检索结果-南通市图书馆

Highly bioactive nano-hydroxyapatite/partially stabilized zirconia ceramics

Journal of Bionic Engineering 2004年第4期1卷 215-220页

作者： WANG Qing-liang, GE Shi-rong, ZHANG De-kun College of Material Science and Engineering, China University of Mining and Technology, Xuzhou 221007, P.R. China 1 College of Material Science and Engineering China University of Mining and Technology Xuzhou 221007 P.R. China

Nanocrystalline hydroxyapatite (HA) powders have been synthesized by precipitation using Ca(NO3)2 4H2O and? (NH4)2 HPO4 at room temperature and atmospheric pressure. Nanocomposites of HA and partially stabilized zirconia (HA/PSZ) were sintered at atmospheric pressure and 1300 for 2h in air. The preparation techniques, structure and me- chanical properties of these materials were characterized. The addition of nanosized PSZ reinforcing phase to HA may lead to an improvement of the macro and micro mechanical properties and not affect its biocompatibility and bioactivity. The bending strength, fracture toughness and nano-hardness were near to or greater than those for human cortical bone and human tooth (dentine and enamel). The composite was incubated in a fresh human plasma which confirmed the bioactivity of nanosized HA/PSZ materials. The bonding reaction between HA/PSZ ceramic and the plasma proteins was found, and he- matopoietic cell phosphatase (HCP) layers formed on surface of each composite incubated in human plasma for two weeks. The diameter of a single HCP globule was less than 100 nm. Furthermore, the precipitating mechanism investigation was carried out through a comparative experiment in this paper.

关键词： bioactive ceramics hydroxyapatite PSZ nanoindentation mechanical properties 1

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Biomimetic hydroxyapatite coating on the 3D-printed bioactive porous composite ceramic scaffolds promoted osteogenic differentiation via PI3K/AKT/mTOR signaling pathways and facilitated bone regeneration in vivo

引用

Journal of Materials Science & Technology 2023年第5期136卷 54-64页

作者： Bizhi Tan Naru Zhao Wei Guo Fangli Huang Hao Hu Yan Chen Jungang Li Zemin Ling Zhiyuan Zou Rongcheng Hu Chun Liu Tiansheng Zheng Gang Wang Xiao Liu Yingjun Wang Xuenong Zou Guangdong Provincial Key Laboratory of Orthopaedics and Traumatology Department of Spine SurgeryThe First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China School of Materials Science and Engineering South China University of TechnologyGuangzhou 510641China National Engineering Research Center for Tissue Restoration and Reconstruction Guangdong Province Key Laboratory of Biomedical EngineeringSouth China University of TechnologyGuangzhou 510006China Department of Orthopedics The First Affiliated Hospital of Gannan Medical UniversityGanzhou 341000China

The architecture and surface modifications have been regarded as effective methods to enhance the bi-ological response of biomaterials in bone tissue *** porous architecture of the implanta-tion was essential conditions for bone ***,the design of biomimetic hydroxyap-atite(HAp)coating on porous scaffolds was demonstrated to strengthen the bioactivity and stimulate ***,bioactive bio-ceramics such asβ-tricalcium phosphate(β-TCP)and calcium sili-cate(CS)with superior apatite-forming ability were reported to present better osteogenic activity than that of *** in this study,3D-printed interconnected porous bioactive ceramicsβ-TCP/CS scaf-fold was fabricated and the biomimetic HAp apatite coating were constructed in situ via hydrothermal reaction,and the effects of HAp apatite layer on the fate of mouse bone mesenchymal stem cells(mBM-SCs)and the potential mechanisms were *** results indicated that HAp apatite coating en-hanced cell proliferation,alkaline phosphatase(ALP)activity,and osteogenic gene ***-more,PI3K/AKT/mTOR signaling pathway is proved to have an important impact on cellular *** present results demonstrated that the key molecules of phosphatidylinositol 3-kinase(PI3K),protein kinase B(AKT)and mammalian target of rapamycin(mTOR)were activated after the biomimetic hydrox-yapatite coating were constructed on the 3D-printed ceramic ***,the activated influence on the protein expression of Runx2 and BMP2 could be suppressed after the treatment of inhibitor *** vivo studies showed that the constructed HAp coating promoted bone formation and strengthen the bone *** results suggest that biomimetic HAp coating constructed on the 3D-printed bioac-tive composite scaffolds could strengthen the bioactivity and the obtained biomimetic multi-structured scaffolds might be a potential alternative bone graft for bone regeneration.

