检索结果-南通市图书馆

Janus hydrogel with dual antibacterial and angiogenesis functions for enhanced diabetic wound healing

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2023年第4期34卷 122-126页

作者： Guiting Liu Yuan Zhou Zejun Xu Ziting Bao Li Zheng Jun Wu The State Key Laboratory of Polymer Materials Engineering Polymer Research Institute of Sichuan UniversityChengdu 610065China Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat-sen Memorial Hospital Sun Yat-sen UniversityGuangzhou 510120China School of Biomedical Engineering Sun Yat-sen UniversityGuangzhou 510006China Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration Life Science InstitutesGuangxi Medical UniversityNanning 530021China Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and Ministry Guangxi Medical UniversityNanning 530021China

Anti-infection and neovascularization at the wound site are two vital factors that accelerate diabetic wound healing. However, for a wound healing dressing, the two functions need to work at different sites(inner and outer), giving big challenges for dressing design. In this study, we fabricated a novel sodium alginate/chitosan(SA/CS) Janus hydrogel dressing by the assembly of SA hydrogel loaded with silver nanoparticles(Ag NPs) and CS hydrogel impregnated with L-arginine loaded sodium alginate microspheres(Arg MSs) based on electrostatic interactions to combine the two functions. The outer SA-Ag NP hydrogel could prevent infection while avoiding the deposition of Ag NPs in the wound site, and the inner CS-Arg MS hydrogel on the wound surface could realize the sustained release of L-arginine and promote vascular regeneration. The composition, morphology and swelling/degradation of the SA-Ag NP/CS-Arg MS hydrogel were characterized systematically. L-Arginine release behavior has been tested and SA-Ag NP/CSArg MS hydrogel has been confirmed for excellent biocompatibility. antibacterial and angiogenesis assays demonstrated the antibacterial and angiogenesis characteristics of the SA-Ag NP/CS-Arg MS hydrogel. Finally, in vivo diabetic wound healing assay demonstrated that the SA-Ag NP/CS-Arg MS hydrogel could significantly accelerate re-epithelialization, granulation tissue formation, collagen deposition and angiogenesis, thereby resulting in enhanced diabetic wound healing。

关键词： Janus hydrogel antibacterial Angiogenesis Diabetic wound Wound healing

Hyaluronic acid-methacrylic anhydride/polyhexamethylene biguanide hybrid hydrogel with antibacterial and proangiogenic functions for diabetic wound repair

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2022年第12期33卷 5030-5034页

作者： Yike Li Huiyu Zheng Yaxian Liang Ming Xuan Guiting Liu Huixu Xie State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesWest China Hospital of StomatologyState Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610041China

Diabetic wounds lead to a decrease in quality of life and an increase in *** treatment strategies include preventing bacterial adhesion while improving *** a new type of wound dressing that imitates natural skin,hydrogel has gradually emerged with its excellent ***,existing hydrogels rarely achieve satisfactory results in promoting wound repair and antibacterial *** this case,we prepared methacrylic anhydride chemically modified hyaluronic acid as a hydrogel matrix,added polyhexamethylene biguanide as an antibacterial component,and loaded sodium alginate/salidroside composite microspheres which could sustainably release salidroside and thus promote *** hydrogel(HAMA/PHMB-Ms)was synthesized via photocrosslinking,and its chemical structure,particle size distribution and microstructure were *** satisfactory antibacterial properties of the HAMA/PHMB(15%)-Ms hydrogel were studied in vitro,and its antibacterial rates against *** and *** were 97.85%and 98.56%,*** addition,after demonstrating its good biocompatibility,we verified that the HAMA/PHMB-Ms hydrogel has increased granulation tissue formation,more collagen deposition,more subcutaneous capillary formation,and better wound healing than blank control,HAMA and HAMA/PHMB hydrogel on the back wound model of diabetic *** results confirmed that HAMA/PHMB-Ms hydrogel was a promising material for the treatment of the diabetic wounds.

