LncRNA MIR144HG-derived miR-144 suppresses antibacterial signaling and facilitates bacteria escape in fish
作者机构：Laboratory of Fish Molecular ImmunologyCollege of Fisheries and Life ScienceShanghai Ocean UniversityShanghai201306China Laboratory of Marine Biology and BiotechnologyQingdao National Laboratory for Marine Science and TechnologyQingdao266200China Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources(Shanghai Ocean University)Ministry of EducationShanghai201306China National Pathogen Collection Center for Aquatic AnimalsShanghai Ocean UniversityShanghai201306China
出 版 物：《Water Biology and Security》 (水生生物与安全（英文）)
年 卷 期：2023年第2卷第1期
页 面：72-85页
基 金：This study was supported by the National Key Research and Devel-opment Project(2018YFD0900503) the National Natural Science Foundation of China(31822057)
主 题：Antibacterial Fish Innate immunity lncRNA microRNA Precursor
摘 要：Growing number studies show that lncRNA is an important regulatory factor and plays an irreplaceable role in innate ***,most studies on lncRNA have focused on mammals and it is unknown in lower *** this study,we identify a new lncRNA,named MIR144HG,which can have a negative role in antibacterial immunity of Miichthys miiuy caused by Vibrio anguillarum and ***88,TAK1 and p65 are very important pathway genes in antibacterial innate immune responses,whether in mammals or lower ***,we found that miR-144–3p could target MyD88,TAK1 and p65,inhibit host antibacterial response and promote bacterial *** studies found that miR-144–3p can be derived by MIR144HG,and finally enhance the inhibitory effect of miR-144–3p on host antibacterial ***,*** and *** are the two most susceptible Gram-negative pathogens in aquaculture,and the economic losses caused by these two bacteria are immeasurable every *** results not only elucidate the mechanism of the lncRNAmiRNA-mRNA axis in antibacterial immune responses,but also provide new insights for understanding the impact of lncRNA on host immunity and bacteria escape.
维普期刊数据库