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Nanosuspension enhances dissolution rate and oral bioavailability of terminalia arjuna bark extract in vivo and in vitro

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Asian Pacific Journal of Tropical Biomedicine 2020年第4期10卷 164-171页

作者： Fatiqa Zafar Nazish Jahan Khalil-Ur-Rahman Muhammad Rafique Asi Waseeq-Ul-Islam Zafar Department of Chemistry University of OkaraOkaraPakistan Department of Chemistry University of AgricultureFaisalabadPakistan Department of Biochemistry University of AgricultureFaisalabadPakistan Food Toxicology Lab Plant Protection DivisionNuclear Institute for Agriculture and BiologyFaisalabadPakistan Department of Computer Science COMSATS University of Information and TechnologyIslamabadPakistan

Objective:To enhance the dissolution rate and oral bioavailability of terminalia arjuna bark extract by formulating its ***:Nanoprecipitation approach was used for the formulation of nanosuspension using polysorbate-80 as a *** formulated nanosuspension was assessed for particle size,polydispersity index,zeta potential value and for in vitro dissolution *** bioavailability studies were carried out in Wistar male albino rats by administering a single dose(50 mg/***)of the formulated nanosuspension and coarse *** storage stability of the formulated nanosuspension was determined after three months of storage at room temperature and under the refrigerated *** assay was carried out to evaluate the toxicity of the formulated nanosuspension using two mutant strains(Salmonella typhimurium TA100 and Salmonella typhimurium TA98).Results:The mean particle size of the formulated nanosuspension was 90.53 nm with polydispersity index and zeta potential values of 0.175 and-15.7 m V,*** arjuna nanosuspension showed improved dissolution rate and 1.33-fold higher oral bioavailability than its coarse *** formulated nanosuspension also showed better stability under the refrigerated condition and was non-mutagenic against both ***:Our study demonstrates that nanosuspension technology can effectively enhance the dissolution rate and oral bioavailability of terminalia arjuna bark extract.

关键词： terminalia arjuna Nanosuspension Bioavailability Stability Toxicity Polysorbate-80

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Hepatoprotective activity of terminalia paniculata against paracetamol induced hepatocellular damage in Wistar albino rats

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Asian Pacific Journal of Tropical Medicine 2011年第6期4卷 466-469页

作者： Eesha BR Mohanbabu Amberkar V Meena Kumari K Sarath babu Vijay M Lalit M Rajput R Department of Pharmacology Kasturba Medical CollegeManipal UniversityKarnatakaIndia

Objective:To evaluate the hepatoprotective activity of terminalia paniculata against paracetamol induced hepatic damage in ***:The plant material was shade dried, powdered and extracted with *** 52 and silymarin were used as standard drugs and 2%gum acacia as a control(vehicle).Alteration in the levels of biochemical markers of hepatic damage like AST,ALT,ALP and lipid peroxides were tested,and phytochemical tests were also ***:Paracetamol(2 g/kg) increased the serum levels of alanine aminotransfer (ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP) and the lipid peroxides. Treatment of Liv 52,silymarin and ethanolic extract of terminalia paniculata(200 mg/kg) altered levels of biochemical marker and showed significant hepatoprotective *** extract revealed the presence of phenolic compound and *** findings suggested that ethanolic bark extract of terminalia paniculata possessed hepatoprotective activity in a dose dependent ***:terminalia paniculata possesses hepatoprotective *** could be an effective and promising preventive agent against PCT induced hepatotoxicity.

关键词： terminalia paniculata Hepatoprotection Paracetamol Liv 52 Silymarin

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Antioxidant and antimutagenic activities of bark extract of terminalia arjuna

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Asian Pacific Journal of Tropical Medicine 2010年第12期3卷 965-970页

作者： Gollapalle Lakshminarayana shastry Viswanatha Santosh Kumar Vaidya Ramesh C Nandakumar Krishnadas Srinath Rangappa Department of Pharmacology PES College of PharmacyBangalore-560050 India Department of Pharmacology St.John's College of PharmacyBangalore-560040 India Department of Pharmacology Manipal College of Pharmaceutical SciencesManipal-576104 India

Objective:The alcoholic extract of stem bark of terminalia arjuna（ALTA） was screened for antioxidant and antimutagenic（anticlastogenic） ***:Antioxidant property was determined by l,l,Diphynyl,2-Picryl hydrazyl（DPPH） assay,super oxide radical scavenging activity,lipid peroxidation assay and total polyphenolic content was determined by Folin-Ciocalteau’s *** activity was evaluated using micronucleus test in mice. Results:The ALTA has shown potent antioxidant activity with EC50 of 2.491±0.160,50.110±0.150 & 71.000±0.250 in DPPH assay,superoxide radical scavenging activity and lipid peroxidation assay, which is comparable with ascorbic acid with EC50 of 2.471±0.140,40.500±0.390 and 63.000±0.360 *** micronucleus test,ALTA（100 & 200 mg/kg,p.o.） showed significant reduction in percentage of micronucleus in both polychromatic erythrocytes（PCE） and normochromatie erythrocytes（NCE） and also shown significant reduction in P/N ***:These results suggested that ALTA possess significant antioxidant and antimutagenic activity.

