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Neural Regeneration Research 2011年第25期6卷 1965-1970页

作者： Daxing Wu Ying Zhao Jian Liao Huifang Yin Wei Wang Medical Psychological Research Institute Second Xiangya Hospital of Central South University Changsha 410011 Hunan Province China Department of Radiology Third Xiangya Hospital of Central South University Changsha 410013 Hunan Provionce China

voxel-based morphometry-diffeomorphic anatomical registration using exponentiated lie algebra analysis was used to investigate the structural characteristics of white matter in young males with antisocial personality disorder （APD） and healthy controls without APD. The results revealed that APD subjects, relative to healthy subjects, exhibited increased white matter volume in the bilateral prefrontal lobe, right insula, precentral gyrus, bilateral superior temporal gyrus, right postcentral gyrus, right inferior parietal Iobule, right precuneus, right middle occipital lobe, right parahippocampal gyrus and bilateral cingulate, and decreased volume in the middle temporal cortex and right cerebellum. The white matter volume in the medial frontal gyrus was significantly correlated with antisocial type scores on the Personality Diagnostic Questionnaire in APD subjects. These experimental findings indicate that white matter abnormalities in several brain areas may contribute to antisocial behaviors in APD subjects.

关键词： white matter frontal lobe antisocial personality disorder voxel-based morphometry neuroimaging

Regional brain structural abnormality in ischemic stroke patients:a voxel-based morphometry study

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Neural Regeneration Research 2016年第9期11卷 1424-1430页

作者： Ping Wu Yu-mei Zhou Fang Zeng Zheng-jie Li Lu Luo Yong-xin Li Wei Fan Li-hua Qiu Wei Qin Lin Chen Lin Bai Juan Nie San Zhang Yan Xiong Yu Bai Can-xin Yin Fan-rong Liang Acupuncture and Tuina School/Third Teaching Hospital Chengdu University of Traditional Chinese Medicine China Academy of Chinese Medical Sciences World Federation of Acupuncture-Moxibustion Societies Institute of Clinical Anatomy School of Basic Medical SciencesSouthern Medical University Radiology Department West China Hospital of Sichuan University Life Sciences Research Center School of Life Sciences and TechnologyXidian University

Our previous study used regional homogeneity analysis and found that activity in some brain areas of patients with ischemic stroke changed significantly. In the current study, we examined structural changes in these brain regions by taking structural magnetic resonance imaging scans of 11 ischemic stroke patients and 15 healthy participants, and analyzing the data using voxel-based morphometry. Compared with healthy participants, patients exhibited higher gray matter density in the left inferior occipital gyrus and right anterior white matter tract. In contrast, gray matter density in the right cerebellum, left precentral gyrus, right middle frontal gyrus, and left middle temporal gyrus was less in ischemic stroke patients. The changes of gray matter density in the middle frontal gyrus were negatively associated with the clin- ical rating scales of the Fugl-Meyer Motor Assessment （r = -0.609, P = 0.047） and the left middle temporal gyrus was negatively correlated with the clinical rating scales of the nervous functional deficiency scale （r = -0.737, P = 0.010）. Our findings call objectively identify the functional abnormality in some brain regions of ischemic stroke patients.

关键词： nerve regeneration ischemic stroke brain structure abnormality Junctional magnetic resonance imaging gray matter density voxel-based morphometry Fugl-Meyer Motor Assessment nervous fi^nctional deficiency scale functional deficiency neuroplasticity neuralreorganization neural regeneration

Brain structure in post-traumatic stress disorder A voxel-based morphometry analysis

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Neural Regeneration Research 2013年第26期8卷 2405-2414页

作者： Liwen Tan Li Zhang Rongfeng Qi Guangming Lu Lingjiang Li Jun Liu Weihui Li Mental Health Institute of the Second Xiangya Hospital Central South UniversityKey Laboratory of Psychiatry and Mental Health of Hunan Province Hunan Province Technology Institute of Psychiatry Department of Medical Imaging Jinling Hospital Clinical School of Medical College Nanjing University Department of Radiology the Second Xiangya Hosipital Central South University School of Public Administration Central South University

