Vancomycin dosing in an obese patient with acute renal failure:A case report and review of literature
作者机构：Department of PharmacyFourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina Department of Intensive Care UnitFourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina
出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)
年 卷 期：2022年第10卷第18期
页 面：6218-6226页
核心收录：
学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：Supported by the Hebei Natural Science Foundation of China No.H2019206614
主 题：Vancomycin Obesity Acute renal failure Pharmacokinetics Case report
摘 要：BACKGROUND Vancomycin is the most commonly used drug for methicillin-resistant Staphylococcus *** empirical clinical doses of vancomycin based on non-obese patients may not be optimal for obese *** SUMMARY This study reports a case of vancomycin dosing adjustment in an obese patient(body mass index 78.4 kg/m2)with necrotizing fasciitis of the scrotum and left lower extremity accompanied with acute renal *** adjustment was performed based on literature review and factors that influence pharmacokinetic parameters are *** results of the blood drug concentration monitoring confirmed the successful application of our dosing adjustment strategy in this obese *** body weight is an important consideration for vancomycin administration in obese patients,which affects the volume of distribution and clearance of *** alterations of pharmacokinetic parameters dictate that vancomycin should be dose-adjusted when applied to obese *** the same time,the pathophysiological status of patients,such as renal function,which also affects the dose adjustment of the patient,should be *** Monitoring vancomycin blood levels in obese patients is critical to help adjust the dosing regimen to ensure that vancomycin concentrations are within the effective therapeutic range and to reduce the incidence of renal injury.
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