Association of point in range withβ-cell function and insulin sensitivity of type 2 diabetes mellitus in cold areas

作     者：Yanan Ni Dan Liu Xiaona Zhang Hong Qiao Yanan Ni;Dan Liu;Xiaona Zhang;Hong Qiao

作者机构：Department of EndocrinologyNO.2 Affiliated Hospital of Harbin Medical UniversityHarbin 150081China Department of BiostatisticsHarbin Medical UniversityHarbin 150086China 

出 版 物：《Frigid Zone Medicine》 (寒地医学（英文）)

年 卷 期：2023年第3卷第4期

页      面：242-252,I0014页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：time in range points in range self-monitoring of blood glucose β-cell function insulin sensitivity 

摘      要：Background and Objective:Self-monitoring of blood glucose(SMBG)is crucial for achieving a glycemic target and upholding blood glucose stability,both of which are the primary purpose of anti-diabetic ***,the association between time in range(TIR),as assessed by SMBG,andβ-cell insulin secretion as well as insulin sensitivity remains ***,this study aims to investigate the connections between TIR,derived from SMBG,and indices representingβ-cell functionality and insulin *** primary objective of this study was to elucidate the relationship between short-term glycemic control(measured as points in range[PIR])and bothβ-cell function and insulin ***:This cross-sectional study enrolled 472 hospitalized patients with type 2 diabetes mellitus(T2DM).To assessβ-cell secretion capacity,we employed the insulin secretion-sensitivity index-2(ISSI-2)and(ΔC-peptide_(0-120)/Δglucose_(0-120))×Matsuda index,while insulin sensitivity was evaluated using the Matsuda index and *** SMBG offers glucose data at specific point-in-time,we substituted TIR with *** to clinical guidelines,values falling within the range of 3.9-10 mmol were consideredin range,and the corresponding percentage was calculated as ***:We observed significant associations between higher PIR quartiles and increased ISSI-2,(ΔC-peptide_(0-120)/Δglucose_(0-120))×Matsuda index,Matsuda index(increased)and HOMA-IR(decreased)(all P0.001).PIR exhibited positive correlations with log ISSI-2(r=0.361,P0.001),log(ΔC-peptide_(0-120)/Δglucose_(0-120))×Matsuda index(r=0.482,P0.001),and log Matsuda index(r=0.178,P0.001)and negative correlations with log HOMA-IR(r=-0.288,P0.001).Furthermore,PIR emerged as an independent risk factor for log ISSI-2,log(ΔC-peptide_(0-120)/Δglucose_(0-120))×Matsuda index,log Matsuda index,and log ***:PIR can serve as a valuable tool for assessingβ-cell function and insulin sensitivity.