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Treatment of infant postrenal acute renal failure followingobstruction due to upper urinary calculi

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Frontiers of Medicine 2010年第1期4卷 127-130页

作者： Hui-Xia ZHOU Zhi-Chun FENG Hao MENG Xiao-Guang ZHOU Shuang LI Jun WANG Shi-Xi DAI Department of Urology Bayi Children’s HospitalGeneral Hospital of Beijing Military RegionBeijing 100700China Department of Urology Wuhan Children’s HospitalWuhan 430030China

The surgical emergency treatments and cura-tive effects of postrenal acute renal failure following obstruction due to upper urinary calculi in infants were *** the 13 infants with postrenal acute renal failure following obstruction due to upper urinary calculi,11 received retrograded catheterizations of the ureter with semi-rigid ureteroscopy(F 6.8),and two received open *** results showed that only one infant had anuresis and continuous reduction of hemoglobin 5 h after the open ureterolithotomy and received exploration via excision and peritoneal dialysis,and the remaining 12 patients well recovered in this *** renal function of all the patients was restored without postoperative *** is concluded that the retrograded catheterization of the ureter with ureteroscopy is a minimally invasive,safe and effective therapy for postrenal acute renal failure following obstruction due to upper urinary calculi in *** those infants whose urethras are thin and small,the open ureterolithotomy is a suitable *** patients with bleeding tendency need to be corrected prior to the open ureterotomy to remove obstructions.

关键词： infant acute renal failure postrenal uretero-scopy

acute renal failure in COVID-19 Patients in Intensive Care at the CHU du Point G in Mali

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Open Journal of Nephrology 2023年第4期13卷 385-394页

作者： Diallo Boubacar Coulibaly Nouhoum Dicko Hammadoun Berthe Modibo Beye Seydina Alioune Niangado Rokiatou Bassirou Keita Mohamed Coulibaly Youssouf Department of Anaesthesia-Resuscitation and Emergencies CHU Point G Bamako Mali Department of Nephrology and Haemodialysis CHU Point G Bamako Mali

Introduction: SARS-CoV-2 (Severe acute Respiratory Syndrome Corona-virus 2) causes an acute respiratory disease with interstitial and alveolar pneumonia, which can affect several organs including the kidneys [1] [2] [3]. As Mali is no stranger to this pandemic, we report our experience of the management of cases of kidney failure observed in the COVID-19 intensive care unit at the Point G University Hospital Centre (CHU). The aim of this work was to characterise acute renal failure in COVID-19 patients in intensive care, describing the management methods used and determining the vital prognosis. Materials and Methods: This was a retrospective descriptive study, covering an 18-month period from April 2020 to September 2021. We included all patients admitted to the COVID-19 intensive care unit on the basis of a positive RT-PCR and/or the presence of ground-glass images on thoracic computed tomography. Results: We selected 232 patients admitted for COVID-19. acute renal failure (ARF) developed in 71 patients (30.6%). The stages of AKI according to KDIGO were Stage 1 in 28.2%, Stage 2 in 18.3% and Stage 3 in 53.5%. The mean age was 63.96 years, with a standard deviation of 16.6, and males accounted for the majority (71.8%). Organic ARF was found in 80.3% of cases. Risk factors and comorbidities for ARF included advanced age (60.6%), male sex (71.8%), hypertension (52.1%), diabetes (21.1%), invasive mechanical ventilation (71.8%) and septic shock (56.3%). Extra renal purification (haemodialysis) was used in 29.6% of patients. Admission to intensive care ranged from 7 days to 14 days in 43.7% of cases. More than half the patients (52.1%) were in critical condition on admission. Death occurred in 76.1% of patients. Conclusion: ARF appears to occur more frequently in patients with severe COVID-19. It is associated with a poor prognosis.

