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Metabolic dysfunction-associated steatotic liver disease and type 2 diabetes:A dual threat to cardiac dysfunction progression

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World Journal of Cardiology 2025年第1期17卷 118-120页

作者： Wei Wang Charlie Cooper Chronic Disease and Health Management Research Center Geriatric Hospital of Nanjing Medical UniversityNanjing 210024Jiangsu ProvinceChina

Metabolic dysfunction-associated steatotic liver disease(MASLD),particularly in patients with type 2 diabetes mellitus(T2DM),is increasingly recognized as a multi-system disease that affects both hepatic and cardiovascular *** study explores the association between MASLD-related liver fibrosis and cardiac dysfunction,focusing on how liver fibrosis contributes to cardiac remodeling and *** et al’s research highlights the strong correlation between liver fibrosis and changes in left ventricular mass,left atrial dimensions,and systolic and diastolic function in diabetic ***,the study suggests a protective role of sex-hormone binding protein against cardiac *** findings underline the importance of early detection of liver fibrosis using noninvasive markers like fibrosis-4 index and nonalcoholic fatty liver disease fibrosis scores,which may offer dual protection for both liver and heart health in T2DM ***,this study calls for further research into the shared pathogenic mechanisms,including inflammation and fibrosis pathways,between the liver and *** advocates for the integration of liver fibrosis screening into cardiovascular risk management,urging clinicians to adopt a more holistic approach in treating patients with MASLD and *** research has broad implications for preventing cardiovascular complications and improving outcomes in this highrisk population.

关键词： Metabolic dysfunction-associated steatotic liver disease type 2 diabetes Cardiac dysfunction Left ventricular mass Sex-hormone binding protein Fibrosis-4 index scores

Glycemic Control and diabetes Duration in Relation to Subsequent Myocardial Infarction among Patients with Coronary Heart Disease and type 2 diabetes

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Biomedical and Environmental Sciences 2025年第1期38卷 27-36页

作者： Furong Li Yan Dou Chunbao Mo Shuang Wang Jing Zheng Dongfeng Gu Fengchao Liang School of Public Health and Emergency Management Southern University of Science and TechnologySchool of MedicineShenzhen 518055GuangdongChina Shenzhen Key Laboratory of Cardiovascular Health and Precision Medicine Southern University of Science and TechnologyShenzhen 518055GuangdongChina Department of Epidemiology National Center for Cardiovascular DiseasesFuwai HospitalChinese Academy of Medical Sciences&Peking Union Medical College/National Center for Cardiovascular DiseasesBeijing 100037China Shenzhen Health Development Research and Data Management Center Shenzhen 518106GuangdongChina

Objective This study aimed to investigate the impact of glycemic control and diabetes duration on subsequent myocardial infarction(MI)in patients with both coronary heart disease(CHD)and type 2 diabetes(T2D).Methods We conducted a retrospective cohort study of 33,238 patients with both CHD and T2D in Shenzhen,*** were categorized into 6 groups based on baseline fasting plasma glucose(FPG)levels and diabetes duration(from the date of diabetes diagnosis to the baseline date)to examine their combined effects on subsequent *** proportional hazards regression models were used,with further stratification by age,sex,and comorbidities to assess potential *** Over a median follow-up of 2.4 years,2,110 patients experienced *** to those with optimal glycemic control(FPGdiabetes duration(diabetes duration of≥10 years and FPG>8.0 mmol/L was 1.93(95%CI:1.59,2.36).The combined effects of FPG and diabetes duration on MI were largely similar across different age,sex,and comorbidity groups,although the excess risk of MI associated with long-term diabetes appeared to be more pronounced among those with atrial *** Our study indicates that glycemic control and diabetes duration significant influence the subsequent occurrence of MI in patients with both CHD and *** management strategies emphasizing strict glycemic control may be particularly beneficial for patients with longer diabetes duration and atrial fibrillation.