关键词： bioactive ceramics Hydroxyapatite coating 3D-printed porous ceramic scaffold PI3K/AKT/mTOR signaling pathway Bone regeneration

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

3D-printed bioactive ceramic scaffolds with biomimetic micro/nano-HAp surfaces mediated cell fate and promoted bone augmentation of the bone-implant interface in vivo

引用

bioactive Materials 2022年第6期7卷 120-132页

作者： Xiao Liu Yali Miao Haifeng Liang Jingjing Diao Lijing Hao Zhifeng Shi Naru Zhao Yingjun Wang National Engineering Research Center for Tissue Restoration and Reconstruction GuangzhouChina School of Materials Science and Engineering South China University of TechnologyGuangzhou510641China Guangdong Province Key Laboratory of Biomedical Engineering South China University of TechnologyGuangzhou510006China Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education South China University of TechnologyGuangzhou510006PR China Innovation Center for Tissue Restoration and Reconstruction South China University of TechnologyGuangzhou510006PR China Department of Orthopedics Zhujiang HospitalSouthern Medical UniversityNo.253 Industrial AvenueHaizhuGuangzhou510280People’s Republic of China Medical Devices Research&Testing Center of SCUT Guangzhou510006PR China Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) 510005 GuangzhouChina

Calcium phosphate bio-ceramics are osteo-conductive,but it remains a challenge to promote the induction of bone augmentation and capillary *** surface micro/nano-topography of materials can be recognized by cells and then the cell fate are *** regulation methods of carving surface structures on bio-ceramics employ mineral reagents and organic additives,which might introduce impurity phases and affect the biological *** a previous study,a facile and novel method was utilized with ultrapure water as the unique reagent for hydrothermal treatment,and a uniform hydroxyapatite(HAp)surface layer was constructed on composite ceramics(β-TCP/CaSiO_(3))in *** combined with 3D printing technology,biomimetic hierarchical structure scaffolds were fabricated with interconnected porous composite ceramic scaffolds as the architecture and micro/nano-rod hybrid HAp as the surface *** obtained HAp surface layer favoured cell adhesion,alleviated the cytotoxicity of precursor scaffolds,and upregulated the cellular differentiation of mBMSCs and gene expression of HUVECs in *** vivo studies showed that capillary formation,bone augmentation and new bone matrix formation were upregulated after the HAp surface layer was obtained,and the results confirmed that the fabricated biomimetic hierarchical structure scaffold could be an effective candidate for bone regeneration.

关键词： 3D printed porous scaffold bioactive ceramics HAp surface layer Cell fate mediation Bone augmentation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Effect of Bioceramic Composite Extracellular Matrixes Used to Repair Bone Deficiency on Relevant Blood Biochemical Indices

引用

Chinese Journal of Biomedical Engineering(English Edition) 2007年第2期16卷 47-54,92页

作者： ZHU Ming-hua ZENG Yi WANG Lin SUN Tao PENG Qiang YE Chang-ning Sichuan Provincial Center for Disease Control and Prevention Chengdu 610041 China People＇ s Hospital of Sichuan Province Chengdu 610072 China

At the base of experimental animal model construction of bone defect in New Zealand rabbit, the promoting repair effect of bioactive ceramics on bone defect as well as its machanism was studied through testing body mineral elements, enzymes related to bone morphogenetic proteins and some biochemical indexes. Refering to some documents, materials of TCP, CHA and HA were combined and TCP/BMP/ TCP-β1 and CHA/BMP/ TCP-β1,HA/BMP/ TCP-β1 composite materials were made. All kinds of them were implanted into the radial defect site of rabbit, respectively. The chosen blood indexes (Ca, P, ALP, GGT, AST, ALT, TPA, BUN and Cr) were tested by colorimetry, speed rate and bromocresol green testing methods. No abnormal effects were found in any animal after operation. Serum concentrations of Ca, P and ALP were increased with the length of time in all groups of the three kinds of composite material, mixed material and pure materials. The increases in composite material groups were more significant (PCHA>HA. There was a tendency of increased TPA and decreased BUN with the length of time. There was no significant difference between the composite material groups and pure material group (P>0.05). The three kinds of bioactive ceramics composed of extracellular matrix could increase the serum concentrations of Ca and P and activity of ALP after being implanted into defect bone and showed some repairing capacity. This provided a new area of machanism study of bone defect repair by biomaterials.

关键词： bioactive ceramics extracellular matrix biochemical indexes bone defect

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

钛合金表面生物活性陶瓷涂层的制备

钛合金表面生物活性陶瓷涂层的制备

引用

全国首届青年复合材料学术交流会

作者：杨巍杨贤金朱胜利崔振铎天津大学材料科学与工程学院天津大学材料科学与工程学院天津大学材料科学与工程学院天津大学材料科学与工程学院

设计并制备一系列热膨胀系数与Ti6Al4V相匹配的生物活性瓷粉,其中6PM-B5-F4瓷粉的热膨胀系数为10.1×10-6×℃-1,与本研究所用的Ti6Al4V的热膨胀系数（10.8×10-6×℃-1）最为接近。瓷粉的熔制工艺为1350℃保温3小时。采用搪瓷涂覆法于T... 详细信息

设计并制备一系列热膨胀系数与Ti6Al4V相匹配的生物活性瓷粉,其中6PM-B5-F4瓷粉的热膨胀系数为10.1×10-6×℃-1,与本研究所用的Ti6Al4V的热膨胀系数（10.8×10-6×℃-1）最为接近。瓷粉的熔制工艺为1350℃保温3小时。采用搪瓷涂覆法于Ti6Al4V表面制备涂层,确定制备涂层的最佳烧结工艺为软化点温度保温30min,快速升温到750℃保温5min。所制备涂层厚度约50μm,结合强度8.5MPa。扫描电镜观察涂层表面及界面形貌。

关键词： bioactive ceramics Ti6Al4V coating

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：