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Altered thalamic subregion functional networks in patients with treatment-resistant schizophrenia

World Journal of Psychiatry 2022年第5期12卷 693-707页

作者： Woo-Sung Kim Jie Shen Uyanga Tsogt Soyolsaikhan Odkhuu Young-Chul Chung Department of Psychiatry Jeonbuk National UniversityJeon-ju 54907South Korea

BACKGROUND The thalamus plays a key role in filtering information and has extensive interconnectivity with other brain regions.A large body of evidence points to impaired functional connectivity(FC)of the thalamocortical pathway in schizophrenia.However,the functional network of the thalamic subregions has not been investigated in patients with treatment-resistant schizophrenia(TRS).AIM To identify the neural mechanisms underlying TRS,we investigated FC of thalamic sub-regions with cortical networks and voxels,and the associations of this FC with clinical symptoms.We hypothesized that the FC of thalamic subregions with cortical networks and voxels would differ between TRS patients and HCs.METHODS In total,50 patients with TRS and 61 healthy controls(HCs)matched for age,sex,and education underwent resting-state functional magnetic resonance imaging(rs-fMRI)and clinical evaluation.Based on the rs-fMRI data,we conducted a FC analysis between thalamic subregions and cortical functional networks and voxels,and within thalamic subregions and cortical functional networks,in the patients with TRS.A functional parcellation atlas was used to segment the thalamus into nine subregions.Correlations between altered FC and TRS symptoms were explored.RESULTS We found differences in FC within thalamic subregions and cortical functional networks between patients with TRS and HCs.In addition,increased FC was observed between thalamic subregions and the sensorimotor cortex,frontal medial cortex,and lingual gyrus.These abnormalities were associated with the pathophysiology of TRS.CONCLUSION Our findings suggest that disrupted FC within thalamic subregions and cortical functional networks,and within the thalamocortical pathway,has potential as a marker for TRS.Our findings also improve our understanding of the relationship between the thalamocortical pathway and TRS symptoms.

关键词： Treatment-resistant schizophrenia thalamus Rs-fMRI Functional connectivity Thalamocortical pathway

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Increased thalamocortical connectivity from the affected thalamus to the unaffected hemisphere in a stroke patient

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Neural Regeneration Research 2020年第8期15卷 1568-1568页

作者： Sung Ho Jang You Sung Seo Sung Jun Lee Department of Physical Medicine and Rehabilitation College of MedicineYeungnam University

Consciousness is controlled by complicated actions of various neural structures(Schiff,2010;Long et al.,2016).The thalamocortical connections between the central thalamus and cerebral cortex are considered an important neural structure for consciousness(Laureys et al.,2000;Schiff,2010;Jang and Lee,2015).Here,we report a patient who revealed increased thalamocortical connectivity from the affected thalamus to the unaffected hemisphere through interthalamic adhesion.

关键词： al. patient thalamus

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Cortico-centric effects of general anesthetics on cerebrocortical evoked potentials

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Neuroscience Bulletin 2015年第6期31卷 697-704页

作者： Logan J.Voss James W.Sleigh Anaesthesia Department Waikato District Health Board University of Auckland Waikato Clinical School

Despite their ubiquitous use for rendering patients unconscious for surgery, our understanding of how general anesthetics cause hypnosis remains rudimentary at best. Recent years have seen increased interest in ＂top-down＂ cortico-centric theories of anesthetic action. The aim of this study was to explore this by investigating direct cortical effects of anesthetics on cerebrocortical evoked potentials in isolated mouse brain slices. Evoked potentials were elicited in cortical layer IV by electrical stimulation of the underlying white matter. The effects of three anesthetics （ketamine, etomidate, and isoflurane） on the amplitude, latency, and slope of short-latency evoked potentials were quantified. The N2/P3/N4 potentials - which represent the early cortical response - were enhanced by etomidate （increased P3-N4 slope, P 〈0.01）, maintained by ketamine, and reduced by isoflurane （lower N2/P3 amplitude, P 〈0.01）. These effects closely resemble those seen in vivo for the same drugs and point to a cortical mechanism independent of effects on subcortical structures such as the thalamus.

