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The Number of Lymph Nodes and Relationship with Presence of thyroiditis and Thymic Tissue in the Central Neck Dissection Materials for thyroid papillary carcinoma: Pathologic Analysis

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International Journal of Clinical Medicine 2016年第9期7卷 566-576页

作者： Banu Bilezikçi Seyfettin Ilgan Serdar Özbaş Savaş Koçak Departments of Pathology Guven Hospital Ankara Turkey Departments of Nuclear Medicine Guven Hospital Ankara Turkey Departments of Endocrine Surgery Guven Hospital Ankara Turkey

Background: Central lymph node dissection (CLND) for papillary thyroid carcinoma (PTC) allows correct pathologic staging of lymph nodes and planning of postoperative management. The purpose of this study was to determine the number of the lymph nodes in the CLND and the relationship to presence of chronic lymphocytic thyroiditis (CLT) and thymic tissue (TT). Methods: Total thyroidectomy and CLND materials from 153 patients with PTC were included in this study. Two histopathologic features (presence of CLT and TT) were evaluated for their value in adequacy of CLND. Results: Histopathologic examination revealed CLT and TT in CLND materials in 70 (46%) and 63 (41%) patients, respectively. Total number of lymph nodes in CLND materials was significantly higher in CLT (+) and TT (+) groups (p Conclusions: Our study demonstrates that presence of CLT in thyroid gland has been associated with higher number of central lymph nodes mainly due to increased number of benign hyperplastic lymph nodes. It may be possible to conclude that upper limit of lymph nodes for satisfactory CLND would be higher to correctly evaluate central lymph node status in existing staging systems if specimens have CLT. Results of this study also show that the presence of TT in surgical materials may represent the adequacy of CLND.

关键词： thyroid papillary carcinoma Central Lymph Node Dissection thyroiditis Thymus

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Diagnostic Value of Serum TSH,Ultrasound,and Enhanced CT in papillary thyroid carcinoma with Lymph Node Metastasis

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Proceedings of Anticancer Research 2022年第4期6卷 59-64页

作者： Meiqing He Xixi Zhang Hui Li Tian Wang Ultrasonic Diagnosis Center of Shaanxi Provincial People’s Hospital Xi’an 710068Shaanxi ProvinceChina

Objective:To explore the diagnostic value of serum TSH,ultrasound,and enhanced CT in papillary thyroid carcinoma with lymph node ***:168 patients who underwent thyroidectomy in Shaanxi Provincial People’s Hospital from January 2020 to December 2021 were selected as the research *** on the pathological nature(benign or malignant),they were divided into two groups,with 86 patients in the control group and 82 patients in the study *** on whether the pathology was accompanied with lymph node metastasis,the PTC group was divided into a lymph node metastasis group and a non-lymph node metastasis group,with 51 and 31 patients in the respective *** analysis was conducted to observe and analyze the pathological results of the thyroid nodules’thyroid ultrasound results,neck enhanced CT results,and thyroid function test serology ***:Compared with the PTC group,there were significant differences in TR classification,ultrasonic lymph nodes,and enhanced CT lymph nodes,but no significant differences in the course of disease,nodule distribution,and the number of nodules between the benign nodule group and PTC group;in the comparison of lymph node metastasis using ultrasound and enhanced CT,the number of patients with ultrasound lymph nodes without abnormal metastasis in the non-metastasis group was 28,while that of the metastasis group was 21;the number of patients with abnormal metastasis in the non-metastasis group was 3,while that of the metastasis group was *** number of patients with a single node without metastasis and metastasis was 14 and 8,respectively,whereas the number of patients with multiple nodes without metastasis and metastasis was 17 and 43,*** were statistically significant differences in the number of ultrasound lymph nodes and nodules,but no statistically significant differences in TR classification,enhanced CT lymph nodes,nodules distribution,and disease ***:Serum TS

关键词： Serum TSH Ultrasound CT thyroid papillary carcinoma Lymph node

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Studies on surgical methods for sporadic micromedullary thyroid carcinoma

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Oncology and Translational Medicine 2024年第4期10卷 184-189页

作者： Yaqiong Ni Xiaofeng Hou Wei Yao Tao Wang Qinjiang Liu Department of Head and Neck Surgery Sun Yat-sen University Cancer Center Gansu HospitalLanzhouGansuChina

Background:To observe the changes in serum calcitonin levels after application of different surgical methods for primary medullary thyroid microcarcinoma(MTMC)and explore a more reasonable surgical ***:A retrospective analysis of 36 patients with MTMC,16 in group A and 20 in group B,was *** group A,tumors were single and confined to the thyroid lobe,and thyroid lobectomy with isthmusectomy was *** group B,tumors were in the isthmus or invaded the thyroid gland,or there were multiple foci in bilateral lobes,and patients with primary foci underwent total *** median follow-up time was 3.6 *** and pathological characteristics and changes in serum calcitonin(CTn)and carcinoembryonic antigen levels after the surgery were compared between the 2 ***:The difference in the biochemical cure rate after surgery was statistically significant between patients with preoperative serum calcitonin levels0.05).One recurrence and metastasis were observed in each group after ***:After performing different surgical methods for the primary foci of MTMC,the changes in serum calcitonin and carcinoembryonic antigen levels are *** for patients with single foci confined to the thyroid lobe without lateral cervical lymph node metastasis and with serum calcitonin levelsthyroid lobectomy with isthmectomy can achieve the same therapeutic effect and biochemical cure rate as total thyroidectomy.

