Brain expansion in patients with type Ⅱ diabetes following insulin therapy:a preliminary study with longitudinal voxel-based morphometry
作者单位：Department of RadiologyChinese PLA General Hospital Department of EndocrinologyChinese PLA General Hospital Department of NeurologyChinese PLA General Hospital
会议名称：《中国神经科学学会第十届全国学术会议》
会议日期：2013年
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
关 键 词：type Ⅱ diabetes insulin voxel-based morphometry brain MRI
摘 要：Objective We performed a longitudinal analysis based on MR imaging to investigate the brain structural and perfusion changes caused by insulin therapy in patients with type Ⅱ *** High resolution three-dimensional T1-weighted fast spoiled gradient recalled echo images and flow-sensitive alternating inversion recovery（FAIR） images were obtained from 11 patients with type Ⅱ diabetes before and one year after initiation of insulin therapy and 11 normal *** volume changes were investigated by a longitudinal voxel-based morphometry,and perfusion changes were evaluated by FAIR imaging between baseline and follow-up *** Significant regional gray matter expansion located in bilateral frontal,parietal,and left occipital lobes,and regional white matter expansion was shown in left precentral subcortical white matter and right angular subcortical white matter after insulin therapy（P 0.05 with FDR correction）.Brain hyperperfusion was detected in bilateral frontal cortex,left occipital cortex,and right temporal cortex after insulin therapy（P 0.05）.Conclusions In patients with type Ⅱ diabetes,brain expansion and hyperperfusion were demonstrated one year after initiation of insulin therapy,and insulin therapy could contribute to the brain volume gainment in the patients with type Ⅱ diabetes.