关键词： terminalia arjuna Antioxidant activity Antimutagenic activity Micronuclease test

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The development of terminalia chebula Retz.(Combretaceae) in clinical research

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Asian Pacific Journal of Tropical Biomedicine 2013年第3期3卷 244-252页

作者： Anwesa Bag Subir Kumar Bhattacharyya Rabi Ranjan Chattopadhyay Agricultural and Ecological Research Unit Indian Statistical Institute 203

Medicinal plants are part and parcel of human society to combat diseases from the dawn of *** chebula Retz.(***),is called the‘King of Medicine??in Tibet and is always listed at the lop of the list of‘Ayurvedic Materia Medica??because of its extraordinary power of *** whole plant possesses high medicinal value and traditionally used for the treatment of various ailments for human *** of the folklore people used this plant in the treatment of asthma,sore throat,vomiting,hiccough,diarrhea,dysentery,bleeding piles,ulcers,gout,heart and bladder *** plant has been demonstrated to possess multiple pharmacological and medicinal activities,such as antioxidant,antimicrobial,antidiabetic,hepatoprotective,anti-inflammatory,antimutagenic,antiproliferative,radioprotective,cardioprotective,antiarthritic,anticaries,gastrointestinal motility and wound healing *** no systematic updated information on the therapeutic effectiveness of terminalia chebula,a popular herbal remedy in India and South-East Asia has so far been *** review highlights an updated information particularly on the phytochemistry and various pharmacological and medicinal properties of terminalia chebula *** some of its isolated compounds,along with their safety *** may provide incentive for proper evaluation of the plant as medicinal agent against the human diseases and also to bridge the lacunae in the existing literature and future scope which may offer immense opportunity for researchers engaged in validation of the traditional claims and development of safe and effective botanical medicine.

关键词： terminalia chebula Human diseases Medicinal value Bioactive constituents Safety evaluation

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The Genus terminalia(Combretaceae):An Ethnopharmacological,Phytochemical and Pharmacological Review

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Natural Products and Bioprospecting 2019年第6期9卷 357-392页

作者： Xiao-Rui Zhang Joseph Sakah Kaunda Hong-Tao Zhu Dong Wang Chong-Ren Yang Ying-Jun Zhang State Key Laboratory of Phytochemistry and Plant Resources in West China.Kunming Institute of Botany Chinese Academy of SciencesKunming 650204People’s Republic of China University of Chinese Academy of Sciences Beijing 100049People’s Republic of China Yunnan Key Laboratory of Natural Medicinal Chemistry Kunming Institute of BotanyChinese Academy of SciencesKunming 650201People’s Republic of China

terminalia Linn,a genus of mostly medium or large trees in the family Combretaceae with about 250 species in the world,is distributed mainly in southern Asia,Himalayas,Madagascar,Australia,and the tropical and subtropical regions of *** species are used widely in many traditional medicinal systems,e.g.,traditional Chinese medicine,Tibetan medicine,and Indian Ayurvedic medicine *** far,about 39 species have been phytochemically studied,which led to the identification of 368 compounds,including terpenoids,tannins,flavonoids,phenylpropanoids,simple phenolics and so *** of the isolates showed various bioactivities,in vitro or in vivo,such as antitumor,anti HIV-1,antifungal,antimicrobial,antimalarial,antioxidant,diarrhea and *** review covers research articles from 1934 to 2018,retrieved from SciFinder,Wikipedia,Google Scholar,Chinese Knowledge Network and Baidu Scholar by using“terminalia”as the search term(“all fields”)with no specific time frame setting for the ***-nine important medicinal and edible terminalia species were selected and summarized on their geographical distribution,traditional uses,phytochemistry and related pharmacological activities.

