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Performance and correlation of QuantiFERON-TB Gold, *** and tuberculin skin test in young children with or exposed to tuberculosis

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Asian Pacific Journal of Tropical Medicine 2020年第9期13卷 423-425页

作者： Keswadee Lapphra Paninun Srinuchasart Sansnee Senawong Utane Rungpanich Pinklow Umrod Alan Maleesatharn Nantaka Kongstan Watcharee Lermankul Kulkanya Chokephaibulkit Department of Pediatrics Faculty of Medicine Siriraj HospitalMahidol UniversityBangkokThailand Department of Immunology Faculty of Medicine Siriraj HospitalMahidol UniversityBangkokThailand

Objective:To evaluate the performance of interferon gamma release assays and tuberculin skin test in Bacillus Calmette-Guerin vaccinated young ***:A cross-sectional study was conducted in healthy children younger than 5 years who were recently diagnosed with tuberculosis or had recent exposure to active ***-TB Gold,*** and tuberculin skin test were performed in each ***:Of the 60 children,median age 3.3 years,17 had tuberculosis and 43 had recent tuberculosis ***,15(25.0%)children had tuberculin skin test reaction≥10 mm;8(13.3%)were positive by QuantiFERON-TB Gold In-Tube test,and 12(20.0%)by ***(31.7%)children had at least one positive *** was a moderate agreement between interferon gamma release assays and tuberculin skin ***:The positive rates of interferon gamma release assays and tuberculin skin test were low in young children who were infected with tuberculosis,supporting the management strategy of not testing children younger than 5 years.

关键词： tuberculin skin test QuantiFERON-TB Gold In-Tube test T-SPOT.TB Young children

Performance and correlation of interferon gamma release assays and tuberculin skin test in HIV-infected children and adolescents with immune reconstitution

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Asian Pacific Journal of Tropical Medicine 2020年第10期13卷 464-466页

作者： Keswadee Lapphra Rati Diwitaya Sansnee Senawong Maneeprang Thovarabha Parnwas Pinnobphun Alan Maleesatharn Nantaka Kongstan Benjawan Khumcha Wanatpreeya Phongsamart Orasri Wittawatmongkol Supattra Rungmaitree Kulkanya Chokephaibulkit Department of Pediatrics Faculty of Medicine Siriraj HospitalMahidol UniversityBangkokThailand Department of Immunology Faculty of Medicine Siriraj HospitalMahidol UniversityBangkokThailand Biomed Diagnostics(Thailand)Co LTD BangkokThailand

Objective:To evaluate the performance of interferon gamma release assays and tuberculin skin test in HIV-infected children and adolescents with immune ***:A cross-sectional study was conducted in HIV-infected patients aged 5-18 years receiving antiretroviral treatment with CD4 T-lymphocytes>25%or>500 cells/mm3 for at least 6 *** ERON-TB Gold,***,and tuberculin skin test were performed in each ***:A total of 50 patients were enrolled with median age of 13.7 years,CD4 counts of 753(IQR:587-989)cells/*** 27 patients with tuberculosis(16)or tuberculosis exposure(11),8(29.6%)were positive to at least one test,2(7.4%)were positive QuantiFERON-TB Gold,3(11.1%)positive ***,and 7(25.9%)had tuberculin skin test≥5 *** 23 patients without history of tuberculosis or exposure,all had negative interferon gamma release assays,while 2(8.7%)had positive tuberculin skin ***:All tests had low sensitivity despite immune reconstitution.

