检索结果-南通市图书馆

Negative association of Time in range and urinary albumin excretion rate in patients with type 2 diabetes mellitus:a retrospective study of inpatients

引用

Chinese Medical Journal 2022年第9期135卷 1052-1056页

作者： Sanbao Chai Shanshan Wu Sixu Xin Ning Yuan Jianbin Sun Xiaomei Zhang Linong Ji Department of Endocrinology and Metabolism Peking University International HospitalBeijing 102206China National Clinical Research Center of Digestive Diseases Capital Medical University Affiliated Beijing Friendship HospitalBeijing 100050China Department of Endocrinology and Metabolism Peking University People's HospitalBeijing 100044China

Background:Time in range(TIR)refers to the time an individual spends within their target glucose range,which now has been popularized as an important metric to classify glycemic management and also recognized as an important outcome of current diabetes therapies.This study aimed to investigate the association between TIR and the severity of the urinary albumin excretion rate(UAER)in patients with type 2 diabetes mellitus(T2DM).Methods:We retrospectively analyzed the data of 1014 inpatients with T2DM at the Department of Endocrinology and Metabolism of Peking University International Hospital,China.TIR was defined as the percentage of blood glucose within the target range of 3.90-10.00 mmol/L.Urine samples for assessment of UAER were collected for 3 consecutive days from the start of hospitalization.Results:The TIR values for patients with normal urine levels of albumin,microalbuminuria,and macroalbuminuria were 70%±20%,50%±20%,and 30%±20%,respectively(allP83%.The incidences of microalbuminuria in Q1,Q2,Q3,and Q4 were 41.1%,21.6%,7.1%,and 5.5%(allP<0.001),respectively.The respective incidences of macroalbuminuria were 24.2%,1.1%,1.4%,and 0%(allP<0.001).In multinomial logistic regression analyses,TIR was significantly correlated with microalbuminuria(odds ratio[OR]0.58,95%confidence interval[CI]:0.52-0.65,P<0.001)and macroalbuminuria(OR 0.26,95%CI:0.18-0.38,P<0.001)after adjusting for age,sex,body mass index,diabetes duration,systolic blood pressure,and levels of triglycerides,glycosylated hemoglobin A1c,and creatinine.Conclusion:The proportion of blood glucose in TIR is closely related to the severity of UAER in patients with T2DM.

关键词： Time in range Type 2 diabetes Urinary albumin excretion rate Blood glucose

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Association between Time in range and cancer mortality among patients with type 2 diabetes:a prospective cohort study

引用

Chinese Medical Journal 2022年第3期135卷 288-294页

作者： Yun Shen Chunfang Wang Yaxin Wang Jingyi Lu Lei Chen Lei Zhang Wei Lu Wei Zhu Gang Hu Tian Xia Jian Zhou Department of Endocrinology and Metabolism Shanghai Jiao Tong University Affiliated Sixth People's HospitalShanghai Clinical Center for DiabetesShanghai Key Clinical Center for Metabolic DiseaseShanghai Key Laboratory of Diabetes MellitusShanghai 200233China Pennington Biomedical Research Center Baton RougeLA 70808USA Division of Vital Statistics Institute of Health InformationShanghai Municipal Center for Disease Control and PreventionShanghai 200336China Shanghai Diabetes Institute Shanghai Jiao Tong University Affiliated Sixth People's HospitalShanghai 200233China