关键词： COVID-19 acute renal failure Intensive Care Unit

acute renal failure Secondary to Paracetamol Intoxication: A Case Report

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Open Journal of Nephrology 2022年第3期12卷 235-240页

作者： Moctar Coulibaly Magara Samaké Konaré Samba Fofana Aboubacar Sidiki Ossil Ampion Marc Batcho Jimmy Mansour Janette Seydou Sy Hamadoun Yattara Atabième Kodio Djénéba Maiga Sah Dit Baba Coulibaly Djénèba Diallo Aboudou M. Dolo Moustapha Tangara Nouhoum Coulibaly Kalilou Coulibaly Ibrahima Koné Saharé Fongoro Nephrology Unit of Mali GAVARDO Hospital in Sebénicoro Bamako Mali Nephrology Unit of the Fousseyni DAOU Hospital Kayes Mali National Center for Scientific and Technological Research (CNRST) Bamako Mali Nephrology Department of the Soissons Hospital Soissons France Nephrology and Hemodialysis Department of the UHC du Point G Bamako Mali Faculty of Medicine of Bamako Bamako Mali Nephrology Unit of Sikasso Hospital Sikasso Mali Nephrology Unit of Somino DOLO Hospital Mopti Mali

renal damage secondary to paracetamol intoxication is rare, estimated between 1% and 2% of intoxication cases. Its pathophysiology is still debated, the clinical involvement consisting in an acute tubular necrosis with a good prognosis if it is rapidly treated. renal damage can sometimes occur without prior hepatic damage, and the onset of renal manifestations is generally between the 2nd and 7th day after taking paracetamol. If its management remains exclusively symptomatic, its late onset can sometimes lead to serious metabolic complications. It is therefore important to systematically monitor renal function following paracetamol drug intoxication. We report the case of a 60-year-old male subject hospitalized for the management of voluntary drug intoxication (VDI) with paracetamol complicated by acute hepatocellular failure and acute renal failure. His management required extrarenal purification (hemodialysis) and the evolution was favorable with recovery ad integrumof renal function. Conclusion: Although less known and of unelucidated physiopathology, nephrotoxicity secondary to voluntary drug intoxication with paracetamol is a reality and can lead in extreme cases to the use of extrarenal purification technique (hemodialysis).

关键词： acute renal failure Paracetamol Intoxication Hemodialysis

Prophylaxis and Therapy of Isaria felina on acute renal failure Induced by Glycerin in Rats

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Chinese Herbal Medicines 2012年第4期4卷 319-323页

作者： YANG Xi-hua2,3,ZHANG Sheng-wan1,REN Lian-sheng3,BAI Xi-hua3 1.College of Life Science,Shanxi University,Taiyuan 030006,China 2.College of Chemistry and Chemical Engineering,Shanxi University,Taiyuan 030006,China 3.Department of Comparative Medicine,Shanxi Cancer Institute,Taiyuan 030013,China College of Chemistry and Chemical Engineering Shanxi UniversityTaiyuan 030006China Department of Comparative Medicine Shanxi Cancer InstituteTaiyuan 030013China College of Life Science Shanxi UniversityTaiyuan 030006China Department of Comparative Medicine Shanxi Cancer InstituteTaiyuan 030013China

Objective To evaluate the prophylaxis and therapy of Isaria felina(IF) on glycerin-induced acute renal failure(ARF) in *** Forty male Wistar rats were divided into control,model,Uremic Clearance Granule(UCG,positive control),high-and low-dose IF *** in the high-and low-dose IF groups were ig administered with 200 and 100 mg/kg IF,respectively,while rats were ig administered with 3.6 g/kg UCG successively for 7 d to establish UCG *** rats in model,control,and drug-treated groups were im injected with 8 mL/kg 50% glycerin after drinking was quitted for 24 h to induce ARF in *** drugs were continued to give *** level of blood urea nitrogen(BUN) and serum creatinine(SCr) were determined 24 and 72 h after the injection of glycerin,also the kidney was dissected for pathology *** Im injection with 8 mL/kg 50% glycerin could successfully induce ARF in *** dose of 200 mg/kg IF could reduce the high levels of BUN and SCr,and ameliorate the pathological damage of the *** IF has good protective and therapeutic effects on ARF and it is a potential and valuable Chinese herb for ARF.

