Prophylaxis and Therapy of Isaria felina on Acute Renal Failure Induced by Glycerin in Rats

作     者：YANG Xi-hua2,3,ZHANG Sheng-wan1,REN Lian-sheng3,BAI Xi-hua3 1.College of Life Science,Shanxi University,Taiyuan 030006,China 2.College of Chemistry and Chemical Engineering,Shanxi University,Taiyuan 030006,China 3.Department of Comparative Medicine,Shanxi Cancer Institute,Taiyuan 030013,China 

作者机构：College of Chemistry and Chemical Engineering Shanxi University Taiyuan 030006 China Department of Comparative Medicine Shanxi Cancer Institute Taiyuan 030013 China College of Life Science Shanxi University Taiyuan 030006 China 

出 版 物：《Chinese Herbal Medicines》 (中草药（英文版）)

年 卷 期：2012年第4卷第4期

页      面：319-323页

学科分类：1007[医学-药学(可授医学、理学学位)] 1005[医学-中医学] 1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

主　　题：acute renal failure blood urea nitrogen glycerin Isaria felina serum creatinine 

摘      要：Objective To evaluate the prophylaxis and therapy of Isaria felina(IF) on glycerin-induced acute renal failure(ARF) in *** Forty male Wistar rats were divided into control,model,Uremic Clearance Granule(UCG,positive control),high-and low-dose IF *** in the high-and low-dose IF groups were ig administered with 200 and 100 mg/kg IF,respectively,while rats were ig administered with 3.6 g/kg UCG successively for 7 d to establish UCG *** rats in model,control,and drug-treated groups were im injected with 8 mL/kg 50% glycerin after drinking was quitted for 24 h to induce ARF in *** drugs were continued to give *** level of blood urea nitrogen(BUN) and serum creatinine(SCr) were determined 24 and 72 h after the injection of glycerin,also the kidney was dissected for pathology *** Im injection with 8 mL/kg 50% glycerin could successfully induce ARF in *** dose of 200 mg/kg IF could reduce the high levels of BUN and SCr,and ameliorate the pathological damage of the *** IF has good protective and therapeutic effects on ARF and it is a potential and valuable Chinese herb for ARF.