Background:Little was known about the association among Time in range(TIR),time above range(TAR),time below range(TBR),and cancer mortality among patients with type 2 diabetes.We aimed to investigate the association among TIR,TAR,TBR,and the risk of cancer mortality among patients with type 2 diabetes.Methods:A total of 6225 patients with type 2 diabetes were prospectively recruited in Shanghai,China.TIR was measured with continuous glucose monitoring at baseline and was defined as the average percentage of time in the target glucose range during a 24 h period.Cox proportion hazard regression analysis was used to determine the association between TIR and the risk of cancer mortality.Results:During a mean follow-up of 7.10 years,we confirmed 237 death events related to cancer.The multivariable-adjusted hazard ratio(HR)for cancer mortality was 1.32(95%confidence interval[CI]:1.01-1.75)in patients with TIR≤70%compared with those with TIR>70%.When TIR was considered as a continuous variable,the multivariable-adjusted HR for cancer mortality associated with each 10%decrease in TIR was 1.07(95%CI:1.02-1.14).In the site-specific analysis,a significant association between TIR as a continuous variable and the risk of hepatocellular cancer was found(HR:1.24;95%CI:1.09-1.41).However,no relationship between hemoglobin A1c and cancer mortality was observed(HR:1.04;95%CI:0.97-1.10).Conclusions:The present study found an inverse association of TIR with the risk of cancer mortality among patients with type 2 diabetes.New evidence of TIR was added into the clinical practice that TIR may be an optimal target of glycemic control among patients with type 2 diabetes.

关键词： Time in range HbA1c Type 2 diabetes Cancer mortality Cohort study Hepatocellular cancer

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Research progress in the application of Time in range: more than a percentage

引用

Chinese Medical Journal 2023年第5期136卷 522-527页

作者： Jintao Wan Jingyi Lu Cheng Li Xiaojing Ma Jian Zhou Department of Endocrinology and Metabolism Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai Clinical Center for DiabetesShanghai Key Clinical Center for Metabolic DiseaseShanghai Diabetes InstituteShanghai Key Laboratory of Diabetes MellitusShanghai 200233China.

Glucose monitoring is an important part of medical care in diabetes mellitus,which not only helps assess glycemic control and treatment safety,but also assists with treatment adjustment.With the development of continuous glucose monitoring(CGM),the use of CGM has increased rapidly.With the wealth of glucose data produced by CGM,new metrics are greatly needed to optimally evaluate glucose status and guide the treatment.One of the parameters that CGM provides,Time in range(TIR),has been recognized as a key metric by the international consensus.Before the adoption of TIR in clinical practice,several issues including the minimum length of CGM use,the setting of the target range,and individualized TIR goals are summarized.Additionally,we discussed the mounting evidence supporting the association between TIR and diabetes-related outcomes.As a novel glucose metric,it is of interest to compare TIR with other conventional glucose markers such as glycated hemoglobin A1c.It is anticipated that the use of TIR may provide further information on the quality of glucose control and lead to improved diabetes management.

关键词： Diabetes mellitus Time in range Continuous glucose monitoring

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Relationship between Time in range and corneal nerve fiber loss in asymptomatic patients with type 2 diabetes

引用

Chinese Medical Journal 2022年第16期135卷 1978-1985页

作者： Wejing Zhao Jingyi Lu Lei Zhang Wei Lu Wei Zhu Yuqian Bao Jjian Zhou 'Department of Endocrinology and Metabolism Shanghai Jiao Tong Universty Ailatede Sith People's HospitalShanghai Cinical Center for DiabetesShanghai Key Clinical Center for Metabolic DiseaseShanghai Diabetes IstuteShanghai Key Laboratory of Diabetes MellitusShanghai 200233China Shanghai Clinical Center for Metabolic Diseases Shanghai Key Laboratory of Diabetes MeliusShanghai Diabetes IstituteShanghai Jiao Tong University Alilatedae Sith People's HospitalShanghai 200233China Department of Endocrinology and Metabolism Jinshan Branch of Shanghai Jiao Tong University Aflatedae Sixth People's HospitalShanghai 201500China

