Negative association of time in range and urinary albumin excretion rate in patients with type 2 diabetes mellitus:a retrospective study of inpatients

作     者：Sanbao Chai Shanshan Wu Sixu Xin Ning Yuan Jianbin Sun Xiaomei Zhang Linong Ji Sanbao Chai;Shanshan Wu;Sixu Xin;Ning Yuan;Jianbin Sun;Xiaomei Zhang;Linong Ji

作者机构：Department of Endocrinology and MetabolismPeking University International HospitalBeijing 102206China National Clinical Research Center of Digestive DiseasesCapital Medical University Affiliated Beijing Friendship HospitalBeijing 100050China Department of Endocrinology and MetabolismPeking University People's HospitalBeijing 100044China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2022年第135卷第9期

页      面：1052-1056页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Time in range Type 2 diabetes Urinary albumin excretion rate Blood glucose 

摘      要：Background:Time in range(TIR)refers to the time an individual spends within their target glucose range,which now has been popularized as an important metric to classify glycemic management and also recognized as an important outcome of current diabetes *** study aimed to investigate the association between TIR and the severity of the urinary albumin excretion rate(UAER)in patients with type 2 diabetes mellitus(T2DM).Methods:We retrospectively analyzed the data of 1014 inpatients with T2DM at the Department of Endocrinology and Metabolism of Peking University International Hospital,*** was defined as the percentage of blood glucose within the target range of 3.90-10.00 mmol/*** samples for assessment of UAER were collected for 3 consecutive days from the start of ***:The TIR values for patients with normal urine levels of albumin,microalbuminuria,and macroalbuminuria were 70%±20%,50%±20%,and 30%±20%,respectively(allP83%.The incidences of microalbuminuria in Q1,Q2,Q3,and Q4 were 41.1%,21.6%,7.1%,and 5.5%(allP0.001),*** respective incidences of macroalbuminuria were 24.2%,1.1%,1.4%,and 0%(allP0.001).In multinomial logistic regression analyses,TIR was significantly correlated with microalbuminuria(odds ratio[OR]0.58,95%confidence interval[CI]:0.52-0.65,P0.001)and macroalbuminuria(OR 0.26,95%CI:0.18-0.38,P0.001)after adjusting for age,sex,body mass index,diabetes duration,systolic blood pressure,and levels of triglycerides,glycosylated hemoglobin A1c,and ***:The proportion of blood glucose in TIR is closely related to the severity of UAER in patients with T2DM.