关键词： anesthesia evoked potentials corticalslice thalamus

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Three-Dimensional Heterogeneity of Cerebellar Interposed Nucleus-Recipient Zones in the Thalamic Nuclei

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Neuroscience Bulletin 2021年第11期37卷 1529-1541页

作者： Kuang-Yi Ma Xin-Yu Cai Xin-Tai Wang Zhao-Xiang Wang Wan-Meng Huang Zhi-Ying Wu Zhou-Yan Feng Ying Shen Department of Physiology and Department of Neurology of the First Affiliated Hospital Zhejiang University School of MedicineHangzhou310058China Key Laboratory of Biomedical Engineering of the Ministry of Education College of Biomedical Engineering and Instrumentation ScienceZhejiang UniversityHangzhou310013China Department of Neurology and Research Center of Neurology in the Second Affiliated Hospital and Key Laboratory of Medical Neurobiology of Zhejiang ProvinceZhejiang University School of MedicineHangzhou310058China

The cerebellum is conceptualized as a processor of complex movements and is also endowed with roles in cognitive and emotional behaviors.Although the axons of deep cerebellar nuclei are known to project to primary thalamic nuclei,macroscopic investigation of the characteristics of these projections,such as the spatial distribution of recipient zones,is lacking.Here,we studied the output of the cerebellar interposed nucleus(IpN)to the ventrolateral(VL)and centrolateral(CL)thalamic nuclei using electrophysiological recording in vivo and trans-synaptic viral tracing.We found that IpN stimulation induced mono-synaptic evoked potentials(EPs)in the VL but not the CL region.Furthermore,both the EPs induced by the IpN and the innervation of IpN projections displayed substantial heterogeneity across the VL region in three-dimensional space.These findings indicate that the recipient zones of IpN inputs vary between and within thalamic nuclei and may differentially control thalamo-cortical networks.

关键词： Cerebellum thalamus Interposed nucleus Ventrolateral nucleus Trans-synaptic tracing

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Comparison of numbers of interneurons in three thalamic nuclei of normal and epileptic rats

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Neuroscience Bulletin 2014年第3期30卷 451-460页

作者： Safiye avdar Hüsniye Hacioglu Bay Sercan D.Yildiz Dilek Akakin Serap Sirvanci Filiz Onat Department of Anatomy School of Medicine Ko University Department of Anatomy School of Medicine Marmara University Department of Histology and Embryology School of Medicine Marmara University Department of Pharmacology and Clinical Pharmacology School of Medicine Marmara University

The inhibitory sources in the thalamic nuclei are local interneurons and neurons of the thalamic reticular nucleus. Studies of models of absence epilepsy have shown that the seizures are associated with an excess of inhibitory neurotransmission in the thalamus. In the present study, we used light- microscopic gamma-aminobutyric acid （GABA） immunocytochemistry to quantify the interneurons in the lateral geniculate （LGN）, ventral posteromedial （VPM）, and ventral posterolateral （VPL） thalamic nuclei, and compared the values from normal Wistar rats and genetic absence epilepsy rats from Strasbourg （GAERS）. We found that in both Wistar rats and GAERS, the proportion of interneurons was significantly higher in the LGN than in the VPM and VPL. In the LGN of Wistar rats, 16.4% of the neurons were interneurons and in the GAERS, the value was 15.1%. In the VPM, the proportion of interneurons was 4.2% in Wistar and 14.9% in GAERS; in the VPL the values were 3.7% for Wistar and 11.1% for the GAERS. There was no significant difference between Wistar rats and the GAERS regarding the counts of interneurons in the LGN, whereas the VPM and VPL showed significantly higher counts in GAERS. Comparison of the mean areas of both relay cells and interneuronal profiles showed no significant differences between Wistar rats and GAERS. These findings show that in the VPL and the VPM there are relatively more GABAergic interneurons in GAERS than in Wistar rats. This may represent a compensatory response of the thalamocortical circuitry to the absence seizures or may be related to the production of absence seizures.

关键词： immunohistochemistry interneuron relay neuron thalamus GABA

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Regional volume changes of the brain in migraine chronification

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Neural Regeneration Research 2020年第9期15卷 1701-1708页

作者： Xiao-Yan Chen Zhi-Ye Chen Zhao Dong Meng-Qi Liu Sheng-Yuan Yu Department of Neurology First Medical Center of Chinese PLA General HospitalBeijingChina Department of Radiology First Medical Center of Chinese PLA General HospitalBeijingChina Department of Radiology Hainan Hospital of First Medical Center of Chinese PLA General HospitalSanyaHainan ProvinceChina

The pathophysiology of migraine is complex.Neuroimaging studies reveal functional and structural changes in the brains of migraine patients.We sought to explore regional volume differences in intracranial structures in patients with episodic and chronic migraine.Sixteen episodic migraine patients,16 chronic migraine patients,and 24 normal controls were recruited and underwent 3.0 T MRI scanning.The volumes of 142 brain regions were calculated by an automatic volumetric algorithm and compared with clinical variables.Results demonstrated that the volumes of specific regions in the frontal and occipital lobes,and the right putamen,were increased and the volume of the fourth ventricle was decreased in the episodic migraine patients compared with controls.The volumes of the left basal forebrain,optic chiasm,and,the fourth ventricle were decreased in the chronic migraine patients,while the occipital cortex and the right putamen were larger.Compared to episodic migraine patiants,chronic migraine patients displayed larger left thalamus and smaller frontal regions.Correlation analysis showed that headache frequency was negatively correlated with the volume of the right frontal pole,right lateral orbital gyrus,and medial frontal lobes and positively correlated with the volume of the left thalamus.The sleep disturbance score was negatively correlated with the volume of the left basal forebrain.This suggests that migraine patients have structural changes in regions associated with pain processing and modulation,affective and cognitive processing,and visual perception.The remodeling of selective intracranial structures may be involved in migraine attacks.This study was approved by the Ethics Committee of Chinese PLA General Hospital(approval No.S2018-027-02)on May 31,2018.