关键词： Hydrogel Diabetic wounds antibacterial Angiogenesis

An ultra-highly active nanozyme of Fe,N co-doped ultrathin hollow carbon framework for antibacterial application

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2023年第3期34卷 388-391页

作者： Jinyu Hao Cui Zhang Chenxi Feng Qian Wang Zhong-Yi Liu Yan Li Jianshuai Mu En-Cui Yang Yan Wang College of Chemistry Tianjin Key Laboratory of Structure and Performance for Functional MoleculesTianjin Normal UniversityTianjin 300387China School of Chemistry and Chemical Engineering Harbin Institute of TechnologyHarbin 150001China School of food and Bioengineering Xuzhou University of TechnologyXuzhou 221018China

In recent years, nanozymes have received more and more attention, but the low activity limits the development of nanozymes. Therefore, the design and development of efficient nanozymes is still a major challenge for researchers. Herein, the Fe,N co-doped ultrathin hollow carbon framework(Fe,N-UHCF) exhibit ultra-high peroxidase-like activity. The specific activity of Fe,N-UHCF nanozyme is as high as 36.6 U/mg,which is much higher than almost all of other reported nanozymes. In practical applications, the Fe,N-UHCF show good antibacterial effects.

关键词： Peroxidase-like Nanozyme Ultra-highly active Specific activity antibacterial

Triple-synergistic MOF-nanozyme for efficient antibacterial treatment

在线全文

学校读者我要写书评

暂无评论

Bioactive Materials 2022年第11期7卷 289-299页

作者： Muxue Wang Xi Zhou Yunhong Li Yuqing Dong Jiashen Meng Shuai Zhang Linbo Xia Zhaozhi He Lei Ren Zhiwei Chen Xingcai Zhang Department of Electronic Science Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance ResearchSchool of Electronic Science and EngineeringXiamen UniversityXiamen361005People’s Republic of China The Higher Educational Key Laboratory for Biomedical Engineering of Fujian Province Research Center of Biomedical Engineering of XiamenDepartment of BiomaterialsCollege of MaterialsXiamen UniversityXiamen361005People’s Republic of China John A Paulson School of Engineering and Applied Sciences Harvard UniversityCambridgeMA02138USA School of Engineering Massachusetts Institute of TechnologyCambridgeMA02139USA

The abuse of antibiotics makes bacterial infection an increasingly serious global health threat. Reactive oxygen species (ROS) are the ideal alternative antibacterial approach for quick and effective sterilization. Although various antibacterial strategies based on ROS have been developed, many of them are still limited by insufficient antibacterial efficiency. Here, we have developed an acid-enhanced dual-modal antibacterial strategy based on zeolitic imidazolate frameworks-8 (ZIF8) -derived nanozyme. ZIF8, which can release Zn2+, is chosen as the carrier to integrate glucose oxidase (GOx) and gold nanoparticles (Au NPs) which can produce ROS via a cascade catalytic reaction. Thus, the bactericidal capability of ROS and Zn2+ have been integrated. More importantly, gluconic acid, a “by-product” of the catalytic reaction, can generate an acidic environment to promote both the ROS-producing and Zn2+-releasing, enhancing the overall antibacterial performance further. This triple-synergistic strategy exhibits extraordinary bactericidal ability at a low dosage of 4 μg/mL (for S. aureus) and 8 μg/mL (for E. coli), which shows a great potential of MOF-derived nanozyme for efficient bacterial eradication and diverse biomedical applications.

关键词： Metal-organic frameworks Nanozyme Reactive oxygen species antibacterial Zinc ion

Mussel-inspired adhesive antioxidant antibacterial hemostatic composite hydrogel wound dressing via photo-polymerization for infected skin wound healing

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bioactive Materials 2022年第2期7卷 341-354页

作者： Yutong Yang Yongping Liang Jueying Chen Xianglong Duan Baolin Guo Second Department of General Surgery Shaanxi Provincial People’s HospitalXi’an710068China Frontier Institute of Science and Technology and State Key Laboratory for Mechanical Behavior of Materialsand Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine ResearchCollege of StomatologyXi’an Jiaotong UniversityXi’an710049China Second Department of General Surgery Third Affiliated Hospital of Xi’an Jiaotong UniversityXi’an710068China

