In vitro anti oxidant activity and acute oral toxicity of Terminalia paniculata bark ethanolic extract on Sprague Dawley rats

作     者：Ramgopal Mopuri Balaji Meriga 

作者机构：Department of BiochemistrySri Venkateswara University 

出 版 物：《Asian Pacific Journal of Tropical Biomedicine》 (亚太热带生物医学杂志（英文版）)

年 卷 期：2014年第4卷第4期

页      面：294-298页

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Supported by University Grants Commission(F.No.42-666/2013) Council of Scientific and Industrial Research(09/152(292)/2013,EMR-Ⅰ),New Delhi,India 

主　　题：Terminalia paniculata Acute toxicity 2,2-Diphenyl-1-picrylhydrazyl Biochemical activity Hematological parameters 

摘      要：Objective:To ensure the safety and evaluate the anti oxidant activity of Terminalia paniculata(***)ethanolic extract in Sprague Dawley ***:The solvent extracts(hexane,ethyl acetate and ethanol)of *** were subjected to phytochemical analysis and their DPPH radical scavenging activity was *** oral acute toxicity was evaluated using ethanolic extract of ***:Ethyl acetate and elhanolic extracts showed more phytochemicals,whereas highest DPPH scavenging activity was found in ethanolic *** an acute toxicity study,*** ethanolic extract was orally administered(1000 mg/kg body weight)to rats and observed for72 h for any toxic symptoms and the dose was continued up to 14 *** the 15th day rats were sacrificed and blood samples were collected from control and test animals and analyzed for some biochemical *** did not observe any behavioral changes in test groups in comparison with their ***,there were no significant alterations in biochemical,hematological(hemoglobin content and blood cells count)and liver function parameters such as serum glutamate pyruvate transaminase,serum glutamate oxaloacetate transaminase,alkaline phosphatase,total proteins,albumin and bilirubin levels between *** ethanolic extract treated and normal control ***:Together our results demonstrated that *** ethanolic possessed potent antioxidant activity and it was safer and non toxic to rats even at higher doses and therefore could be well considered for further investigation for its medicinal and therapeutic efficacy.