关键词： Children HIV TB Interferon gamma release assays tuberculin skin test

Comparison between Quanti-FERON-TB Gold In-Tube test and tuberculin skin test for diagnosis of latent tuberculosis in children: A cross-section study

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Journal of Acute Disease 2020年第2期9卷 73-77页

作者： Keyghobad Ghadiri Alisha Akya Maryam Janatolmakan Mansour Rezaei Seyed AmirabbasSharif Shahla Masoomshahi Raha Khosravi Roya chegenelorestani Infectious Diseases Research Center Kermanshah University of Medical SciencesKermanshahIran Clinical Research Development Center Imam Reza HospitalKermanshah University of Medical SciencesKermanshahIran Social Development and Health Promotion Research Center Kermanshah University of Medical SciencesKermanshahIran Infectious Diseases Research Centre Kashan University of Medical SciencesKashanIran Pediatric Pathology Research Center Research Institute for Children HealthMofid Children HospitalShahid Behehsti University of Medical SciencesTehranIran

Objective: To compare Quanti-FERON-TB Gold In-Tube (QFT-GIT) test and tuberculin skin test (TST) for the diagnosis of latent tuberculosis infection in children. Methods: In this cross-sectional study, 64 participants who were between 3 months and 14 years old and had close contact with smear-positive pulmonary tuberculosis were included. Both QFT-GIT test and TST were done and the results were analyzed by SPSS software and Kappa test. Results: The distribution of gender and age according to QFT-GIT and TST results were matched (P>0.05). Overall agreement between QFT-GIT and TST for diagnosis of latent tuberculosis infection in children was 75%. In addition, the contingency coefficient was 0.257, and the Kappa measure of agreement was 0.246 (P=0.034). Conclusions: Compared to TST, QFT-GIT shows no apparent advantage for diagnosis of latent tuberculosis infection in children.

关键词： Tuberculosis Latent tuberculosis infection tuberculin skin test Quanti FERON

Indications, Interpretation and Clinical Consequences of tuberculin skin tests in Resource Limited Settings

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Journal of Tuberculosis Research 2021年第3期9卷 172-183页

作者： Fitzgerald A. Gopie Aabidien Hassankhan Wilco C. W. R. Zijlmans Stephen G. S. Vreden Faculty of Medical Sciences Anton de Kom University of Suriname Paramaribo Suriname Academic Hospital Paramaribo Paramaribo Suriname MoleMann Mental Health Suriname Paramaribo Suriname Department of Paediatrics Diakonessenhuis Hospital Paramaribo Suriname Department of Internal Medicine Academic Hospital Paramaribo Paramaribo Suriname

Objective: to evaluate the policy of TST testing in Suriname. As there is no gold standard to diagnose latent tuberculosis infection (LTBI), the tuberculin skin test (TST) is used to diagnose LTBI. However, internationally, the cut-off values of the TST are not uniform and depend on local tuberculosis (TB) epidemiology and guidelines for test initiation. In Suriname, where currently several indications exist for TSTs, cut-off values are set at 5 mm or 10 mm, depending on the age and/or medical history of the patient. LTBI classification is performed by pulmonologists primarily based on the American Thoracic Society targeted TB testing guidelines. Method: retrospective analysis of outpatient TST data between 2011 and 2019 from Suriname’s sole pulmonary medicine clinic. Result: 1373 patients were evaluated. 590 patients were from the screening group of whom 253 had a positive TST result, 46 of whom were classified as LTBI. In the contact tracing group of 649 patients, 616 had a positive TST, 352 of whom were classified as LTBI. In the medical condition group of 134 patients, 96 had a positive TST, 38 of whom were classified as LTBI. Eventually, positive TST results were found for 965 tested patients: 436 patients were classified as LTBI and 529 non-LTBI patients were not prescribed chemoprophylaxis. None of the non-LTBI TST-positive patients were diagnosed with active TB, including 174 patients with a TST result of 15 mm or greater and in need of IPT, but not prescribed by jud

A prospective longitudinal study for latent tuberculosis infection in hospital in Beijing evaluating a T-cell-based assay health-care workers in a general

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Chinese Medical Journal 2013年第11期126卷 2039-2044页

作者： ZHANG Li-fan LIU Xiao-qing ZHANG Yao DENG Guo-hua Manish Pareek Ajit Lalvani Department of Infectious Diseases Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100730 China Clinical Epidemiology Unit Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100730 China