关键词： Coronary heart disease type 2 diabetes Myocardial infarction diabetes duration Fasting plasma glucose

Clinical study on the effect of jejunoileal side-to-side anastomosis on metabolic parameters in patients with type 2 diabetes

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World Journal of diabetes 2025年第1期16卷 58-64页

作者： Ji-Kui Wang Di Zhang Jin-Feng Wang Wan-Lin Lu Jing-Yuan Wang Shi-Feng Liang Ran Liu Jing-Xin Jiang Hong-Tao Li Xuan Yang Department of General Thoracic Surgery Liaoning Electric Power Center HospitalShenyang 110000Liaoning ProvinceChina Department of Health Management Center Liaoning Electric Power Center HospitalShenyang 110000Liaoning ProvinceChina

BACKGROUND At present,the existing internal medicine drug treatment can alleviate the high glucose toxicity of patients to a certain extent,to explore the efficacy of laparoscopic jejunoileal side to side anastomosis in the treatment of type 2 diabetes,the report is as *** To investigate the effect of jejunoileal side-to-side anastomosis on metabolic parameters in patients with type 2 diabetes mellitus(T2DM).METHODS We retrospectively analyzed the clinical data of 78 patients with T2DM who were treated via jejunoileal lateral *** indicators were collected preoperatively,as well as at 3 and 6 months *** metabolic indicators analyzed included body mass index(BMI),systolic blood pressure(SBP),diastolic blood pressure(DBP),fasting blood glucose(FBG),2-hour blood glucose(PBG),glycated hemoglobin(HbA1c),fasting C-peptide,2-hour C-peptide(PCP),fasting insulin(Fins),2-hour insulin(Pins),insulin resistance index(HOMA-IR),βCellular function index(HOMA-β),alanine aminotransferase,aspartate aminotransferase,serum total cholesterol(TC),low-density lipoprotein cholesterol(L DL-C),triglycerides(TG),high-density lipoprotein,and uric acid(UA)*** SBP,DBP,PBG,HbA1c,LDL-C,and TG were all significantly lower 3 months postoperative vs preoperative values;body weight,BMI,SBP,DBP,FBG,PBG,HbA1c,TC,TG,UA,and HOMA-IR values were all significantly lower 6 months postoperative vs at 3 months;and PCP,Fins,Pins,and HOMA-βwere all significantly higher 6 months postoperative vs at 3 months(all P2DM and improve the metabolic index levels associated with it.

关键词： Metabolic diseases type 2 diabetes Jejunoileal side-to-side anastomosis Glycolipid metabolism Islet function

Impact of community public health care on treatment effect,health cognition,and self-management in patients with type 2 diabetes

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World Journal of Clinical Cases 2025年第5期13卷 22-29页

作者： Hong Shi Chun Liu Hong-Yan Luo Department of Infrastructure Operation West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Public Health Minzu Street Community Health Service CenterWuhan 430000Hubei ProvinceChina Caotang Community Health Service Center Chengdu 610031Sichuan ProvinceChina

BACKGROUND At present,China has become the country with the largest number of individuals with diabetes mellitus(DM)in the world,with a total of approximately 140 million patients,the majority of whom have type 2 DM(T2DM).Based on conven-tional nursing methods,community home care has important clinical significance in controlling blood sugar and disease *** To explore the impact of community public health nursing on treatment effect,health cognition,and self-management in patients with *** One hundred patients with T2DM were selected as the research *** patients were divided into either a conventional nursing group or community nursing(CN)group using the random number table *** conventional nursing group(50 cases)received routine care,while the CN group(50 cases)received community public health care in addition to routine care as that for the conventional nursing *** rate of excellent and good blood glucose control,fasting blood glucose before and after care,2-h postprandial blood glucose,health cognition,and self-management ability,and patient satisfaction were compared between the two *** The CN group had a higher rate of excellent blood sugar control than the conventional nursing group(88%vs 70%,P2-h postprandial blood glucose between the two groups of patients(P>0.05).After nursing,fasting blood glucose and 2-h postprandial blood glucose were reduced to varying degrees in both groups,and both blood glucose levels in the CN group were lower than those of the conventional nursing group(Pdiabetes and self-management ability score improved after care in both *** cognitive level and self-management ability of patients in the CN group were higher than those of the conventional nursing group(P<0.05).The overall satisfaction of the CN group was better than

关键词： Community public health care type 2 diabetes Blood sugar control Self-management ability Cognition level

Influence of gut bacteria on type 2 diabetes:Mechanisms and therapeutic strategy

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World Journal of diabetes 2025年第1期16卷 27-33页

作者： Xue Wen Lu-Ming Qi Kui Zhao College of Health and Rehabilitation Chengdu University of Traditional Chinese MedicineChengdu 610000Sichuan ProvinceChina College of Materials and Chemical Engineering Southwest Forestry UniversityKunming 650224Yunnan ProvinceChina

The onset and progression of type 2 diabetes mellitus(T2DM)are strongly associated with imbalances in gut bacteria,making the gut microbiome a new potential therapeutic *** commentary examines the recent publication in World Journal of *** article explores the association between T2DM and gut microbiota,with a focus on the pathophysiological changes related to *** proposes innovative microbiome-targeted therapeutic strategies and evaluates the challenges and future directions of such *** editorial summarizes the key points of their discussion of the role of the gut microbiome in T2DM and elaborates on the influence of specific gut microbial species on the disease through the host–microbiota metabolic *** provides new insights for future research on gut-microbiota-based interventions for T2DM.