With the increasing prevalence of drug-resistant bacterial infections and the slow healing of chronically infected wounds,the development of new antibacterial and accelerated wound healing dressings has become a serious *** order to solve this problem,we developed photo-crosslinked multifunctional antibacterial adhesive anti-oxidant hemostatic hydrogel dressings based on polyethylene glycol monomethyl ether modified glycidyl methacrylate functionalized chitosan(CSG-PEG),methacrylamide dopamine(DMA)and zinc ion for disinfection of drug-resistant bacteria and promoting wound *** mechanical properties,rheological properties and morphology of hydrogels were characterized,and the biocompatibility of these hydrogels was studied through cell compatibility and blood compatibility *** hydrogels were tested for the in vitro blood-clotting ability of whole blood and showed good hemostatic ability in the mouse liver hemorrhage model and the mouse-tail amputation *** addition,it has been confirmed that the multifunctional hydrogels have good inherent antibacterial properties against Methicillin-resistant Staphylococcus aureus(MRSA).In the full-thickness skin defect model infected with MRSA,the wound closure ratio,thickness of granulation tissue,number of collagen deposition,regeneration of blood vessels and hair follicles were *** inflammation-related cytokines(CD68)and angiogenesis-related cytokines(CD31)expressed during skin regeneration were *** results indicate that these multifunctional antibacterial adhesive hemostatic hydrogels have better healing effects than commercially available Tegaderm™Film,revealing that they have become promising alternative in the healing of infected wounds.

关键词： Chitosan Wound dressing antibacterial Wound healing Hemostat Infected skin wound

Gallium containing bioactive materials: A review of anticancer, antibacterial, and osteogenic properties

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bioactive Materials 2022年第11期7卷 125-146页

作者： Fatih Kurtuldu Nurshen Mutlu Aldo R.Boccaccini Dusan Galusek FunGlass Alexander Dubcek University of TrencínStudentska 291150TrencínSlovakia Institute of Biomaterials Department of Material Science and EngineeringUniversity of Erlangen-Nuremberg91058ErlangenGermany Joint Glass Centre of the IIC SAS TnUAD and FChFT STUStudentska 291150TrencínSlovakia

The incorporation of gallium into bioactive materials has been reported to enhance osteogenesis,to influence blood clotting,and to induce anti-cancer and anti-bacterial ***-doped biomaterials prepared by various techniques include melt-derived and sol-gel-derived bioactive glasses,calcium phosphate bioceramics,metals and *** this review,we summarize the recently reported developments in antibacterial,anti-cancer,osteogenesis,and hemostasis properties of Ga-doped biomaterials and briefly outline the mechanisms leading to Ga biological *** key finding is that gallium addition to biomaterials has great potential for treating bone-related diseases since it can be efficiently transferred to the desired region at a controllable ***,it can be used as a potential substitute for antibiotics for the inhibition of infections during the initial and advanced phases of the wound healing *** is also used as an anticancer agent due to the increased concentration of gallium around excessive cell proliferation(tumor)***,we highlight the possibility to design different therapeutic approaches aimed at increasing the efficiency of the use of gallium containing bioactive materials for multifunctional applications.

关键词： antibacterial Bioactive materials Cancer treatment Hemostasis Osteogenesis

Next-generation finely controlled graded porous antibacterial bioceramics for high-efficiency vascularization in orbital reconstruction

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bioactive Materials 2022年第10期7卷 334-345页

作者： Jingyi Wang Yiyu Peng Menglu Chen Xizhe Dai Lixia Lou Changjun Wang Zhaonan Bao Xianyan Yang Zhongru Gou Juan Ye Eye Center The Second Affiliated HospitalZhejiang University School of MedicineZhejiang Provincial Key Lab of OphthalmologyHangzhou310009PR China Department of Ophthalmology The Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou310051PR China Zhejiang-California International NanoSystems Institute Zhejiang UniversityHangzhou310029PR China

