowest deciles for upper-(56.9%)and lower-body muscle strength(60.0%)in comparison to age-and sex-specific reference *** strength deficits were associated with lower aBMD Z-scores at all sites(B=0.133–0.258,p=0.001–0.032).Each 1-decile lower in upper-body muscle strength was associated with 30%–95%higher odds of having low aBMD Z-scores at all *** 1-decile lower in lower-body muscle strength was associated with 35%–70%higher odds of having low aBMD Z-scores at total body,total hip,and femoral *** Muscle strength deficits are prevalent in young pediatric cancer survivors,and such deficits are associated with lower aBMD Z-scores at all *** results suggest that interventions designed to improve muscle strength in t

关键词： bone health Childhood cancer DXA Lean mass Resistance training

Targeting gut microbiota in osteoporosis:impact of the microbial based functional food ingredients

在线全文

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年第1期13卷 1-15页

作者： Pauline Duffuler Khushwant S.Bhullar Jianping Wu Department of Agricultural Food&Nutritional Science University of AlbertaEdmonton T6G 2P5Canada

Osteoporosis is the most common bone disorder,characterized by low bone mineral density and microarchitectural deterioration of the bone tissue,which increases the susceptibility to *** the past decade,emerging research findings reported the implication of gut microbiota on bone health and osteoporosis *** patients or individuals with a lower bone mineral density exhibit an alteration of the gut microbiota at several taxonomic *** reports demonstrate that gut microbiota regulates bone metabolism through the modulation of the gut function(mineral availability and absorption,gut integrity),the immune system,and the endocrine ***,based on the vital role of gut microbiota on bone health,it has emerged as a novel therapeutic target for the prevention of bone loss and the treatment of ***-based functional food ingredients,such as probiotics,prebiotics,synbiotics,and fermented foods,have been developed to alter the gut microbiota composition and function and thus,to provide benefits to the host bone *** promising initial results,microbial-based therapies are still under ***,additional animal studies and clinical trials are needed to understand the interactions between gut microbiota and bone metabolism before further applications.

关键词： Dysbiosis bone health Probiotic Prebiotic Fermented food Synbiotic

Effects of normobaric cyclic hypoxia exposure on mesenchymal stem-cell differentiation–pilot study on bone parameters in elderly

在线全文

学校读者我要写书评

暂无评论

World Journal of Stem Cells 2020年第12期12卷 1667-1690页

作者： Marta Camacho-Cardenosa JoséManuel Quesada-Gómez Alba Camacho-Cardenosa Alejo Leal GabrielDorado Bárbara Torrecillas-Baena Antonio Casado-Díaz Facultad Ciencias del Deporte Universidad De ExtremaduraCáceres 10003Spain CIBER De Fragilidad Y Envejecimiento Saludable(CIBERFES) Unidad De Gestión Clínica De Endocrinología Y NutriciónInstituto Maimónides De Investigación Biomédica De CórdobaHospital Universitario Reina SofíaCórdoba 14004Spain Servicio de Traumatología Hospital de CáceresCáceres 10004Spain Departamento Bioquímica y Biología Molecular Campus Rabanales C6-1-E17Campus de Excelencia Internacional Agroalimentario(ceiA3)Universidad de Córdoba-CIBERFES14071 CórdobaSpain

BACKGROUND Mesenchymal stem cells(MSC)of bone marrow are the progenitor of osteoblasts and *** tend to differentiate into adipocytes,instead of osteoblasts,with *** favors the loss of bone mass and development of *** induces hypoxia inducible factor 1αgene encoding transcription factor,which regulates the expression of genes related to energy metabolism and *** allows a better adaptation to low O2 *** hypoxia has negative effects on bone metabolism,favoring bone ***,surprisingly,cyclic hypoxia(CH),short times of hypoxia followed by long times in normoxia,can modulate MSC differentiation and improve bone health in *** To evaluate the CH effect on MSC differentiation,and whether it improves bone mineral density in *** MSC cultures were induced to differentiate into osteoblasts or adipocytes,in CH(3%O2 for 1,2 or 4 h,4 d a week).Extracellular-matrix mineralization and lipid-droplet formation were studied in MSC induced to differentiate into osteoblast or adipocytes,*** addition,gene expression of marker genes,for osteogenesis or adipogenesis,have been quantified by quantitative real time polymerase chain *** in vivo studies with elderly(>75 years old;n=10)were carried out in a hypoxia chamber,simulating an altitude of 2500 m above sea level,or in normoxia,for 18 wk(36 CH sessions of 16 min each).Percentages of fat mass and bone mineral density from whole body,trunk and right proximal femur(femoral,femoral neck and trochanter)were assessed,using dual-energy X-ray *** CH(4 h of hypoxic exposure)inhibited extracellular matrix mineralization and lipid-droplet formation in MSC induced to differentiate into osteoblasts or adipocytes,***,both parameters were not significantly affected by the other shorter hypoxia times *** longest periods of hypoxia downregulated the expression of genes related to extracellular matrix

关键词： Normobaric cyclic hypoxia Mesenchymal stem cells Cellular differentiation Osteoblasts Adipocytes bone health

MRI analysis and clinical significance of lower extremity muscle cross-sectional area after spinal cord injury

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2017年第5期12卷 714-722页

作者： Robert M.Lester Kori Johnson Refka E.Khalil Rehan Khan Ashraf S.Gorgey Spinal Cord Injury and Disorders Center Hunter Holmes McGuire Veterans Administration Medical Center (VAMC) Richmond VA USA Department of Physical Medicine and Rehabilitation Virginia Commonwealth University Richmond VA USA Radiology Service Hunter Holmes McGuire Veterans Administration Medical Center (VAMC) Richmond VA USA

Shortly after spinal cord injury（SCI）, the musculoskeletal system undergoes detrimental changes in size and composition, predominantly below the level of injury. The loss of muscle size and strength, along with increased immobility, predisposes persons with SCI to rapid and severe loss in bone mineral density and other health related consequences. Previous studies have highlighted the significance of measuring thigh muscle cross-sectional area, however, measuring the size and composition of muscles of the lower leg may provide insights on how to decrease the risk of various comorbidities. The purpose of the current review was to summarize the methodological approach to manually trace and measure the muscles of the lower leg in individuals with SCI, using magnetic resonance imaging. We also intend to highlight the significance of analyzing lower leg muscle cross-sectional area and its relationship to musculoskeletal and vascular systems in persons with SCI.

关键词： spinal cord injury magnetic resonance imaging pressure ulcers venous thromboembolism cardiovascular disease bone health

Effect of caffeine on ovariectomy-induced osteoporosis in rats

在线全文

学校读者我要写书评

暂无评论

Effect of caffeine on ovariectomy-induced osteoporosis in ra...