This study compared the difference in brain structure in 12 mine disaster survivors with chronic post-traumatic stress disorder, 7 cases of improved post-traumatic stress disorder symptoms, and 14 controls who experienced the same mine disaster but did not suffer post-traumatic stress disorder, using the voxel-based morphometry method. The correlation between differences in brain structure and post-traumatic stress disorder symptoms was also investigated. Results showed that the gray matter volume was the highest in the trauma control group, followed by the symptoms-improved group, and the lowest in the chronic post-traumatic stress disorder group. Compared with the symptoms-improved group, the gray matter volume in the lingual gyrus of the right occipital lobe was reduced in the chronic post-traumatic stress disorder group. Compared with the trauma control group, the gray matter volume in the right middle occipital gyrus and left middle frontal gyrus was reduced in the symptoms-improved group. Compared with the trauma control group, the gray matter volume in the left superior parietal lo- bule and right superior frontal gyrus was reduced in the chronic post-traumatic stress disorder group. The gray matter volume in the left superior parietal Iobule was significantly positively correlated with the State-Trait Anxiety Inventory subscale score in the symptoms-improved group and chronic post-traumatic stress disorder group （r = 0.477, P = 0.039）. Our findings indicate that （1） chronic post-traumatic stress disorder patients have gray matter structural damage in the prefrontal lobe, oc- cipital lobe, and parietal lobe, （2） after post-traumatic stress, the disorder symptoms are improved and gray matter structural damage is reduced, but cannot recover to the trauma-control level, and （3） the superior parietal Iobule is possibly associated with chronic post-traumatic stress disorder. Post-traumatic stress disorder patients exhibit gray matter abnormalities.

关键词： neural regeneration neuroimaging MRI post-traumatic stress disorder voxel-based morphometry pre-frontal lobe parietal lobe occipital lobe follow-ups grants-supported paper neuroregeneration

Brain structure in diving players on MR imaging studied with voxel-based morphometry

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Progress in Natural Science:Materials International 2009年第10期19卷 1397-1402页

作者： Gaoxia Wei a,Jing Luo a,Youfa Lib a Key Laboratory of Mental Health,Institute of Psychology,Chinese Academy of Sciences,Beijing 100101,China b National Key Laboratory of Cognitive Neurosciences and Learning,Beijing Normal University,Beijing 100875,China Key Laboratory of Mental Health Institute of Psychology Chinese Academy of Sciences Beijing 100101 China National Key Laboratory of Cognitive Neurosciences and Learning Beijing Normal University Beijing 100875 China

We adopted professional diving players as a typical subject pool to explore whether structural brain differences relative to motor skill acquisition exist between highly skilled athletes and *** on the voxel-based morphometric(VBM) technique,structural MRIs of the brains of 12 elite diving players with professional training were analyzed and compared with those of control subjects without any professional physical *** players showed significantly increased gray matter density in the thalamus and left pre-central gyrus than control ***,future researches are needed to prove the contribution of preposition and *** also suggests that athletes as the subject pool could form a new subject pool to explore plastic change induced by motor skill acquisition.

关键词： Cortical plasticity Motor skill acquisition voxel-based morphometry Diving players

Volume Gain of Brainstem on Medication-Overuse Headache Using voxel-based morphometry

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Chinese Medical Journal 2018年第18期131卷 2158-2163页

作者： Zhioye Chen Xiao-Yan Chen Meng-Qi Liu Lin Ma Sheng-Yuan Yu Department of Radiology Chinese People's Liberation Army General Hospital Beijing 100853 China Department of Radiology Hainan Branch of Chinese People's Liberation Army General Hospital Sanya Hainan 572013 China Department of Neurology Chinese People's Liberation Army General Hospital Beijing 100853 China