Background: Corneal confocal microscopy (CCM) is a noninvasive technique to detect early nerve damage of diabetic sensorimotor polyneuropathy (DSPN). Time in range (TIR) is an emerging metric of glycemic control which was reported to be associated with diabetic complications. We sought to explore the relationship between TIR and corneal nerve parameters in asymptomatic patients with type 2 diabetes (T2DM).Methods: In this cross-sectional study, 206 asymptomatic inpatients with T2DM were recruited. After 7 days of continuous glucose monitoring, the TIR was calculated as the percentage of time in the glucose range of 3.9 to 10.0 mmol/L. CCM was performed to determine corneal nerve fiber density, corneal nerve branch density, and corneal nerve fiber length (CNFL). Abnormal CNFL was defined as ≤15.30 mm/mm2.Results: Abnormal CNFL was found in 30.6% (63/206) of asymptomatic subjects. Linear regression analyses revealed that TIR was positively correlated with CCM parameters both in the crude and adjusted models (all P< 0.05). Each 10% increase in TIR was associated with a 28.2% (95% CI: 0.595–0.866,P = 0.001) decreased risk of abnormal CNFL after adjusting for covariates. With the increase of TIR quartiles, corneal nerve fiber parameters increased significantly (allP for trend <0.01). The receiver operating characteristic curve indicated that the optimal cutoff point of TIR was 77.5% for predicting abnormal CNFL in asymptomatic patients.Conclusions: There is a significant independent correlation between TIR and corneal nerve fiber loss in asymptomatic T2DM patients. TIR may be a useful surrogate marker for early diagnosis of DSPN.

关键词： Continuous glucose monitoring Corneal confocal microscopy Time in range Type 2 diabetes

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Time in range as a useful marker for evaluating retinal functional changes in diabetic retinopathy patients

引用

International Journal of Ophthalmology(English edition) 2023年第6期16卷 915-920页

作者： Dan-Dan Zhu Xuan Wu Xin-Xuan Cheng Ning Ding Department of Ophthalmology Nanjing Drum Tower Hospitalthe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210000Jiangsu ProvinceChina Department of Ophthalmology Nanjing Drum Tower Hospital Group Suqian HospitalSuqian 223800Jiangsu ProvinceChina Department of Nutrition and Food Hygiene Nanjing University of Chinese MedicineNanjing 210000Jiangsu ProvinceChina

·AIM:To elucidate the relationship between macular sensitivity and Time in range(TIR)obtained from continuous glucose monitoring(CGM)measures in diabetic patients with or without diabetic retinopathy(DR).·METHODS:This was a cross-sectional study including 100 eyes of non-DR patients and 60 eyes of DR patients.An advanced microperimetry was used to quantitate the retinal mean sensitivity(MS)and fixation stability in central macula.TIR of 3.9-10.0 mmol/L was evaluated with CGM.Pearson coefficient analysis and multiple linear regression analysis were used to assess the correlation between TIR and retinal sensitivity.·RESULTS:In a comparison of non-DR patients,significant differences(P0.05).A multivariable linear regression analysis was performed to prove that TIR and SDBG were both independent risk factors for MS reduction in the DR group.·CONCLUSION:TIR is correlated with retinal MS reduction in DR patients,suggesting a useful option for evaluating DR progression.

关键词： diabetic retinopathy Time in range microperimetry continuous glucose monitoring

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Continuous glucose monitoring defined time-in-range is associated with sudomotor dysfunction in type 2 diabetes

引用

World Journal of Diabetes 2020年第11期11卷 489-500页

作者： Qing-Yu Guo Bin Lu Zhan-Hong Guo Zhou-Qin Feng Yan-Yu Yuan Xu-Guang Jin Pu Zang Ping Gu Jia-Qing Shao Department of Endocrinology Jinling HospitalSchool of MedicineNanjing UniversityNanjing 210002Jiangsu ProvinceChina Department of Endocrinology Jinling HospitalNanjing Medical UniversityNanjing 210002Jiangsu ProvinceChina Department of Endocrinology Jinling HospitalSouthern Medical UniversityNanjing 210002Jiangsu ProvinceChina