关键词： acute renal failure blood urea nitrogen glycerin Isaria felina serum creatinine

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acute renal failure in the Elderly in the Nephrology Department of Aristide Le Dantec Hospital in Senegal: About 45 Cases

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Open Journal of Nephrology 2023年第4期13卷 451-463页

作者： Arlette Géraldine Nguea Ndjame Ameth Dieng Vincent Ebenezer Ngamby Mamadou Coume El Hadji Fary Ka Maria Fall Ahmed Tall Lemrabott Mouhamadou Moustapha Cisse Abdou Niang Department of Clinical Sciences Faculty of Medicine and Pharmaceutical Sciences University of Douala Douala Cameroon Central Hospital of Yaoundé Yaoundé Cameroon Health Sciences Training and Research Unit University of Thiès Thiès Senegal Regional Hospital of Thiès Thiès Senegal Faculty of Medicine Pharmacy and Odontology Cheikh Anta Diop University Dakar Senegal National University Hospital of Fann Dakar Senegal Aristide Le Dantec Hospital Dakar Senegal Dalal Jamm National University Hospital of Guédiawaye Dakar Senegal

Introduction: The incidence of acute renal failure (ARF) increases with age. In Senegal, few studies have described the epidemiology of ARF in the elderly. The aim of our study is to establish the epidemiological profile of elderly patients with ARF, identify the causes of ARF in the elderly and assess treatment and prognosis. Methods: We conducted a descriptive and retrospective study over a five-year period from 2011 to 2015 involving patients aged 60 and over, treated for ARI during the study period. Data entry and analysis were done on Epi info 7.3. Results: We included a total of 45 patients. The prevalence of ARF was 3.34%. The mean age was 70.31 years (60 - 83) and the sex ratio was 3.5. Phytotherapy was found in 68.9%, hypertension was found in 68.9%, and diabetes was found in 31.1%. Prostate hypertrophy was found in 53.4% of patients. Pre-renal ARF was the most common (46.6%). Most of the cases, 66.67%, were at Stage 3 of KDIGO. The most common etiologies were respectively tumor (35.5%) and infection (20%). The most common complications were respectively hyperkalemia (33.3%) and hyponatremia (33.3%). Recovery was complete in 62.6% of cases, partial in 37.8% of patients and 13.3% of patients ended up on chronic hemodialysis. Mortality was 4.4%. Conclusion: Herbal medicine, hypertension and diabetes are frequently associated with ARF in the elderly. This justifies increased monitoring of the elderly subject with these conditions in order to subject him to early and appropriate care.

关键词： acute renal failure Elderly Epidemiology

acute renal failure AFTER OPEN-HEART OPERATION

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Journal of Pharmaceutical Analysis 1996年第1期10卷 60-62,69页

作者：贺定超秦志端鲁舒林

Eight Patients with acute renal failure who received open-heart operation were compared with other eight patients without renal failure.A method or early diagnosis or acute renal failure was *** kidney function deteriorated, the urinary output decreased dramatically,meanwhile the blood urea nitrogen began to rise,two lines crossed and formed a valuable *** they never crossed in patients without renal *** we used perito-dialysis to treat these patients and got good result.

关键词： acute renal failure pen-heart operation cardiopulmonary bypass

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AMINO ACIDS' PROTECTIVE EFFECTS ON EXPERIMENTAL acute renal failure

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2000年第2期 95-100页

作者：谢立平

This study was carried out to elucidate the nephroprotective effects from a mixture of 8 L amino acids and the possible mechanism of protection by this amino acid mixture. acute renal failure model was induced by an intravenous administration of 10 mg/kg cisplatin to male Sprague Dawley rats. A mixture of 8 L amino acids or 0.9% saline was infused at a rate of 2 ml/h for 3 h, starting with a 2 ml bolus injection before cisplatin administration. Amino acids showed no acute effect on renal morphology. The infusion of a mixture of 8 L amino acids increased GFR by 85% in control rats. The abnormalities of urine sodium and potassium excretion caused by cisplatin were markedly attenuated by the administration of the amino acid mixture. With the infusion of this amino acid mixture, cisplatin induced abnormal state 4 respiration returned to control levels and the depressed state 3 respiration, respiratory control ratio and carbonyl cyanide p trifluoromethoxyphenyl hydrazone uncoupled respiration were ameliorated remarkably. A mixture of 8 L amino acids showed marked nephroprotection against cisplatin induced acute renal failure in rats and might function through augmentation of the cisplatin injured renal mitochondrial electron transport oxidative phosphorylation sequence, probably via stabilizing the membrane (including inner mitochondrial membrane) protein tertiary structure. In addition, this amino acid mixture remarkably increased GFR and decreased urine sodium excretion in rats.

