Performance and correlation of QuantiFERON-TB Gold, *** and tuberculin skin test in young children with or exposed to tuberculosis

作     者：Keswadee Lapphra Paninun Srinuchasart Sansnee Senawong Utane Rungpanich Pinklow Umrod Alan Maleesatharn Nantaka Kongstan Watcharee Lermankul Kulkanya Chokephaibulkit Keswadee Lapphra;Paninun Srinuchasart;Sansnee Senawong;Utane Rungpanich;Pinklow Umrod;Alan Maleesatharn;Nantaka Kongstan;Watcharee Lermankul;Kulkanya Chokephaibulkit

作者机构：Department of PediatricsFaculty of Medicine Siriraj HospitalMahidol UniversityBangkokThailand Department of ImmunologyFaculty of Medicine Siriraj HospitalMahidol UniversityBangkokThailand 

出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)

年 卷 期：2020年第13卷第9期

页      面：423-425页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by the Faculty of Medicine Siriraj Hospital,Mahidol University,Bangkok,Thailand,[Grant Number(IO)R016032002] Oxford Immunotec and Biomed diagnostics(Thailand)provided the T-SPOT.TB test kit 

主　　题：Tuberculin skin test QuantiFERON-TB Gold In-Tube test T-SPOT.TB Young children 

摘      要：Objective:To evaluate the performance of interferon gamma release assays and tuberculin skin test in Bacillus Calmette-Guerin vaccinated young ***:A cross-sectional study was conducted in healthy children younger than 5 years who were recently diagnosed with tuberculosis or had recent exposure to active ***-TB Gold,*** and tuberculin skin test were performed in each ***:Of the 60 children,median age 3.3 years,17 had tuberculosis and 43 had recent tuberculosis ***,15(25.0%)children had tuberculin skin test reaction≥10 mm;8(13.3%)were positive by QuantiFERON-TB Gold In-Tube test,and 12(20.0%)by ***(31.7%)children had at least one positive *** was a moderate agreement between interferon gamma release assays and tuberculin skin ***:The positive rates of interferon gamma release assays and tuberculin skin test were low in young children who were infected with tuberculosis,supporting the management strategy of not testing children younger than 5 years.