关键词： terminalia Combretaceae Ethnomedicine Traditional uses Phytochemistry Hydrolyzable tannins Pharmacology

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Investigation of hypoglycemic,hypolipidemic and antioxidant activities of aqueous extract of terminalia paniculata bark in diabetic rats

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Asian Pacific Journal of Tropical Biomedicine 2012年第4期2卷 262-268页

作者： Subramaniam Ramachandran Aiyalu Rajasekaran KT Manisenthilkumar Department of Pharmacology KMCH College of Pharmacy Department of Pharmaceutical Chemistry KMCH College of Pharmacy

Objective:To investigate the hypoglycemic,hypolipidemic and antioxidant activities of aqueous extract of terminalia paniculata bark(AETPB) in streptozotocin(STZ)-mduced diabetic ***:Acute toxicity was studied in rats after the oral administration of AETPB to determine the dose to assess hypoglycemic *** rats,diabetes was induced by injection of STZ(60 mg/kg,i.p.) and diabetes was confirmed 72 h after induction,and then allowed for 14 days to stabilize blood glucose *** diabetic rats,AETPB was orally given for 28 days and its effect on blood glucose and body weight was determined on a weekly *** the end of the experimental day,fasting blood sample was collected to estimate the haemoglobin(Hb),glycosylated haemoglobin(HbA1c),serum creatinine,urea,serum glutamate-pyruvate transaminase(SGPT),serum glutamate-oxaloacetate transaminase(SGOT) and insulin levels. The liver and kidney were collected to determine antioxidants levels in diabetic ***: Oral administration of AETPB did not exhibit toxicity and death at a dose of 2000 mg/*** treated diabetic rats significantly(P<0.001,P<0.01 and P<0.05) reduced elevated blood glucose, HbAlc,creatinine,urea,SGPT and SGOT levels when compared with diabetic control *** body weight,Hb,insulin and total protein levels were significantly(P<0.001,P<0.01 and P<0.05) increased in diabetic rats treated with AETPB compared to diabetic control *** diabetic rats, AETPB treatment significantly reversed abnormal status of antioxidants and lipid profile levels towards near normal levels compared to diabetic control ***:Present study results confirm that AETPB possesses significant hypoglycemic,hypolipidemic and antioxidant activities in diabetic condition.

关键词： Hypoglycemic Streptozotocin terminalia paniculata Hypolipidemic Antioxidant Diabetic Antidiabetic activity Blood glucose SGPT SGOT Insulin Haemoglobin Antioxidant activity

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In vitro anti oxidant activity and acute oral toxicity of terminalia paniculata bark ethanolic extract on Sprague Dawley rats

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Asian Pacific Journal of Tropical Biomedicine 2014年第4期4卷 294-298页

作者： Ramgopal Mopuri Balaji Meriga Department of Biochemistry Sri Venkateswara University

Objective:To ensure the safety and evaluate the anti oxidant activity of terminalia paniculata(***)ethanolic extract in Sprague Dawley ***:The solvent extracts(hexane,ethyl acetate and ethanol)of *** were subjected to phytochemical analysis and their DPPH radical scavenging activity was *** oral acute toxicity was evaluated using ethanolic extract of ***:Ethyl acetate and elhanolic extracts showed more phytochemicals,whereas highest DPPH scavenging activity was found in ethanolic *** an acute toxicity study,*** ethanolic extract was orally administered(1000 mg/kg body weight)to rats and observed for72 h for any toxic symptoms and the dose was continued up to 14 *** the 15th day rats were sacrificed and blood samples were collected from control and test animals and analyzed for some biochemical *** did not observe any behavioral changes in test groups in comparison with their ***,there were no significant alterations in biochemical,hematological(hemoglobin content and blood cells count)and liver function parameters such as serum glutamate pyruvate transaminase,serum glutamate oxaloacetate transaminase,alkaline phosphatase,total proteins,albumin and bilirubin levels between *** ethanolic extract treated and normal control ***:Together our results demonstrated that *** ethanolic possessed potent antioxidant activity and it was safer and non toxic to rats even at higher doses and therefore could be well considered for further investigation for its medicinal and therapeutic efficacy.