BACKGROUND Time in range(TIR),as a novel metric for glycemic control,has robust relevance with diabetic complications.Diabetic peripheral neuropathy(DPN)is characterized by sudomotor dysfunction.AIM To explore the relationship between TIR obtained from continuous glucose monitoring(CGM)and sudomotor function detected by SUDOSCAN in subjects with type 2 diabetes.METHODS The research enrolled 466 inpatients with type 2 diabetes.All subjects underwent 3-d CGM and SUDOSCAN.SUDOSCAN was assessed with electrochemical skin conductance in hands(HESC)and feet(FESC).Average feet ESCtime when blood glucose is between 3.9-10 mmol/L during 1 d period.RESULTS Among the enrolled subjects,135(28.97%)presented with sudomotor dysfunction.Patients with sudomotor dysfunction(+)showed a decreased level of TIR(P<0.001).Compared to the lowest tertile of TIR,the middle and the highest tertiles of TIR was associated with an obviously lower prevalence of sudomotor dysfunction(20.51%and 21.94%vs 44.52%)(P<0.001).In addition,with the increase of TIR,HESC and FESC increased(P<0.001).Regression analysis demonstrated that TIR was inversely and independently linked with the prevalence of sudomotor dysfunction after adjusting for confounding values(odds ratio=0.979,95%CI:0.971-0.987,P<0.001).CONCLUSION The tight glycemic control assessed by TIR is of vitally protective value for sudomotor dysfunction in type 2 diabetes mellitus.

关键词： Time in range Sudomotor dysfunction SUDOSCAN Diabetic peripheral neuropathy Continuous glucose monitoring Diabetes mellitus Type 2

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Use of Standardized Reporting and time-in-range in the Management of Diabetes: A Consensus Report

引用

International Journal of Clinical Medicine 2021年第8期12卷 316-327页

作者： Saud Al Sifri Adnan Alshaikh Bassam Bin-Abbas Eman Sheshah Fahad Al Sabaan Mohammed Al-Dawish Mohammed Al-Dubayee Naweed Al-Zaman Raed A. Al-Dahash Saad Alzahrani Emad R. Issak Endocrinology and Diabetes Department Alhada and Taif Armed Forces Hospitals Taif Saudi Arabia Pediatrics Department King Abdulaziz Medical City—Ministry of National Guard Health Affairs King Khalid National Guard Hospital Jeddah Saudi Arabia Pediatrics Department King Faisal Specialist Hospital and Research Center Riyadh Saudi Arabia Endocrinology Department King Salman hospital Riyadh Saudi Arabia Endocrinology Department Security forces hospital program Riyadh Saudi Arabia Endocrinology Department Prince Sultan Military Medical City (PSMMC) Riyadh Saudi Arabia Pediatrics Department Ministry of National Guard Health Affairs-Riyadh Riyadh Saudi Arabia Endocrinology Department Taibah University Madina Saudi Arabia Internal Medicine Department King Abdulaziz Medical City—National Guard Riyadh Saudi Arabia Endocrinology Department Medical Director OEMC King Fahad Medical City Riyadh Saudi Arabia Internal Medicine Department Faculty of Medicine Ain-Shams University Cairo Egypt

Introduction: The exhaustion of healthcare resources due to the rising prevalence in Saudi Arabia mandates the search for each method that can help in better control of diabetes. Methods: The gathered task force gath-ered to develop an explicit, evidence-based consensus for the use of time-in-range targets as guidance for better glycemic control while using continuous glucose monitoring (CGM). This article has the recommenda-tions of this expert panel. Results: HbA1c and self-monitoring blood glu-cose (SMBG) are not enough to detect blood glucose (BG) fluctuations on a daily basis. The incorporation of technology like FreeStyle Libre with its applications like Libre View is now used in many institutes in Saudi Ara-bia. This system is comprehensive and has all the standardized metrics needed. However, training and support are always needed. Barriers and challenges include the awareness & experience of the technology, the time barrier, the patients’ barriers, the technical barriers, and of course, the availability barrier. All the barriers and challenges should be dealt with by designing new training programs. Conclusion: The expert panel recom-mended using CGMs technology in people with type 1 diabetes (T1DM) children and adults, type 2 diabetes (T2DM) on multiple insulin injections, gestational diabetes (GDM) who need further glycemic control, and those at high risk for hypoglycemia. In addition, we recommend using them for a short period for those who require intensive BG control or during acute illness or stress. In addition, Ambulatory Glucose Profile (AGP) could be used as an educational tool for any individuals with DM to study the im-pact of certain elements of lifestyle modifications on their immediate BG level.

关键词： Diabetes Time in range Glycemic Control HbA1c

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：