Background： Histopathology identified the anatomical and molecular abnormalities ofbrainstem nuclei in migraine patients. However, the exact whole brainstem structural changes in vivo have not yet been identified in medication-overuse headache （MOH） transformed from migraine. The aim of this study was to investigate the regional volume changes over the whole brainstem in the MOH patients using voxel-based morphometry （VBM） in ***： High-resolution three-dimensional structural images were obtained using a 3.0-Tesla magnetic resonance system from 36 MOH patients and 32 normal controls （NCs） who were consecutively recruited from the International Headache Center, Chinese People＇s Liberation Army General Hospital, from March 2013 to June 2016. VBM was used to assess the brainstem structural alteration in the MOH patients, and voxel-wise correlation was performed to evaluate the relationship with the clinical ***： The brainstem region with increased volume located in the left ventrolateral periaqueductal gray （MNI coordinate： -1, -33, -8）, ventral tegmental area （MNI coordinate： 0, -22, - 12）, bilateral substantia nigra （MNI coordinate： -8, - 16, - 12, 9, - 16, - 12）, and trigeminal root entry zone （MNI coordinate： -19, -29, -31; 19, -32, -29） in MOH patients compared with NCs. The headache visual analog scale score was positively related with the left rostral ventromedial medulla （RVM）（MNI coordinate： -1, -37, -56; cluster size： 20; r = 0.602） in the MOH ***： The regional volume gain ofbrainstem could underlie the neuromechanism of impaired ascending and descending pathway in the MOH patients, and the left RVM volume alteration could imply the impaired tolerance ofnociceptive pain input and could be used to assess the headache disability in the MOH patients.

关键词： Medication-Overuse Headache Substantia Nigra Trigeminal Root Entry Zone Ventral Tegmental Area voxel-based morphometry

Brain expansion in patients with type Ⅱ diabetes following insulin therapy:a preliminary study with longitudinal voxel-based morphometry

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Brain expansion in patients with type Ⅱ diabetes following ...

Changes of brain gray matter structure in Parkinson's disease patients with dementia

中国神经科学学会第十届全国学术会议

作者： Zhiye Chen Mengyu Liu Jie Sun Shengyu Yu Lin Ma Department of Radiology Chinese PLA General Hospital Department of Endocrinology Chinese PLA General Hospital Department of Neurology Chinese PLA General Hospital

Objective We performed a longitudinal analysis based on MR imaging to investigate the brain structural and perfusion changes caused by insulin therapy in patients with type Ⅱ *** High resolution three-dimensional T1-weighted fast spoiled gradient recalled echo images and flow-sensitive alternating inversion recovery（FAIR） images were obtained from 11 patients with type Ⅱ diabetes before and one year after initiation of insulin therapy and 11 normal *** volume changes were investigated by a longitudinal voxel-based morphometry,and perfusion changes were evaluated by FAIR imaging between baseline and follow-up *** Significant regional gray matter expansion located in bilateral frontal,parietal,and left occipital lobes,and regional white matter expansion was shown in left precentral subcortical white matter and right angular subcortical white matter after insulin therapy（P ＜ 0.05 with FDR correction）.Brain hyperperfusion was detected in bilateral frontal cortex,left occipital cortex,and right temporal cortex after insulin therapy（P ＜ 0.05）.Conclusions In patients with type Ⅱ diabetes,brain expansion and hyperperfusion were demonstrated one year after initiation of insulin therapy,and insulin therapy could contribute to the brain volume gainment in the patients with type Ⅱ diabetes.

关键词： type Ⅱ diabetes insulin voxel-based morphometry brain MRI

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Neural Regeneration Research 2013年第14期8卷 1276-1285页