关键词： terminalia paniculata Acute toxicity 2,2-Diphenyl-1-picrylhydrazyl Biochemical activity Hematological parameters

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Analysis of phytochemical profile of terminalia arjuna bark extract with antioxidative and antimicrobial properties

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Asian Pacific Journal of Tropical Biomedicine 2013年第12期3卷 960-966页

作者： Shreya Mandal Arpita Patra Animesh Samanta Suchismita Roy Arpita Mandal Tapasi Das Mahapatra Shrabani Pradhan Koushik Das Dilip Kumar Nandi Department of Nutrition Microbiology and Human PhysiologyRaja N L Khan Women's College

Objective:To investigate phytochemical screening,antimicrobial activity and qualitative thin layer chromatographic separation of flavonoid components,antioxidant activity and total flavonoid compound of terminalia ***:For phytochemical screening,some common and available standard tests were *** bioassay was done through agar well diffusion *** of antioxidant activity and flavonoid compounds were done through thin layer *** antioxidant activity was measured by 2,2-diphenyl-1-picrylhydrazyl(DPPH)in colorimetric *** chloride colorimetric method was used for total flavonoid ***:Phytochemical screening showed the active compounds presence in high concentration,such as phytosterol,lactones,flavonoids,phenolic compounds and tannins and *** anlimicrobial activity of extract showed that greater inhibition zone against Gram negative bacteria than Gram positive *** methanolic extract showed a promising antioxidant activity,as absorption of DPPH redicles decreased in DPPH free radical scavenging *** components having antioxidant property present in the methanol extract at a level of199.00 mg quercetin equivalent/g of dried methanol extract in colorimetric ***:The terminalia arjuna bark extract revealed the presence of bio-active constituents which are known to exhibit medicinal as well as physiological activities.

关键词： terminalia arjuna Phytocompound TLC Antioxidant Total flavonoid Antimicrobial activity DPPH

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Identification of Alternariaspp. as Pathogenic on the Native Species terminalia australisand Salvia guaranitica

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American Journal of Plant Sciences 2013年第6期4卷 36-41页

作者： Mariana Kameniecki Eduardo R. Wright Marta C. Rivera Plant Pathology School of Agronomy University of Buenos Aires Buenos Aires Argentina

This work is the result of activities included in the cooperative project between Asociación Ribera Norte (ARN) and the Department of Plant Pathology, School of Agronomy, University of Buenos Aires. ARN is a non-governmental organization created in 1993 mainly for the management of the Reserva Ecológica Municipal Ribera Norte, a preservation area located in San Isidro (North of Buenos Aires), within the Provincia Paranaense region. The aims were to identify diseases in native plant species growing there. Light brown leaf spots with thin brown margins and narrow yellow halos were observed on terminalia australis (mean disease severity: 25%). The pathogen was isolated, inoculated on healthy plants, reisolated from infected leaves and identified as Alternaria tenuissima. Similarly, another leaf-spot disease was observed on Salvia guaranitica, characterized by reddish brown large spots developed from the apexes and margins towards the centre of the leaves, reaching the veins in some cases (mean severity: 20%). Pathogen isolation, inoculation and reisolation led to the identification of A. alternata as the causal agent of the disease. Unusual heavy rain is analyzed as disease conductive.

关键词： Alternaria tenuissima terminalia australis A. alternata Salvia guaranitica Diagnosis

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Evaluation of Analgesic and Anti-Inflammatory Activities on Ethanolic Extract of terminalia chebulaFruits in Experimental Animal Models

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American Journal of Plant Sciences 2014年第1期5卷 63-69页

作者： Md. Safkath Ibne Jami Zakia Sultana Md. Ershad Ali Mst. Marium Begum Md. Mominul Haque Department of Chemistry and Biomolecular Sciences Macquarie University Sydney Australia Department of Chemistry Dhaka College National University Dhaka Bangladesh Department of Pharmacy University of Asia Pacific Dhaka Bangladesh Department of Pharmacy University of Rajshahi Rajshahi Bangladesh

The present study was undertaken to evaluate the analgesic and anti-inflammatory activities of ethanolic extract of terminalia chebula (commonly known as Haritaki) fruits in experimental animal models. The study was carried out using Swiss Albino mice (20-25 g) and Long Evans rats (100-150 g) of either sex. The analgesic activity of terminalia chebula was assessed by using hot plate method. For the determination of analgesic effect, doses of ethanolic extract of terminalia chebula used in the present study were 250 mg/kg and 500 mg/kg body weight (BW). Anti-inflammatory effect was analyzed by carrageenan induced paw edema method with the administration dose of 300 mg/kg BW of animals. The analysis of experimental data was performed by statistical process of ANOVA to determine the variability of sample, while Dunnet’s test was performed for evaluation of comparative analgesic and anti-inflammatory activity of terminalia chebula with control and standard. The animals were divided into four treatment groups of six animals each and the “Mean ± SEM” is the statistical identifiable value of the data and P values terminalia chebula fru

关键词： terminalia chebula Analgesic Anti-Inflammatory Hot Plate Carrageenan Induced Paw Edema

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