关键词： acute renal failure cisplatin nephroprotection amino acids kidney tubule mitochondria

MITOCHONDRIAL DYSFUNCTION AT THE EARLY STAGE OF CISPLATIN-INDUCED acute renal failure IN RATS

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2000年第1期 94-99页

作者：谢立平 C.Skrezek H.Wand F.Reibe

The present study was undertaken to clarify the pathogenesis of cisplatin induced acute renal failure at the early stage. Male Sprague Dawley rats were given an intravenous administration of 10 mg/kg cisplatin. 0.9% saline was infused into them at a rate of 2 ml/h for 3 h, starting with a 2 ml bolus injection before cisplatin administration. 3 h following cisplatin administration, no evident morphological abnormalities were found by both light and electron microscopy; there were also no significant changes in GFR. Thirty min after cisplatin injection, urine sodium and potassium excretion increased by 56% and 260% those of the control animals, respectively. Apparent renal mitochondrial respiration dysfunction was observed in cisplatin treated rats 3 h later; the state 4 respiration increased by 100% and state 3 respiration, respiratory control ratio and carbonyl cyanide p trifluoromethoxyphenyl hydrazone uncoupled respiration decreased by 46%, 74% and 47% of the controls, respectively. The present data suggest that mitochondrial dysfunction may be a very early event in cisplatin induced acute renal failure in rats.

关键词： acute renal failure cisplatin pathogenesis kidney tubule mitochondria

Prognostic values of serum cystatin C and β2 microglobulin, urinary β2 microglobulin and N-acetyl-β-D-glucosaminidase in early acute renal failure after liver transplantation

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Chinese Medical Journal 2008年第14期121卷 1251-1256页

作者： HEI Zi-qing LI Xiao-yun SHEN Ning PANG Hong-yu ZHOU Shao-li GUAN Jian-qiang Department of Anesthesiology Third Affiliated Hospital Sun Yat-sen University Guangzhou Guangdong 510630 China

Background acute renal failure （ARF） after liver transplantation is associated with high mortality and morbidity. Early therapeutic or preventive intervention is hampered by the lack of early effective prognostic factors. Recent studies indicated that serum levels of cystatin C and β2-microglobulin （β2 MG） as well as urinary β2 MG and N-acetyI-β-D- glucosaminidase （NAG） would increase in patients with early and mild renal impairment. In this study, these factors were detected during the different stages in patients who accepted orthotopic liver transplantation （OLT）, and their feasibilities to predict early ARF after OLT were also analyzed. Methods Sixty patients with normal blood urea nitrogen （BUN） and serum creatinine （SCr） who received modified piggyback liver transplantation without veno-venous bypass were prospectively studied. Blood samples were drawn from patients for the determination of serum β2 MG（n=60）, SCr （n=60） and serum Cystatin C （n=39） at following 5 intervals： before operation （TO）, 20 minutes before anhepatic phase （T1）, 25 minutes in anhepatic （T2）, 60 minutes after reperfusion （T3） and at the end of operation（T4）. Urinary B2 MG （n=60） and NAG （n=60） were also examined at following 3 intervals： before operation （TO）, 60 minutes after reperfusion （T3） and at the end of operation （T4）. According to the Rimola A criteria of ARF in 24 hours after operation, all the patients were divided into two groups： ARF group and non-ARF group. The data were statistically analyzed to evaluate the feasibiliy of regarding these factors as prognostic factors for early ARF after liver transplantation in patients with normal SCr and BUN before operation. Results Ten of sixty cases showed ARF（16.7%）. The Logistic regression analysis showed that the levels of serum and urinary β2 MG as well as serum cystatin C before operation were correlated with early ARF after liver transplantation （P 〈0.05）, while only serum levels of cystatin C and Cr at the end of operation c

关键词： liver transplantation acute renal failure cystatin C β2-microglobulin

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