作者： Jianguo Xia Jinlin Miu Hongbin Ding Xiuping Wang Hua Chen Juan Wang Juan Wu Jingli Zhao Huanxin Huang Weizhong Tian Department of Radiology Taizhou People's Hospital Department of Radiology the Fourth People's Hospital of Taizhou Department of Medical Image Engineering Medical School of Nantong University Department of Radiology Affiliated Hospital of Nantong University Department of Geriatrics Affiliated Hospital of Nantong University

voxel-based morphometry is gaining considerable interest for studies examining Parkinson＇s disease dementia patients. In this study, 12 patients with clinically defined Parkinson＇s disease and dementia and 12 non-demented patients with Parkinson＇s disease were examined using a T1WI three-dimensional fast spoiled gradient echo sequence. Gray matter data were analyzed using a voxel-based morphometry method and independent sample t-test based on Statistical Parametric Mapping 5 software. Differences in gray matter volume were represented with statistical parametric mapping. Compared with Parkinson＇s disease patients without dementia, decreased gray matter volume in Parkinson＇s disease dementia patients was observed in the bilateral superior temporal gyrus, bilateral posterior cingulate and left cingulate gyrus, right parahippocampal gyrus and hippocampus, right precuneus and right cuneus, left inferior frontal gyrus and left insular lobe. No increased gray matter volume was apparent. These data indicate that gray matter atrophy in the limbic system and cerebral neocortex is related to the presence of dementia.

关键词： neural regeneration neurodegenerative diseases neuroimaging voxel-based morphometry Parkinson's disease dementia gray matter abnormality limbic system grants-supported paper neuroregeneration

A Systematic Characterization of Structural Brain Changes in Schizophrenia

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Neuroscience Bulletin 2020年第10期36卷 1107-1122页

作者： Wasana Ediri Arachchi Yanmin Peng Xi Zhang Wen Qin Chuanjun Zhuo Chunshui Yu Meng Liang School of Medical Imaging and Tianjin Key Laboratory of Functional Imaging Tianjin Medical UniversityTianjin 300203China Department of Radiography and Radiotherapy Faculty of Allied Health SciencesGeneral Sir John Kotelawala Defence UniversityRatmalana 10390Sri Lanka Department of Radiology and Tianjin Key Laboratory of Functional Imaging Tianjin Medical University General HospitalTianjin 300052China Department of Psychiatric-Neuroimaging-Genetics and Comorbidity Laboratory Tianjin Mental Health CenterTianjin Anding HospitalTianjin 300222China CAS Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghai 200031China

A systematic characterization of the similarities and differences among different methods for detecting structural brain abnormalities in schizophrenia,such as voxel-based morphometry(VBM),tensor-based morphometry(TBM),and projection-based thickness(PBT),is important for understanding the brain pathology in schizophrenia and for developing effective biomarkers for a diagnosis of ***,such studies are still ***,we performed VBM,TBM,and PBT analyses on T1-weighted brain MR images acquired from 116 patients with schizophrenia and 116 healthy *** found that,although all methods detected wide-spread structural changes,different methods captured different information-only 10.35%of the grey matter changes in cortex were detected by all three methods,and VBM only detected 11.36%of the white matter changes detected by ***,pattern classification between patients and controls revealed that combining different measures improved the classification accuracy(81.9%),indicating that fusion of different structural measures serves as a better neuroimaging marker for the objective diagnosis of schizophrenia.

关键词： voxel-based morphometry Tensor-based morphometry Deformation-based morphometry Cortical thickness Multivariate pattern analysis Structural MRI Schizophrenia

Magnetic resonance imaging based volumetry:a primary approach to unravelling the brain

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Progress in Natural Science:Materials International 2007年第7期17卷 751-760页

作者： Huang Xiaoqi~(1,2) LüSu~1 Li Dongming~1 Gong Qiyong~(1,3**) (1.Huaxi MR Research Centre(HMRRC),and Department of Radiology,West China Hospital/West China School of Medicine,Chengdu 610041,China 2.Department of Psychiatry,West China Hospital/West China School of Medicine,Chengdu 610041,China 3.Division of Medical Imaging,Faculty of Medicine,University of Liverpool,United Kingdom) Huaxi MR Research Centre (HMRRC) Department of Radiology West China Hospital/West China School of Medicine Chengdu 610041 China Department of Psychiatry West China Hospital/West China School of Medicine Chengdu 610041 China Division of Medical Imaging Faculty of Medicine University of Liverpool United Kingdom United Kingdom