关键词： type 2 diabetes Intestinal microbiome Intestinal axis Biological pathways Treatment Short-chain fatty acids

type 2 diabetes Risk Prediction Using Deep Convolutional Neural Network Based-Bayesian Optimization

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Computers, Materials & Continua 2023年第5期75卷 3223-3238页

作者： Alawi Alqushaibi Mohd Hilmi Hasan Said Jadid Abdulkadir Amgad Muneer Mohammed Gamal Qasem Al-Tashi Shakirah Mohd Taib Hitham Alhussian Computer&Information Sciences Universiti Teknologi PETRONASSeri Iskandar32610PerakMalaysia Centre for Research in Data Science(CERDAS) Universiti Teknologi PETRONASSeri Iskandar32610PerakMalaysia Department of Imaging Physics University of Texas MD Anderson CancerHoustonTXUSA

diabetes mellitus is a long-term condition characterized by *** could lead to plenty of *** to rising morbidity in recent years,the world’s diabetic patients will exceed 642 million by 2040,implying that one out of every ten persons will be *** is no doubt that this startling figure requires immediate attention from industry and academia to promote innovation and growth in diabetes risk prediction to save individuals’*** to its rapid development,deep learning(DL)was used to predict numerous ***,DLmethods still suffer from their limited prediction performance due to the hyperparameters selection and parameters ***,the selection of hyper-parameters is critical in improving classification *** study presents Convolutional Neural Network(CNN)that has achieved remarkable results in many medical domains where the Bayesian optimization algorithm(BOA)has been employed for hyperparameters selection and parameters *** issues have been investigated and solved during the experiment to enhance the *** first is the dataset class imbalance,which is solved using Synthetic Minority Oversampling Technique(SMOTE)*** second issue is the model’s poor performance,which has been solved using the Bayesian optimization *** findings indicate that the Bayesian based-CNN model superbases all the state-of-the-art models in the literature with an accuracy of 89.36%,F1-score of 0.88.6,andMatthews Correlation Coefficient(MCC)of 0.88.6.

关键词： type 2 diabetes diabetes mellitus convolutional neural network Bayesian optimization SMOTE

type 2diabetes is causally associated with depression: a Mendelian randomization analysis

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Frontiers of Medicine 2018年第6期12卷 678-687页

作者： Liping Xuan Zhiyun Zhao Xll Jia Yanan Hou Tiange Wang Mian Li Jieli Lu Yu Xu Yuhong Chen Lu Qi Weiqing Wang Yufang Bi Min Xu State Key Laboratory of Medical Genomics Key Laboratory for Endocrine and Metabolic Diseases of Ministry of HealthNational Clinical Research Center for Metabolic DiseasesCollaborative Innovation Center of Systems BiomedicineRuij'in Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai Institute of Endocrine and Metabolic Diseases Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Department of Endocrine and Metabolic Diseases Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Department of Epidemiology Tulane University School of Public Health and Tropical MedicineNew OrleansLA 70112USA

type 2 diabetes (T2D) has been associated with a high prevalence of *** aimed to determine the causal relation by performing a Mendelian randomization (MR) study using 34 T2D risk genetic variants validated in East Asians as the instrumental variable (IV). An MR analysis was performed involving 11 506 participants from a large longitudinal study. The T2D genetic risk score (GRS) was built using the 34 typical T2D common variants. We used T2D_GRS as the IV estimator and performed inverse-variance weighted (IVW) and Egger MR analysis. The T2D_GRS was found to be associated with depression with an OR of 1.21 (95% CI: 1.07–1.37) after adjustments for age, sex, body mass index, current smoking and drinking, physical activity, education, and marital status. Using T2D_GRS as the IV, we similarly found a causal relationship between genetically determined T2D and depression (OR: 1.84, 95% CI: 1.25–2.70). Though we found no association between the combined effect of the genetic IVs for T2D and depression with EggerMR(OR: 0.95, 95%CI: 0.42–2.14), we found an association for T2D and depression with IVW (OR: 1.75, 95% CI: 1.31–2.46) after excluding pleiotropic SNPs. Overall, the MR analyses provide evidence inferring a potential causal relationship between T2D and depression.

