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Huoxue Tongjiang decoction-resisted reflux esophagitis by activation stem cell factor/c-kit/interstitial cell of cajal pathway and regulating the T-helper 17/regulatory T-cells balance in rats

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Traditional Medicine Research 2024年第12期9卷 1-12页

作者： Yan Liu Yan-Ping Tang Pei-Cai Li Lei Liu Xi Liu Si-Yu Liu Lei Yang Division of Gastroenterology Hospital of Integrated Chinese and Western MedicineTianjin University of Traditional Chinese MedicineTianjin 300000China Tianjin Key Laboratory of Acute Abdomen Disease Associated Organ Injury and ITCWM Repair Hospital of Integrated Chinese and Western MedicineTianjin 300000China Institute of Integrative Medicine for Acute Abdominal Diseases Hospital of Integrated Chinese and Western MedicineTianjin 300000China

Background:Huoxue Tongjiang decoction(HXTJD)is an effective prescription for treating reflux esophagitis(RE).We investigated the effects of HXTJD on esophageal motility and mucosal inflammation in a rat RE ***:Chemical composition of HXTJD was analyzed by ultrahigh-performance liquid chromatography Q-Orbitrap mass spectrometry(MS).the change rates of mean contraction tension forces,mean amplitudes,and mean frequencies for the lower esophageal sphincter(LES)were recorded using the isolated tissue bath system,mechanical tension transducer,and PowerLab physiological *** weighing the stomach,the phenol red labeling method was used to measure the gastric emptying *** LES ultrastructure was observed through transmission electron *** and western blotting were used to detect the number of interstitial cells of Cajal(ICC)and the expression levels of c-kit protein,connexin43(Cx43),and stem cell factor(SCF).Flow cytometric analysis and enzyme-linked immunosorbent assay were conducted to detect the percentages of T helper 17(th17)cells and regulatory T(treg)cells and the serum concentrations of interleukin 6(IL-6),interleukin 17(IL-17),and interleukin 10(IL-10)in the ***:We identified 28 chemical constituents in *** esophageal motility,we revealed that HXTJD increased the mean contraction tension forces,mean amplitudes,and mean frequency change rate of LES and the gastric emptying rate;decreased stomach weight;and improved the LES ***,HXTJD increased the number of ICC-positive cells,and c-kit,Cx43,and SCF expression *** esophageal inflammation,HXTJD significantly decreased the percentage of th17 cells,and IL-6 and IL-17 concentrations,and increased the percentage of treg cells and IL-10 ***:HXTJD was found to be efficacious in the rat RE *** may promote esophageal motility and alleviate the inflammatory response by activating the SCF/c-kit/ICC

关键词： Huoxue Tongjiang decoction reflux esophagitis SCF/c-kit/ICC pathway th17/treg cell esophageal motility mucosal inflammation

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Effect of saikosaponin A on treg and th17 immune balance in depressive rats

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Journal of Hainan Medical University 2020年第22期26卷 6-9页

作者： Xu-Tong Guo Ji-Dong An Jian-Qiang Mei Emergency department of Hebei Hospital of traditional Chinese Medicine

Objective:To investigate the Effect of saikosaponin A on treg and th17 immune balance in depressive ***:the rat depression model was established with reference to the Katz method,and the rats were randomly divided into control group,model group,western medicine group,and saikosaponin A *** western medicine group was given 1.2 mg/kg/d of fluoxetine,and the saikosaponin A group was given 25 mg/kg/d of saikosaponin A,while the control group and model group were given the same volume of normal *** evaluation of depression in Rats was analyzed by Openfield-test and sugar water preference *** cytometry was used to detect the expression of th17 and treg *** the expression of IL-17,IL-23,TNF-α,IL-10,TGF-βwere detected by enzyme-linked immunosorbent assay(ELISA).Results:Compared with the control group,the horizontal exercise score,vertical exercise score,and sugar preference of the model group decreased significantly(Pth the model group,the above indicators were significantly increased in the western medicine group and saikosaponin A group(Pthat compared with the control group,the th17 cells,th17/treg cell ratio in model group increased significantly,whereas the treg cells decreased significantly(Pth the model group,the th17 cells and th17/treg ratio in western medicine group and saikosaponin A group decreased,while the treg cells increased significantly(Pthat compared with control group,the serum levels of IL-17,IL-23 and TNF-αin model group increased,while the levels of IL-10 and TGF-βdecreased(Pth model group,the levels of IL-17,IL-23 and TNF-αdecreased,while the levels of IL-10 and TGF-βincreased in western medicine group and saikosaponin A group(Pthe degree of depression by regulating the imbalance of th17/treg cells and the secretion of inflammatory cytokines in depressed rats.

关键词： Saikosaponin A Depression th17/treg cell Cytokines

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