Magnetic resonance(MR)imaging based volumetry is recognized as an important technique for studying the *** this review,two principle volumetric methods using high resolution MR images were introduced,namely the Cavalieri method and the voxel based morphometry(VBM).The Cavalieri method represents a manual technique that allows the volume of brain structures to be estimated efficiently with no systematic error or sampling bias,whereby the VBM represents an automated image analysis which involves the use of statistical parametric mapping of the MR imaging *** methods have been refined and applied extensively in recent neuro- science *** present paper aims to describe the development of methodologies and also to update the knowledge of their applica- tions in studying the normal and diseased brain.

关键词： MR imaging Cavalieri method voxel-based morphometry brain volumetry

Joint Multi-modal Parcellation of the Human Striatum:Functions and Clinical Relevance

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Neuroscience Bulletin 2020年第10期36卷 1123-1136页

作者： Xiaojin Liu Simon B.Eickhoff Felix Hoffstaedter Sarah Genon Svenja Caspers Kathrin Reetz Imis Dogan Claudia R.Eickhoff Ji Chen Julian Caspers Niels Reuter Christian Mathys Andre Aleman Renaud Jardri Valentin Riedl Iris E.Sommer Kaustubh R.Patil Institute of Neuroscience and Medicine(INM-7 Brain and Behaviour)Research Centre JiilichJiilichGermany Institute of Systems Neuroscience Heinrich Heine University DusseldorfDusseldorfGermany Institute of Neuroscience and Medicine(INM-1) Research Centre Jiilich52428 JiilichGermany Institute for Anatomy I Medical FacultyHeinrich Heine University Dusseldorf40225 DusseldorfGermany Jiilich Aachen Research Alliance-BRAIN(JARA)Institute of Molecular Neuroscience and Neuroimaging Forschungszentrum JiilichRheinisch Westfallische Technische Hochschule(RWTH)Aachen University52074 AachenGermany Department of Neurology Rheinisch Westfallische Technische Hochschule(RWTH)Aachen University52074 AachenGermany Institute of Clinical Neuroscience and Medical Psychology Medical FacultyUniversity of Dusseldorf40225 DusseldorfGermany Department of Diagnostic and Interventional Radiology Medical FacultyUniversity of Dusseldorf40225 DusseldorfGermany Institute of Radiology and Neuroradiology Evangelisches KrankenhausUniversity of Oldenburg26129 OldenburgGermany Department of Neuroscience University Medical Center GroningenUniversity of Groningen9713 AV GroningenThe Netherlands SCALab(CNRS UMR9193)&CHU de LiUe Hopital FontanPole de Psychiatrie(CURE)Universite de Lille59037 LilleFrance Departments of Neuroradiology Nuclear Medicine and Neuroimaging CenterTechnische Universitat Miinchen80333 MunichGermany

The human striatum is essential for both lowand high-level functions and has been implicated in the pathophysiology of various prevalent disorders,including Parkinson's disease(PD)and schizophrenia(SCZ).It is known to consist of structurally and functionally divergent ***,previous parcellations are based on a single neuroimaging modality,leaving the extent of the multi-modal organization of the striatum ***,we investigated the organization of the striatum across three modalities—resting-state functional connectivity,probabilistic diffusion tractography,and structural covariance—to provide a holistic convergent view of its structure and *** found convergent clusters in the dorsal,dorsolateral,rostral,ventral,and caudal *** characterization revealed the anterior striatum to be mainly associated with cognitive and emotional functions,while the caudal striatum was related to action ***,significant structural atrophy in the rostral and ventral striatum was common to both PD and SCZ,but atrophy in the dorsolateral striatum was specifically attributable to *** study revealed a cross-modal convergent organization of the striatum,representing a fundamental topographical model that can be useful for investigating structural and functional variability in aging and in clinical conditions.

关键词： Striatum Multi-modal Connectivity-based parcellation Convergent clusters voxel-based morphometry Parkinson's disease Schizophrenia