关键词： causal modeling depression Mendelian randomization type 2 diabetes

type 2 diabetes and bone fragility in children and adults

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World Journal of diabetes 2022年第11期13卷 900-911页

作者： Maria Felicia Faienza Paola Pontrelli Giacomina Brunetti Department of Biomedical Sciences and Human Oncology Pediatric UnitUniversity of Bari Aldo MoroBari 70124Italy Division of Nephrology Department of Emergency and Organ TransplantationUniversity of Bari Aldo MoroBari 70124Italy Department of Biosciences Biotechnologies and BiopharmaceuticsUniversity of Bari Aldo MoroBari 70125Italy

type 2 diabetes(T2D)is a global epidemic *** prevalence of T2D in adolescents and young adults is increasing *** mechanisms leading to T2D in young people are similar to those in older ***,the severity of onset,reduced insulin sensitivity and defective insulin secretion can be different in subjects who develop the disease at a younger age.T2D is associated with different complications,including bone fragility with consequent susceptibility to *** purpose of this systematic review was to describe T2D bone fragility together with all the possible involved *** studies have reported that patients with T2D show preserved,or even increased,bone mineral density compared with *** apparent paradox can be explained by the altered bone quality with increased cortical bone porosity and compromised mechanical ***,reduced bone turnover has been described in T2D with reduced markers of bone formation and *** findings prompted different researchers to highlight the mechanisms leading to bone fragility,and numerous critical altered pathways have been identified and *** detail,we focused our attention on the role of microvascular disease,advanced glycation end products,the senescence pathway,the Wnt/β-catenin pathway,the osteoprotegerin/receptor-activator of nuclear factor kappa B ligand,osteonectin and fibroblast growth factor *** understanding of type 2 myeloid bone fragility is an important issue as it could suggest possible interventions for the prevention of poor bone quality in T2D and/or how to target these pathways when bone disease is clearly evident.

关键词： type 2 diabetes Bone remodeling Cytokines Bone fragility Bone mineral density Chronic kidney disease

type 2 diabetes and quality of life

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World Journal of diabetes 2017年第4期8卷 120-129页

作者： Aikaterini Trikkalinou Athanasia K Papazafiropoulou Andreas Melidonis Department of Internal Medicine and diabetes Center Tzaneio General Hospital of Piraeus18536 PiraeusGreece

It is true that a primary goal of diabetes early diagnosis and treatment is quality of life(QoL). The term QoL is still confusing but it is agreed that it composes of four components:The physical component, mental, cogitative component, psychological and social component. Many articles have been written addressing those four components. During the last five years 15500 articles and reviews have been written addressing diabetes and coronary arterial disease, 16100 addressing diabetes and renal function, 28900 addressing diabetes and retinopathy, 16800 addressing diabetic foot ulcers and other 26300 addressing diabetic neuropathy. Moreover 17200 articles are dealing with diabetic sexual dysfunction, 24500 with the correlation of diabetes and depression 17500 about diabetes and dementia, only 1 about diabetes and family functioning and 1950000 about diabetes and QoL, indicating the worldwide interest. In order to confront this metabolic anomaly and its consequences, researchers developed numerous generic and disease specific psychometric tools. With the aid of those psychometric tools the scientific community has started to realize the gruesome effect of diabetes on patients' lives. Diabetic's QoL becomes worse when complications start to develop or comorbidities coexist. Dominant amongst complications, in health-related quality of life(HRQoL) lowering, but not related to risk factors(genetic, the weight of birth, or others) is coronary arterial disease followed by renal failure, blindness, and the combination of micro-and macrovascular complications and in some studies by sexual dysfunction. Moreover many are the comorbidities which deteriorate further the effect of diabetes in a patient life. Among them obesity, hypertension, dyslipidemia, depression, arthritis are the most common. Most intriguing field for research is the interaction of diabetes and depression and in some cases the progression to dementia. Many aspects and combinations of actions are under researche

关键词： type 2 diabetes Quality of life diabetes co morbidities diabetes complications Dementia diabetes type 3