A Systematic Characterization of Structural Brain Changes in Schizophrenia

作     者：Wasana Ediri Arachchi Yanmin Peng Xi Zhang Wen Qin Chuanjun Zhuo Chunshui Yu Meng Liang Wasana Ediri Arachchi;Yanmin Peng;Xi Zhang;Wen Qin;Chuanjun Zhuo;Chunshui Yu;Meng Liang

作者机构：School of Medical Imaging and Tianjin Key Laboratory of Functional ImagingTianjin Medical UniversityTianjin 300203China Department of Radiography and RadiotherapyFaculty of Allied Health SciencesGeneral Sir John Kotelawala Defence UniversityRatmalana 10390Sri Lanka Department of Radiology and Tianjin Key Laboratory of Functional ImagingTianjin Medical University General HospitalTianjin 300052China Department of Psychiatric-Neuroimaging-Genetics and Comorbidity LaboratoryTianjin Mental Health CenterTianjin Anding HospitalTianjin 300222China CAS Center for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai 200031China 

出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)

年 卷 期：2020年第36卷第10期

页      面：1107-1122页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100205[医学-精神病与精神卫生学] 10[医学] 

基　　金：This work was supported by the National Key Research and Development Program of China(2017 YFC0909201 and 2018YFC1314300) the National Natural Science Foundation of China(81571659,81971694,81971599,81771818,81425013,and 81871052) and the Tianjin Key Technology R&D Program(17ZXMFSY00090) 

主　　题：Voxel-based morphometry Tensor-based morphometry Deformation-based morphometry Cortical thickness Multivariate pattern analysis Structural MRI Schizophrenia 

摘      要：A systematic characterization of the similarities and differences among different methods for detecting structural brain abnormalities in schizophrenia,such as voxel-based morphometry(VBM),tensor-based morphometry(TBM),and projection-based thickness(PBT),is important for understanding the brain pathology in schizophrenia and for developing effective biomarkers for a diagnosis of ***,such studies are still ***,we performed VBM,TBM,and PBT analyses on T1-weighted brain MR images acquired from 116 patients with schizophrenia and 116 healthy *** found that,although all methods detected wide-spread structural changes,different methods captured different information-only 10.35%of the grey matter changes in cortex were detected by all three methods,and VBM only detected 11.36%of the white matter changes detected by ***,pattern classification between patients and controls revealed that combining different measures improved the classification accuracy(81.9%),indicating that fusion of different structural measures serves as a better neuroimaging marker for the objective diagnosis of schizophrenia.