关键词： brain volume chronic migraine frontal lobe magnetic resonance imaging migraine remodeling thalamus visual processing system

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Hippocampal and thalamic neuronal metabolism in a putative rat model of schizophrenia°

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Neural Regeneration Research 2013年第26期8卷 2415-2423页

作者： Guolin Ma Tianbin Song Min Chen Yuan Fu Yong Xu Ensen Ma Wu Wang Jiang Du Mingxiong Huang Department of Radiology China-Japan Friendship Hospital Department of Radiology Beijing Shunyi Hospital Department of Radiology Beijing Hospital Affiliated to the Ministry of Public Health Department of Mental Health First Hospital of Shanxi Medical University Department of Radiology University of California Radiology Imaging Laboratory Department of Radiology University of California

The transcription factor early growth response protein 3 （EGR3） is involved in schizophrenia. We developed a putative rat model of schizophrenia by transfecting lentiviral particles carrying the Egr3 gene into bilateral hippocampal dentate gyrus. We assessed spatial working memory using the Morris water maze test, and neuronal metabolite levels in bilateral hippocampus and thalamus were determined by 3.0 T proton magnetic resonance spectroscopy. Choline content was significantly greater in the hippocampus after transfection, while N-acetylaspartate and the ratio of N-acetylaspartate to creatine/phosphocreatine in the thalamus were lower than in controls. This study is the first to report evaluation of brain metabolites using 3,0 T proton magnetic resonance spectroscopy in rats transfected with Egr3, and reveals metabolic abnormalities in the hippocampus and thalamus in this putative model of schizophrenia.

关键词： neural regeneration neuroimaging schizophrenia proton magnetic resonance spectroscopy early growth response protein 3 hippocampus thalamus gene neuroregeneration

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Expert Consensus on Clinical Diagnostic Criteria for Fatal Familial Insomnia

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Chinese Medical Journal 2018年第13期131卷 1613-1617页

作者： Li-Yong Wu Shu-Qin Zhan Zhao-Yang Huang Bin Zhang Tao Wang Chun-Feng Liu Hui Lu Xiao-Ping Dong Zhi-Ying Wu Jie-Wen Zhang Ji-Hui Zhang Zhong-Xin Zhao Fang Han Yah Huang Jun Lu Serge Gauthier Jian-Ping Jia Yu-Ping Wang Department of Neurology Xuan Wu Hospital Capital Medical University Belling 100053 China Department of Psychiatry Nanfang Hospital Southern Medical University Guangzhou Guangdong 510515 China Department of Neurology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei 430022 China Department of Neurorogy Second Affiliated Hospital of Soochow University Suzhou Jiangsu 215004 China State Key Laboratory for Infectious Disease Prevention and Control National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing 100050 China Department of Neurology and Research Center of Neurology Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang 310009 China Department of Neurology Henan Provincial People's Hospital Zhengzhou Henan 450003 China Department of Psychiatry Faculty of Medicine The Chinese University of Hong Kong Shatin NT Hong Kong SAR 000000 China Department of Neurology Changzheng Hospital The Second Military Medical University Shanghai 200003 China Department of Respiratory Medicine Peking University People's Hospital Beijing 100044 China Department of Neurology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China Department of Neurology Program in Neuroscience and Division of Sleep Medicine Harvard Medical School and Beth Israel Deaconess Medical Center Boston 02215 MA USA McGill Centre for Studies in Aging Alzheimer's Disease Research Unit Montreal H4H 1R3 Canada

INTRODUCTION Fatal familial insomnia （FFI） is a serious and rare prion disease, which was first reported by Lugaresi et al. in 1986.Early diagnosis of FFI might be important for early and sufficient counseling of patients and their relatives, also concerning the risk of inheritance, and potentially also for treatment studies. However, the diagnosis of FFI might be difficult because of the heterogeneity of clinical features, low sensitivity of diagnostic tests, and absence of family history. The aim of the present study was to develop a clinical scheme and diagnostic criteria for FFI based on our research and expert consensus.

