Altered thalamic subregion functional networks in patients with treatment-resistant schizophrenia
作者机构：Department of PsychiatryJeonbuk National UniversityJeon-ju 54907South Korea
出 版 物：《World Journal of Psychiatry》 (世界精神病学杂志)
年 卷 期：2022年第12卷第5期
页 面：693-707页
核心收录：
学科分类：1002[医学-临床医学] 100205[医学-精神病与精神卫生学] 10[医学]
基 金：Supported by the Korean Mental Health Technology R&D Project,Ministry of Health&Welfare,Republic of Korea,No.HL19C0015 the Korea Health Technology R&D Project through the Korea Health Industry Development Institute funded by the Ministry of Health&Welfare,Republic of Korea,No.HR18C0016
主 题：Treatment-resistant schizophrenia Thalamus Rs-fMRI Functional connectivity Thalamocortical pathway
摘 要：BACKGROUND The thalamus plays a key role in filtering information and has extensive interconnectivity with other brain regions.A large body of evidence points to impaired functional connectivity(FC)of the thalamocortical pathway in ***,the functional network of the thalamic subregions has not been investigated in patients with treatment-resistant schizophrenia(TRS).AIM To identify the neural mechanisms underlying TRS,we investigated FC of thalamic sub-regions with cortical networks and voxels,and the associations of this FC with clinical *** hypothesized that the FC of thalamic subregions with cortical networks and voxels would differ between TRS patients and *** In total,50 patients with TRS and 61 healthy controls(HCs)matched for age,sex,and education underwent resting-state functional magnetic resonance imaging(rs-fMRI)and clinical *** on the rs-fMRI data,we conducted a FC analysis between thalamic subregions and cortical functional networks and voxels,and within thalamic subregions and cortical functional networks,in the patients with TRS.A functional parcellation atlas was used to segment the thalamus into nine *** between altered FC and TRS symptoms were *** We found differences in FC within thalamic subregions and cortical functional networks between patients with TRS and *** addition,increased FC was observed between thalamic subregions and the sensorimotor cortex,frontal medial cortex,and lingual *** abnormalities were associated with the pathophysiology of *** Our findings suggest that disrupted FC within thalamic subregions and cortical functional networks,and within the thalamocortical pathway,has potential as a marker for *** findings also improve our understanding of the relationship between the thalamocortical pathway and TRS symptoms.
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