Eyeball loss due to severe ocular trauma,intraocular malignancy or infection often requires surgical treatment called orbital implant reconstruction to rehabilitate the orbital volume and restore the aesthetic ***,it remains a challenge to minimize the postoperative exposure and infection complications due to the inert nature of conventional orbital ***,we developed a novel Ca-Zn-silicate bioceramic implant with multi-functions to achieve the expected *** porous hardystonite(Ca2ZnSi2O7)scaffolds with triply periodic minimal surfaces(TPMS)-based pore architecture and graded pore size distribution from center to periphery(from 500 to 800μm or vice versa)were fabricated through the digital light processing(DLP)technique,and the scaffolds with homogeneous pores(500 or 800μm)were fabricated as *** graded porous scaffolds exhibited a controlled bio-dissolving behavior and intermediate mechanical strength in comparison with the homogeneous counterparts,although all of porous implants presented significant antibacterial potential against *** and ***,the pore size-increasing scaffolds indicated more substantial cell adhesion,cell viability and angiogenesis-related gene expression in ***,the gradually increasing pore feature exhibited a stronger blood vessel infiltrating potential in the dorsal muscle embedding model,and the spherical implants with such pore structure could achieve complete vascularization within 4 weeks in the eyeball enucleation rabbit ***,our results suggested that the novel antibacterial hardystonite bioceramic with graded pore design has excellent potential as a next-generation orbital implant,and the pore topological features offer an opportunity for the improvement of biological performances in orbital reconstruction.

关键词： Graded porous scaffolds Fibro-vascularization antibacterial Hardystonite Orbital implants

The synthesis and antibacterial activity evaluation of oxazolidinone-deferasirox conjugates

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Chinese Pharmaceutical Sciences 2022年第12期31卷 946-952页

作者： Xintong Zhao Yuhua Hu Tong Qin Tianlei Li Wenxuan Zhang Song Wu State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaPeking Union Medical College and Chinese Academy of Medical SciencesBeijing 100050China

We reported herein the synthesis and antibacterial activity evaluation of two oxazolidinone-deferasirox conjugates with different linkers that were designed based on the“Trojan horse”*** conjugates could combine with Fe^(3+)ions as the ***,both conjugates were inactive against tested bacteria,including ***,***,***,and *** results suggested that the synthesized iron chelator deferasirox was not suitable as a siderophore of the bacteria to transport the antibiotic,or the coupling linker of the synthesized conjugates could not be hydrolyzed to release the oxazolidinone in the ***,the design and synthesis of oxazolidinone-deferasirox conjugates need further exploration.

关键词： Oxazolidinone Deferasirox antibacterial Siderophore “Trojan horse”strategy

LncRNA MIR144HG-derived miR-144 suppresses antibacterial signaling and facilitates bacteria escape in fish

在线全文

学校读者我要写书评

暂无评论

Water Biology and Security 2023年第1期2卷 72-85页

作者： Weiwei Zheng Junxia Cui Xing Lv Shiying Xin Tianjun Xu Laboratory of Fish Molecular Immunology College of Fisheries and Life ScienceShanghai Ocean UniversityShanghai201306China Laboratory of Marine Biology and Biotechnology Qingdao National Laboratory for Marine Science and TechnologyQingdao266200China Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources(Shanghai Ocean University) Ministry of EducationShanghai201306China National Pathogen Collection Center for Aquatic Animals Shanghai Ocean UniversityShanghai201306China

Growing number studies show that lncRNA is an important regulatory factor and plays an irreplaceable role in innate ***,most studies on lncRNA have focused on mammals and it is unknown in lower *** this study,we identify a new lncRNA,named MIR144HG,which can have a negative role in antibacterial immunity of Miichthys miiuy caused by Vibrio anguillarum and ***88,TAK1 and p65 are very important pathway genes in antibacterial innate immune responses,whether in mammals or lower ***,we found that miR-144–3p could target MyD88,TAK1 and p65,inhibit host antibacterial response and promote bacterial *** studies found that miR-144–3p can be derived by MIR144HG,and finally enhance the inhibitory effect of miR-144–3p on host antibacterial ***,*** and *** are the two most susceptible Gram-negative pathogens in aquaculture,and the economic losses caused by these two bacteria are immeasurable every *** results not only elucidate the mechanism of the lncRNAmiRNA-mRNA axis in antibacterial immune responses,but also provide new insights for understanding the impact of lncRNA on host immunity and bacteria escape.

关键词： antibacterial Fish Innate immunity lncRNA microRNA Precursor