Impact of increasing one-carbon metabolites on traumatic brain injury outcome using pre-clinical models

作     者：Sanika M.Joshi Theresa Currier Thomas Nafisa M.Jadavji Sanika M.Joshi;Theresa Currier Thomas;Nafisa M.Jadavji

作者机构：College of Osteopathic MedicineMidwestern UniversityGlendaleCAUSA Department of Biomedical SciencesMidwestern UniversityGlendaleCAUSA Department of Child HealthCollege of Medicine–PhoenixUniversity of ArizonaPhoenixAZUSA College of Veterinary MedicineMidwestern UniversityGlendaleCAUSA Department of NeuroscienceCarleton UniversityOttawaCanada 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2024年第19卷第8期

页      面：1728-1733页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：Salary for TCT was supported by National Institutes of Health Grant(R01NS100793) 

主　　题：folic acid nicotinamide one-carbon metabolism riboflavin traumatic brain injury vitamin B12 vitamin B2 vitamin B3 

摘      要：Traumatic brain injury is a major cause of death and disability worldwide,affecting over 69 million individuals ***-carbon metabolism has been shown to have beneficial effects after brain damage,such as ischemic ***,whether increasing one-carbon metabolite vitamins impacts traumatic brain injury outcomes in patients requires more *** aim of this review is to evaluate how one-carbon metabolites impact outcomes after the onset of traumatic brain ***,Web of Science,and Google Scholar databases were searched for studies that examined the impact of B-vitamin supplementation on traumatic brain injury *** search terms included combinations of the following words:traumatic brain injury,dietary supplementation,one-carbon metabolism,and *** focus of each literature search was basic science *** year of publication in the literature searches was not *** analysis of the literature has shown that dietary supplementation of B-vitamins has significantly improved the functional and behavioral recove ry of animals with traumatic brain injury compared to *** r,this improvement is dosage-dependent and is contingent upon the onset of supplementation and whether there is a sustained or continuous delive ry of vitamin supplementation post-traumatic brain *** details of supplementation post-traumatic brain injury need to be further ***,we conclude that B-vitamin supplementation improves behavioral outcomes and reduces cognitive impairment post-traumatic brain injury in animal model *** investigation in a clinical setting should be stro ngly considered in co njunction with current medical treatments for traumatic brain injury-affected individuals.