Background The health-care workers （HCWs） are at high risk of acquiring infection with Mycobacterium tuberculosis. The objectives of this study were to compare the performance of the *** and tuberculin skin test （TST） for latent tuberculosis infection （LTBI）, evaluate diagnostic concordance and risk factors for LTBI, and observe the progression to active tuberculosis （TB） disease among HCWs in a general hospital in Beijing. Methods The prospective cohort study enrolled HCWs in a tertiary general hospital in Beijing, China, to evaluate LTBI with *** and TST. The subjects were evaluated every 12 months during the 60-month follow-up. Results Of 101 participating HCWs, 96 and 101 had valid TST and *** results, respectively. Twenty-nine （28.7%, 95% confidence interval （C/）, 19.9%-37.5%） were defined as positive by *** and 53 （55.2%, 95% CI, 45.2%-64.9%） were defined as positive by TST （using a ≥10 mm cutoff）. An agreement between the two tests was poor （57.3%, K=0.18, 95% CI, 0.01%-0.52%）. In multJvariate analysis, direct exposure to sputum smear-positive TB patients was a significant risk factor for a positive *** （OR 5.76; 95% CI 1.38-24.00）. Pooled frequency of antigen- specific IFN-y secreting T-cells for subjects who reported direct contact with sputum smear-positive TB patients was significantly higher than that for participants without direct contact （P=0.045）. One of 20 participants with positive result of *** and TST developed active TB at 24-month *** *** is a more accurate, targeted method of diagnosing LTBI than TST.

关键词： T-SPOT.TB latent tuberculosis infection tuberculin skin test exposure follow-up study

testing of tuberculosis infection among Chinese adolescents born after terminating the Bacillus Calmette-Guerin booster vaccination： subgroup analysis of a population-based cross-sectional study

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Frontiers of Medicine 2017年第4期11卷 528-535页

作者： Hengjing Li Henan Xin Shukun Qian Xiangwei Li Haoran Zhang Mufei Li Boxuan Feng Qi Jin Lei Gao MOH Key Laboratory of Systems Biology of Pathogens Institute of Pathogen Biology and Center for Tuberculosis Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China Beijing Rehabilitation Hospital of Capital Medical University Beijing 100043 China

The prevalence of tuberculosis infection among adolescents born after terminating the Bacillus Calmette-Guerin （BCG） booster vaccination in China was estimated using tuberculin skin testing （TST） and QuantiFERON-TB Gold assay （QFT） to investigate the influence of neonatal BCG vaccination on the performance of TST. Data analysis was conducted for 2831 eligible participants aged 5-15 years from the baseline survey of a population-based multi-center prospective study. The prevalence rates of TST （induration ≥ 10 mm） and QFT positivity were 9.3% （264/2827） and 2.5% （71/2831）, respectively. The rate of QFT indeterminate result was 2.2% （62/2831）. The overall agreement between TST and QFT was low （concordance = 88.0%; K coefficient = 0.125）. Only TST was positively associated with BCG vaccination with an adjusted odds ratio of 1.71 [95% confidence interval, 1.26-2.31 ]. A history of close contact with patients of active TB was significantly associated with positivity for TST and QFT. Our results suggested that BCG neonatal vaccination still affects TST performance, and a two- step approach might be considered for TB infection testing among adolescents in China.

关键词： tuberculin skin test interferon-γ release assays adolescent agreement

Latent tuberculosis infection in health-care workers in the government sector in Brunei Darussalam:A cross-sectional study

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中西医结合护理杂志(英文) 2023年第3期5卷 197-202页

作者： Nurin Jazmina Muhammad SYAFIQ Ashishkumar Akshaykumar TRIVEDI Alice LAI Maria Pureza Aurelio FONTELERA Mei Ann LIM PAPRSB Institute of Health Sciences Universiti Brunei DarussalamBandar Seri BegawanBrunei Darussalam Occupational Health Division Ministry of HealthBandar Seri BegawanBrunei Darussalam

