Expert Consensus on Clinical Diagnostic Criteria for Fatal Familial Insomnia

作     者：Li-Yong Wu Shu-Qin Zhan Zhao-Yang Huang Bin Zhang Tao Wang Chun-Feng Liu Hui Lu Xiao-Ping Dong Zhi-Ying Wu Jie-Wen Zhang Ji-Hui Zhang Zhong-Xin Zhao Fang Han Yah Huang Jun Lu Serge Gauthier Jian-Ping Jia Yu-Ping Wang Wu Li-Yong;Zhan Shu-Qin;Huang Zhao-Yang;Zhang Bin;Wang Tao;Liu Chun-Feng;Lu Hui;Dong Xiao-Ping;Wu Zhi-Ying;Zhang Jie-Wen;Zhang Ji-Hui;Zhao Zhong-Xin;Han Fang;Huang Yan;Lu Jun;Gauthier Serge;Jia Jian-Ping;Wang Yu-Ping

作者机构：Department of Neurology Xuan Wu Hospital Capital Medical University Belling 100053 China Department of Psychiatry Nanfang Hospital Southern Medical University Guangzhou Guangdong 510515 China Department of Neurology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei 430022 China Department of Neurorogy Second Affiliated Hospital of Soochow University Suzhou Jiangsu 215004 China State Key Laboratory for Infectious Disease Prevention and Control National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing 100050 China Department of Neurology and Research Center of Neurology Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang 310009 China Department of Neurology Henan Provincial People's Hospital Zhengzhou Henan 450003 China Department of Psychiatry Faculty of Medicine The Chinese University of Hong Kong Shatin NT Hong Kong SAR 000000 China Department of Neurology Changzheng Hospital The Second Military Medical University Shanghai 200003 China Department of Respiratory Medicine Peking University People's Hospital Beijing 100044 China Department of Neurology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China Department of Neurology Program in Neuroscience and Division of Sleep Medicine Harvard Medical School and Beth Israel Deaconess Medical Center Boston 02215 MA USA McGill Centre for Studies in Aging Alzheimer's Disease Research Unit Montreal H4H 1R3 Canada 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2018年第131卷第13期

页      面：1613-1617页

核心收录：

学科分类：1002[医学-临床医学] 10[医学] 

基　　金：This work was supported by grants from the National Natural Science Foundation of China (No. 81470074)  and the Clinical funding from Beijing Municipal Science and Technology Committee (No.Z141107002514117) 

主　　题：HUMAN PRION DISEASES CREUTZFELDT-JAKOB-DISEASE PROTEIN NEUROPATHOLOGY DEGENERATION FEATURES DISORDERS THALAMUS MUTATION ONSET 

摘      要：INTRODUCTION Fatal familial insomnia （FFI） is a serious and rare prion disease, which was first reported by Lugaresi et al. in *** diagnosis of FFI might be important for early and sufficient counseling of patients and their relatives, also concerning the risk of inheritance, and potentially also for treatment studies. However, the diagnosis of FFI might be difficult because of the heterogeneity of clinical features, low sensitivity of diagnostic tests, and absence of family history. The aim of the present study was to develop a clinical scheme and diagnostic criteria for FFI based on our research and expert consensus.