Clinicopathologic Characteristics of Differentiated Thyroid Carcinoma in Children and Adolescents
Clinicopathologic Characteristics of Differentiated Thyroid Carcinoma in Children and Adolescents作者机构：Department of Pathology The Seventh Affiliated Hospital of Sun Yat-sen University Shenzhen China
出 版 物：《Advances in Bioscience and Biotechnology》 (生命科学与技术进展（英文）)
年 卷 期：2023年第14卷第4期
页 面：143-150页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Children and Adolescents Thyroid Papillary Carcinoma Clinicopathological Features BRAF Mutation
摘 要：Objective: To investigate the clinicopathologic features of differentiated thyroid carcinoma in children and adolescents. Methods: The clinical data of 7 children and adolescents with differentiated thyroid carcinoma were retrospectively analyzed, and the clinicopathologic features of differentiated thyroid carcinoma were analyzed by gender, tumor size and BRAF mutation. Results: There were 7 cases of thyroid papillary carcinoma. The mean age of patients was (18.71 ± 2.75), and the mean tumor diameter was (2.4 ± 1.04) cm. Lymph node metastasis rate was 100% (7/7). In children and adolescents, the lesion volume was larger, membrane invasion and vascular cancer thrombus were more likely to occur, BRAF mutation was less common, and the difference was statistically significant. Conclusion: Children and adolescents with differentiated thyroid carcinoma are more aggressive and prone to membrane invasion and lymph node metastasis;BRAF mutation is less common than in adults.
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