Objective:Health-care workers(HCWs)are known to be at high risk for occupational biological hazards,and this includes exposure to mycobacterium tuberculosis(TB)which can result in either active or latent TB infection(LTBI).This study aims to provide an overview of the incidence of LTBI among HCWs in Brunei Darussalam,to examine associated risk factors,and to evaluate LTBI treatment *** and Methods:This is a retrospective cross-sectional study which was conducted using data from January 2018 to December 2021,on notified cases of LTBI in HCWs which identified 115 *** data,underlying medical conditions,and compliance to treatment were assessed through reviews of their electronic health ***:The incidence of LBTI was 14.6/year/1000 *** incidence rate reached a high of 24.6/1000 in 2020,and majority of cases were in the older age *** was good treatment acceptance and compliance(82.6%),and this was observed to be significantly higher in females than males(P=0.02).Conclusion:This study showed an average incidence of LTBI of 14.6/1000 HCWs over 4 years and high LTBI treatment acceptance(82.6%)and *** on infection prevention and control measures in health-care settings and actions to increase awareness of LTBI are crucial interventions toward reducing the burden of LTBI.

关键词： Health-care worker latent tuberculosis infection treatment latent tuberculosis infection tuberculin skin test

Prevalence of Bovine Tuberculosis in Sheep at Sadar and Parbatipur Upazila under Dinajpur District in Bangladesh

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Open Journal of Veterinary Medicine 2021年第11期11卷 315-326页

作者： Ahmed Ali Omar S. M. Harun-ur-Rashid Md. Haydar Ali Binti Abubakar Mohamed Head of Lab at Someat Company Mogadishu Somalia Faculty of Veterinary Science in Benadir University Mogadishu Somalia Faculty of Veterinary and Animal Science Department of Pathology and Parasitology in Hajee Mohammad Danesh Science and Technology University Dinajpur Bangladesh Faculty of Veterinary Medicine and Animal Husbandry at Horsed International University Mogadishu Somalia

Tuberculosis is Zoonotic disease and infected animals continue to spread the disease to other animals and humans by excreting the germs in milk, meat, feces, and respiratory droplets, this study used bPPD (Bovine purified protein derivative) to observe TST (tuberculin skin test) reactivity in the Sheep population in the Sadar and Parbatipur Upazilas of Dinajpur District. The research conducted from January to June of 2018. There is no history for sheep tuberculosis in the study area. Overall, 5 percent (7/140) of 140 sheep were positive, 15% (21/140) were doubtful, and 80% (112/140) were negative based on sex, age, breed, and body condition score, while lactation stage and reproduction status prevalence was 6.4 percent, 14.9 percent, and 78.7% positive, doubtful, and negative, respectively. Our findings suggest the presence of a skin test reaction response when employing the bPPD reagent, but this needs to be validated by pathological and serological techniques. Nevertheless, my preliminary investigation suggests that abattoirs must implement effective control systems and raise public awareness.

关键词： Sheep Tuberculosis tuberculin skin test bPPD Reagent

Does “Latent Tuberculosis Infection” (LTBI)” Really Exist? Genealogy of a Medical Nosology

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Journal of Tuberculosis Research 2021年第3期9卷 197-204页

作者： Patricia Etienne University Hospital of Guadeloupe Pointe-à-Pitre France

Introduction: The diagnosis of latent tuberculosis infection (LTBI) is based on secular ways: chest radiography and tuberculin skin test (TST). In front of a recent enthusiasm for LTBI, this paper reports a historical perspective of this concept. Method: Bibliometric analysis and literature review from medical databases, using the terms “latent tuberculosis infection (“LTBI”), “primary tuberculosis”, “tuberculin skin test”, “tuberculosis”, and from reference books on tuberculosis. Results: In the PubMED/MEDLINE search for LTBI, a total of 7787 articles were found between 1901 and 2020, 95% from 2000 to 2020. In the first part of the 20th century, LTBI term was used for sub-clinical tuberculosis disease, the latency being also called “primary tuberculosis” or “abortive tuberculosis infection”. From 1960, randomized prospective therapeutic studies mentioned “tuberculosis chemoprophylaxis”

关键词： tuberculin skin test Latent Tuberculosis Infection IGRA tests Medical History