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vitamin b2 functionalized iron oxide nanozymes for mouth ulcer healing

Science China(Life Sciences) 2020年第1期63卷 68-79页

作者： Yunhao Gu Yixin Huang Zhiyue Qiu Zhuobin Xu Dandan Li Lei Chen Jing Jiang Lizeng Gao Institute of Translational Medicine Department of PharmacologySchool of MedicineYangzhou UniversityYangzhou 225001China Jiangsu Key Laboratory of Experimental and Translational Non-coding RNA Research Yangzhou UniversityYangzhou 225001China

Mouth ulcer is associated with inflammation and high risk of bacterial infection, which aggravates the patient's ***, there is no effective treatment for mouth ulcer. Herein, we report that vitamin-modified iron oxide nanoparticles improve the healing of mouth ulcer through anti-inflammation and antibacterial activities. We discovered that vitamin b2(Vb2)modified iron oxide nanoparticles performed enhanced peroxidase-like, catalase-like, and superoxide dismutase(SOD)-like activities, acting as typical iron oxide nanozymes(IONzymes) with triad activities. In particular, Vb2 modification significantly improved the SOD-like activity, thus providing a reactive oxygen species(ROS)-scavenging ability. Cellular antioxidant experiments showed that vitamin b2 modified IONzymes(Vb2-IONzymes) protect human oral keratinocytes(HOK) and bALb/3 T3 cells from hydrogen peroxide(H2O2), and these cells have high biocompatibility to eukaryotic cells. In addition, Vb2-IONzymes exerted an antibacterial activity against Streptococcus mutans, Staphylococcus aureus, and Escherichia coli. Importantly, Vb2-IONzymes accelerated the recovery of mouth ulcer and reduced the local secretion of inflammatory factors in mouse ulcer model via ROS scavenging and antibacterial activity. Taken together, our work demonstrates that vitamin b2 modification endows iron oxide nanoparticles with enhanced enzyme-like activities and Vb2-IONzymes may be a promising reagent in the treatment of mouth ulcer because of their intrinsic anti-inflammation and antibacterial capabilities.

关键词： iron oxide nanozymes vitamin b2 ROS scavenging mouth ulcer anti-inflammation

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Genome-wide association mapping of vitamins b1 and b2 in common wheat

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The Crop Journal 2018年第3期6卷 263-270页

作者： Jieyun Li Jindong Liu Wei'e Wen Pingzhi Zhang Yingxiu Wan Xianchun Xia Yan Zhang Zhonghu He Institute of Crop Science National Wheat Improvement CenterChinese Academy of Agricultural SciencesBeijing 100081China International Maize and Wheat Improvement Center(CIMMYT)China Office c/o CAASBeijing 100081China Crop Research Institute Anhui Academy of Agricultural SciencesHefei 230001AnhuiChina

vitamin b is essential for maintaining normal life activities in humans and animals who have to intake the microelement from the outside, especially from cereal products. In the present study 166 Chinese and foreign wheat cultivars planted in two environments were characterized for variation in vitamin b1 and b2 contents. A genome-wide association study(GWAS) using the wheat 90 K SNP assay identified 17 loci for vitamin b1 and 7 for vitamin b2 contents. Linear regression analysis showed a significantly positive correlation of the number of favorable alleles with vitamin b1 and b2 contents. Marker-trait associations(MTAs) at IWb43809(6AS, 0cM) and IWb69903(6AS, 13cM) were new and stable, and significantly associated with vitamin b1 content across two environments. The loci identified in this study and associated SNP markers could be used for improvement of vitamin b1 and b2 contents to obtain superior quality along with grain yield in wheat.

关键词： 90 K SNP assay GWAS vitamin b1 vitamin b2 Triticum aestivum

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Impact of increasing one-carbon metabolites on traumatic brain injury outcome using pre-clinical models

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Neural Regeneration Research 2024年第8期19卷 1728-1733页

作者： Sanika M.Joshi Theresa Currier Thomas Nafisa M.Jadavji College of Osteopathic Medicine Midwestern UniversityGlendaleCAUSA Department of biomedical Sciences Midwestern UniversityGlendaleCAUSA Department of Child Health College of Medicine–PhoenixUniversity of ArizonaPhoenixAZUSA College of Veterinary Medicine Midwestern UniversityGlendaleCAUSA Department of Neuroscience Carleton UniversityOttawaCanada

Traumatic brain injury is a major cause of death and disability worldwide,affecting over 69 million individuals ***-carbon metabolism has been shown to have beneficial effects after brain damage,such as ischemic ***,whether increasing one-carbon metabolite vitamins impacts traumatic brain injury outcomes in patients requires more *** aim of this review is to evaluate how one-carbon metabolites impact outcomes after the onset of traumatic brain ***,Web of Science,and Google Scholar databases were searched for studies that examined the impact of b-vitamin supplementation on traumatic brain injury *** search terms included combinations of the following words:traumatic brain injury,dietary supplementation,one-carbon metabolism,and *** focus of each literature search was basic science *** year of publication in the literature searches was not *** analysis of the literature has shown that dietary supplementation of b-vitamins has significantly improved the functional and behavioral recove ry of animals with traumatic brain injury compared to *** r,this improvement is dosage-dependent and is contingent upon the onset of supplementation and whether there is a sustained or continuous delive ry of vitamin supplementation post-traumatic brain *** details of supplementation post-traumatic brain injury need to be further ***,we conclude that b-vitamin supplementation improves behavioral outcomes and reduces cognitive impairment post-traumatic brain injury in animal model *** investigation in a clinical setting should be stro ngly considered in co njunction with current medical treatments for traumatic brain injury-affected individuals.

关键词： folic acid nicotinamide one-carbon metabolism riboflavin traumatic brain injury vitamin b12 vitamin b2 vitamin b3

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