关键词： HUMAN PRION DISEASES CREUTZFELDT-JAKOB-DISEASE PROTEIN NEUROPATHOLOGY DEGENERATION FEATURES DISORDERS thalamus MUTATION ONSET

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Effects of bilateral subthalamic nucleus deep brain stimulation on motor symptoms in Parkinson’s disease: a retrospective cohort study

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Neural Regeneration Research 2021年第5期16卷 905-909页

作者： Guo-Xiong Cheng Shu-Bin Yin Ying-Hao Yang Yuan-Hu Hu Chih-Yang Huang Qian-Ming Yao Wei-Jen Ting Deparment of Neurosurgery The First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Deparment of Neurosurgery The Sixth Affiliated Hospital of Guangzhou Medical UniversityQingyuanGuangdong ProvinceChina Graduate Institute of Basic Medical Science China Medical UniversityTaichungTaiwanChina Department of Health and Nutrition Biotechnology Asia UniversityTaichungTaiwanChina College of Medicine Hualien Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationTzu Chi UniversityHualienTaiwanChina Medical Research Center for Exosome and Mitochondria Related Diseases China Medical University and HospitalTaichungTaiwanChina

Deep brain stimulation of the bilateral subthalamic nucleus(STN)is a therapeutic option for patients with Parkinson’s disease(PD)in whom medical therapies have been ineffective.This retrospective cohort study analyzed the motor function of 27 patients with advanced PD,from the First Affiliated Hospital of Guangzhou Medical University,China,who received deep brain stimulation of the bilateral subthalamic nucleus and evaluated its therapeutic effects.The 10-year follow-up data of patients was analyzed in Qingyuan People’s Hospital,Sixth Affiliated Hospital of Guangzhou Medical University,China.The follow-up data were divided into two categories based on patients during levodopa treatment(on-medication)and without levodopa treatment(off-medication).Compared with baseline,the motor function of onmedication PD patients improved after deep brain stimulation of the bilateral subthalamic nucleus.Even 2 years later,the motor function of off-medication PD patients had improved.On-medication PD patients exhibited better therapeutic effects over the 5 years than offmedication PD patients.On-medication patients’akinesia,speech,postural stability,gait,and cognitive function worsened only after 5 years.These results suggest that the motor function of patients with advanced PD benefitted from treatment with deep brain stimulation of the bilateral subthalamic nucleus over a period up to 5 years.The overall therapeutic effects were more pronounced when levodopa treatment was combined with deep brain stimulation of the bilateral subthalamic nucleus.This study was approved by Institutional Review Board of Qingyuan People’s Hospital,The Sixth Affiliated Hospital of Guangzhou Medical University,China(approval No.QPH-IRB-A0140)on January 11,2018.

关键词： clinical trial deep brain stimulation dopamine dyskinesia levodopa long-term follow-up neurological function Parkinson’s disease thalamus UPDRS

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Brain glucose metabolic changes associated with chronic spontaneous pain due to brachial plexus avulsion： a preliminary positron emission tomography study

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Chinese Medical Journal 2008年第12期121卷 1096-1100页

作者： CHEN Fu-yong TAO Wei CHENG Xin WANG Hong-yan HU Yong-sheng ZHANG Xiao-hua LI Yong-jie Beijing Institute of Functional Neurosurgery Xuanwu Hospital Capital Medical University Beijing 100053 China Positron Emission Tomography Center Xuanwu Hospital Capital Medical University Beijing 100053 China Positron Emission Tomography Center Peking Union Medical College Hospital Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100730 China

Background Previous brain imaging studies suggested that the brain activity underlying the perception of chronic pain may differ from that underlying acute pain. To investigate the brain regions involved in chronic spontaneous pain due to brachial plexus avulsion （BPA）, fluorine-18^fluorodeoxyglucose （18^F-FDG） positron emission tomography （PET） scanning was applied to determine the glucose metabolic changes in patients with pain due to BPA.Methods Six right-handed patients with chronic spontaneous pain due to left-BPA and twelve right-handed age- and sex-matched healthy control subjects participated in the 18^F-FDG PET study. The patients were rated by visual analog scale （VAS） during scanning and Hamilton depression scale and Hamilton anxiety scale after scanning. Statistical parametric mapping 2 （SPM2） was applied for data analysis. Results Compared with healthy subjects, the patients had significant glucose metabolism decreases in the right thalamus and SI （P 〈0.001, uncorrected）, and significant glucose metabolism increases in the right orbitofrontal cortex （OFC）（BAll）, left rostral insula cortex and left dorsolateral prefrontal cortex （DLPFC）（BA10/46）（P 〈0.001, uncorrected）. Conclusion These findings suggest that the brain areas involved in emotion, attention and internal modulation of pain may be related to the chronic spontaneous pain due to BPA.

关键词： neuropathic pain positron emission tomography brachial plexus avulsion orbitofrontal cortex thalamus

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