关键词： thyroid papillary carcinoma Surgery Calcitonin Carcinoembryonic antigen

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Clinicopathologic Characteristics of Differentiated thyroid carcinoma in Children and Adolescents

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Advances in Bioscience and Biotechnology 2023年第4期14卷 143-150页

作者： Tianzhi Zhang Chao Liang Guangchang Shan Danting Su Department of Pathology The Seventh Affiliated Hospital of Sun Yat-sen University Shenzhen China

Objective: To investigate the clinicopathologic features of differentiated thyroid carcinoma in children and adolescents. Methods: The clinical data of 7 children and adolescents with differentiated thyroid carcinoma were retrospectively analyzed, and the clinicopathologic features of differentiated thyroid carcinoma were analyzed by gender, tumor size and BRAF mutation. Results: There were 7 cases of thyroid papillary carcinoma. The mean age of patients was (18.71 ± 2.75), and the mean tumor diameter was (2.4 ± 1.04) cm. Lymph node metastasis rate was 100% (7/7). In children and adolescents, the lesion volume was larger, membrane invasion and vascular cancer thrombus were more likely to occur, BRAF mutation was less common, and the difference was statistically significant. Conclusion: Children and adolescents with differentiated thyroid carcinoma are more aggressive and prone to membrane invasion and lymph node metastasis;BRAF mutation is less common than in adults.

关键词： Children and Adolescents thyroid papillary carcinoma Clinicopathological Features BRAF Mutation

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A novel molecular marker in thyroid cancer: AKR1B10

A novel molecular marker in thyroid cancer: AKR1B10

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2017年中国肿瘤标志物学术大会暨第十一届肿瘤标志物青年科学家论坛

作者：郭远薇 Yu Wang Wangli Wei Jia Li Xiaojie Li Huiqiu Cao Dixian Luo Translational Medicine Institute and National & Local Joint Engineering Laboratory for High-through Molecular Diagnosis TechnologyAffiliated the First People’s Hospital of ChenzhouUniversity of South China Center for Clinical Pathology Affiliated the First People’s Hospital of ChenzhouUniversity of South China E.N.T.Department the First People’s Hospital of Chenzhou

Objective: To investigate the expression of AKR1 B10 in papillary thyroid carcinoma and the correlation between the expression levels and clinicopathological characteristics Materials and methods: Specimens and clinical data were obtained from patients with thyroid disease at the First People’s Hospital of Chenzhou from January 2013 to July 2015. There were 117 cases of thyroid papillary carcinoma(PTC), 40 cases of nodular goiter, 40 cases of follicular adenoma of thyroid, 40 cases of Hashimoto thyroiditis and 13 cases of normal thyroid tissue. The expression levels of AKR1 B10 were measured by immunohistochemistry. SPSS 18.0 statistical software was used to analyze the data. Results: 1. AKR1 B10 were detected mainly in the cytoplasm and occasionally in the nucleus. The positive rates of AKR1 B10 expression were higher in papillary thyroid carcinoma(88.0%) and hashimoto thyroiditis(82.5%) than that in nodular goiter(22.5%), thyroid follicular adenoma(32.5%),para-carcinoma tissue(28.6%)and normal thyroid tissue(38.5%). 2. The expression levels of AKR1 B10 were not significantly different between PTC and hashimoto thyroiditis(p>0.05). However, the difference of AKR1 B10 expression between PTC and other four type of begin tissues was statistically significant(p<0.05). 3. The levels of AKR1 B10 expression in PTC were positively associated with tumor size and node metastasis(p<0.05) and negatively correlated with the level of serum TSH(p<0.05). However, the expression level of AKR1 B10 in PTC was not correlated with gender, age, infiltration to adjacent tissue, site and TNM stage. Conclusion: AKR1 B10 overexpression was positively correlated with tumor size, lymph node metastasis, but negatively correlated with the level of serum TSH. AKR1 B10 might be involved in regulating the proliferation and migration of tumor cells. Therefore, AKR1 B10 might become a novel biomarker for diagnosis of treatment of PTC.

关键词： AKR1B10 thyroid papillary carcinoma metastasis

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